ID R7T2F3_DICSQ Unreviewed; 2747 AA.
AC R7T2F3;
DT 24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2013, sequence version 1.
DT 27-MAR-2024, entry version 59.
DE RecName: Full=Ras-GAP domain-containing protein {ECO:0000259|PROSITE:PS50018};
GN ORFNames=DICSQDRAFT_104612 {ECO:0000313|EMBL:EJF62265.1};
OS Dichomitus squalens (strain LYAD-421) (Western red white-rot fungus).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC Polyporales; Polyporaceae; Dichomitus.
OX NCBI_TaxID=732165 {ECO:0000313|EMBL:EJF62265.1, ECO:0000313|Proteomes:UP000053319};
RN [1] {ECO:0000313|EMBL:EJF62265.1, ECO:0000313|Proteomes:UP000053319}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LYAD-421 SS1 {ECO:0000313|EMBL:EJF62265.1,
RC ECO:0000313|Proteomes:UP000053319};
RX PubMed=22745431; DOI=10.1126/science.1221748;
RA Floudas D., Binder M., Riley R., Barry K., Blanchette R.A., Henrissat B.,
RA Martinez A.T., Otillar R., Spatafora J.W., Yadav J.S., Aerts A., Benoit I.,
RA Boyd A., Carlson A., Copeland A., Coutinho P.M., de Vries R.P.,
RA Ferreira P., Findley K., Foster B., Gaskell J., Glotzer D., Gorecki P.,
RA Heitman J., Hesse C., Hori C., Igarashi K., Jurgens J.A., Kallen N.,
RA Kersten P., Kohler A., Kuees U., Kumar T.K.A., Kuo A., LaButti K.,
RA Larrondo L.F., Lindquist E., Ling A., Lombard V., Lucas S., Lundell T.,
RA Martin R., McLaughlin D.J., Morgenstern I., Morin E., Murat C., Nagy L.G.,
RA Nolan M., Ohm R.A., Patyshakuliyeva A., Rokas A., Ruiz-Duenas F.J.,
RA Sabat G., Salamov A., Samejima M., Schmutz J., Slot J.C., St John F.,
RA Stenlid J., Sun H., Sun S., Syed K., Tsang A., Wiebenga A., Young D.,
RA Pisabarro A., Eastwood D.C., Martin F., Cullen D., Grigoriev I.V.,
RA Hibbett D.S.;
RT "The Paleozoic origin of enzymatic lignin decomposition reconstructed from
RT 31 fungal genomes.";
RL Science 336:1715-1719(2012).
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DR EMBL; JH719406; EJF62265.1; -; Genomic_DNA.
DR RefSeq; XP_007364977.1; XM_007364915.1.
DR GeneID; 18833534; -.
DR KEGG; dsq:DICSQDRAFT_104612; -.
DR HOGENOM; CLU_000249_0_2_1; -.
DR OMA; TKEPYMF; -.
DR OrthoDB; 1356198at2759; -.
DR Proteomes; UP000053319; Unassembled WGS sequence.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProt.
DR CDD; cd05392; RasGAP_Neurofibromin_like; 1.
DR Gene3D; 3.40.525.10; CRAL-TRIO lipid binding domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR001251; CRAL-TRIO_dom.
DR InterPro; IPR036865; CRAL-TRIO_dom_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR039360; Ras_GTPase.
DR InterPro; IPR023152; RasGAP_CS.
DR InterPro; IPR001936; RasGAP_dom.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR PANTHER; PTHR10194:SF142; NEUROFIBROMIN; 1.
DR PANTHER; PTHR10194; RAS GTPASE-ACTIVATING PROTEINS; 1.
DR Pfam; PF13716; CRAL_TRIO_2; 1.
DR Pfam; PF00616; RasGAP; 1.
DR SMART; SM00323; RasGAP; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR PROSITE; PS00509; RAS_GTPASE_ACTIV_1; 1.
DR PROSITE; PS50018; RAS_GTPASE_ACTIV_2; 1.
PE 4: Predicted;
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000053319}.
FT DOMAIN 1349..1541
FT /note="Ras-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50018"
FT REGION 1..32
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 148..194
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 9..32
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 156..194
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2747 AA; 305463 MW; E2B87BDE4704A053 CRC64;
MPARRASAGH NIASTSRVHR SNGSNHSISA QSPVLQSSNL PYSSNIPPSP QQKVVQVLIN
RLKNKLPCNS GISLTELEAD DAVQQTVEAL VDLSRDSLDM ISLALTEQLE RLAKQIEGAG
YRGVDILQSQ LFLLKVLALA MASRWGSRVE DTRPSSRTSK PAPGSKPTTP DSSIPTSDRG
RHPSSDQLST NTPTLVSVAT PTLVEPPALD DNCAKYIISV MVLLLRQASP RRNRLTSATN
LSFDASFQDM ESVESHEFGA NDEAPLNLPN IMSGVPRTMN RAKHPSLASL NSGGKTSSIS
SRLPQHSAAY ERTSFLVAKS VLSLHCAIAK YTGRIVYHLS ASNWSVVLGR IRQRIHGLAS
TADAEPDTVD LQLITYSALD RNKLVQSLQE LSSLLMNLKK DAQVPVSIAL RTAVWNWIEL
CDDEYNDALR YHRRLDGAPE RVFDLLYDLQ ESSRDKAGAW PTLAVLLCVS GDRMKAEYEA
NALVGQQRGA RKERNITDLI IKNLPFGSRY FDVALVCAVD ICRAASRVRP RADSENEVPL
ISMAYDIAHE LKIALLKWTK DKPFWECPDE IEVALVSDAL AALYRFLPEE ESLGIFQQCL
EPERSDAVKL CVMKACLTLV VDGWKLPWQR PLATLKNHVM KRMNTIFYAT YVRRSEVDAN
GSSRKPSMRP KAKRYTSEIL PDRELLILAI LTLWRANFEW YIDSQPDEII DNFFSLCVSV
YITPADPAIR WSLGRTFRCF MEYILSCPKD HPRWDLMSRW VSEAVPAVLA SVASHLLNTR
TDLQTQRMLI HFAYEFMYRY AERDPPSQYS ELRMMPTRIP AFALAEIAFL VCLSSADGIV
SLTACNCLRL LAQAERQPDA PQPLELSEDE VLKRHPVYEQ LGDPKVSMIG RVGHQKRIRK
LMRLLTSPSA IHVAVWQELY FRWCALTEMT VRQTFEQASD GLDNGPAPVG DKTLPMEERQ
AQWQNLTLLL ASLGAACTRD HHDPSALAKV IPASIIPDSC RVLRDPSDLL TNFLTETVNL
LVNDLPQVRD VAREALSNEA SHRLYGKIVK QLDDVIRQVT DDENVNYPVL VVFLDQFIAI
LKVLSDNVNS LAEDLRVADI PSLLYTVATF ISRIDGADPT SARLKLKFCV LCNSVFSRTE
PVMMRNKESS MRQSIIDIII DWVQETTLEE AQASTVQHEL NVAVFNTTVT LFDRLQLEPS
DGATGEDAAH AVSRLFIRYA SFLIKTWESV RYDGNSKDDG ISEKSSFSKI RIQQREGEYR
EQLINGLSSL VSANTECGVK HCLTLAYEPD STKRLIFTHV FIRVLKEGIK FMPYEETPVI
VKQSPLCELV KGPDMALALA ICEICPPNEV DAMNAVLLNL FDTRSTLMNL LKTMIDLEIG
KTESDTALFR GNSTCTRFLS AFARVYGYNY LRSLIVPLVK LVTTMPPGHG YELDPARVSR
EELKQNKDTV EFITGKFLEI ISSSIPALPS IIREICAHIA KAVNEVWPEA KFAALGAFIF
LRFISPAIVT PETVDVAIPN NDPTIRRGLM VIAKIIQNLA NNILFGKEAH MVILNDFLKD
NIVTVTKFLS EINKHVPPGS EEEADEWLER TYDDTDTIIL HRFFERHADK IGKELLSSSK
VLAEKMTPEA EAAAANGKRA WDALCAALVE LGQPLESPKL STLTSREHRD YLDLMSRCDR
RDTTAVQELF VEGITPQSSN AVFVLSVSKI NIEVLDLELL LYYIFKCITS STNDNRDFDV
ILDFTAFSST SQVPAQWLKF ATETIPVDIW RRFQTLRLLT PNGFALRYLR RLYNNLTSGA
TESLHIAIHT SVGELLSQYP DGLTAASLGY AVGLEAEISD EFQDVTMRHT HPMRVPVSMR
VAQSHIRIIT TKALTISNSL SSKATEIIPL SDINDVYNVS TGHDSHEFII RKVRQGVTMY
FSSPYRDAIV KAIRAAKGLM LTAHLPSADR HDRLSNVITT LLRIALVGIS TDDETRTASF
ELLSAICTYL DFEGRPAVPS KGVVATGHPG PFLVMVSEGL SNHVPQLTMD FLSEMAGNIA
KMDVPLRANC LQYLCPWIKN LALFTDPCSK FYEPSGTRFR DCIRMLVDLT TGETELHSFV
QKFIWFEVGK LETNTINIIL DELMRAAVDG GMGSSRCEKV ADTMSALNTI NVRGRVLARV
RKVIGKTSIK PTRNLSENVH WNEIACLTRL ILVIGNSAKN TVQSQLFVPE IMHLVTLIAA
TGELYVRSTV YAIITHMLHA MCSLRLTDAT ASPEIEALLD ECCQPEGLRL FGLSRPTPTS
EYVIYDPPNG KALIDDLEAL TKLLVRIMQA ISGTKGLLNV WRARWMSLIT SSAFQLSPAV
QSRAFVALGV LAKSDVDDDL LYQMLVAFKT ALSQASETDT TSVVSMLRCI TNVVPATNGN
SRYLAQLFWL AVALLQSSHM ALYVEAIRLL RVTVENMAEH GHFKERGVPA TLLEGRVALE
DIACQLDHLL GLSFDSSFSF SLAATVFKGV RHSALRDAAE GALRSLLNIT VRSCVEVEHA
DDGPGAPICH DVLGYVLALI PMSTRVRSFK RLLEEANVDQ SWLSEDAVWS TDEEDSVYRM
PFGLIGYADS NTALLVTSFV TAMLATAQGD DTESAILYNI LSDVADAWPE VIGVAYESLQ
DKIKETFANS NSPVILLAVS NVFRVATQDM ERTAPPSSRT LAGAGSASTL STVDEGVVHG
PGRRHLNALE EQGMQGLVNS FQFLPLNRGH ATKMIQWISE LVMKMIE
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