ID R7TFZ0_CAPTE Unreviewed; 1088 AA.
AC R7TFZ0;
DT 24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2013, sequence version 1.
DT 27-MAR-2024, entry version 50.
DE RecName: Full=HECT-type E3 ubiquitin transferase {ECO:0000256|ARBA:ARBA00012485};
DE EC=2.3.2.26 {ECO:0000256|ARBA:ARBA00012485};
GN ORFNames=CAPTEDRAFT_228035 {ECO:0000313|EMBL:ELT92644.1};
OS Capitella teleta (Polychaete worm).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Annelida; Polychaeta;
OC Sedentaria; Scolecida; Capitellidae; Capitella.
OX NCBI_TaxID=283909 {ECO:0000313|EMBL:ELT92644.1};
RN [1] {ECO:0000313|Proteomes:UP000014760}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=I ESC-2004 {ECO:0000313|Proteomes:UP000014760};
RA Hellsten U., Grimwood J., Chapman J.A., Shapiro H., Aerts A., Otillar R.P.,
RA Terry A.Y., Boore J.L., Simakov O., Marletaz F., Cho S.-J.,
RA Edsinger-Gonzales E., Havlak P., Kuo D.-H., Larsson T., Lv J., Arendt D.,
RA Savage R., Osoegawa K., de Jong P., Lindberg D.R., Seaver E.C.,
RA Weisblat D.A., Putnam N.H., Grigoriev I.V., Rokhsar D.S.;
RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ELT92644.1, ECO:0000313|Proteomes:UP000014760}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=I ESC-2004 {ECO:0000313|EMBL:ELT92644.1,
RC ECO:0000313|Proteomes:UP000014760};
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
RN [3] {ECO:0000313|EnsemblMetazoa:CapteP228035}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JUN-2015) to UniProtKB.
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DR EMBL; AMQN01013239; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KB310056; ELT92644.1; -; Genomic_DNA.
DR AlphaFoldDB; R7TFZ0; -.
DR STRING; 283909.R7TFZ0; -.
DR EnsemblMetazoa; CapteT228035; CapteP228035; CapteG228035.
DR HOGENOM; CLU_002173_2_1_1; -.
DR OMA; MRVQGHL; -.
DR Proteomes; UP000014760; Unassembled WGS sequence.
DR GO; GO:0061630; F:ubiquitin protein ligase activity; IEA:InterPro.
DR GO; GO:0000209; P:protein polyubiquitination; IEA:InterPro.
DR CDD; cd00078; HECTc; 1.
DR Gene3D; 3.30.2160.10; Hect, E3 ligase catalytic domain; 1.
DR Gene3D; 3.30.2410.10; Hect, E3 ligase catalytic domain; 1.
DR Gene3D; 3.90.1750.10; Hect, E3 ligase catalytic domains; 1.
DR InterPro; IPR044611; E3A/B/C-like.
DR InterPro; IPR000569; HECT_dom.
DR InterPro; IPR035983; Hect_E3_ubiquitin_ligase.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR PANTHER; PTHR45700; UBIQUITIN-PROTEIN LIGASE E3C; 1.
DR PANTHER; PTHR45700:SF2; UBIQUITIN-PROTEIN LIGASE E3C; 1.
DR Pfam; PF00632; HECT; 1.
DR SMART; SM00119; HECTc; 1.
DR SUPFAM; SSF56204; Hect, E3 ligase catalytic domain; 1.
DR PROSITE; PS50237; HECT; 1.
DR PROSITE; PS50096; IQ; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000014760};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786,
KW ECO:0000256|PROSITE-ProRule:PRU00104}.
FT DOMAIN 750..1088
FT /note="HECT"
FT /evidence="ECO:0000259|PROSITE:PS50237"
FT REGION 1..30
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 352..372
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 1056
FT /note="Glycyl thioester intermediate"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00104"
SQ SEQUENCE 1088 AA; 124107 MW; 1E9119469964ABDC CRC64;
MYSFEGDFRK KPTQSLGGAS RKEERGSLIQ RTQEERRKRE LLRKQQLSAL IIQSFYRGYR
NRVSAQNAER DGFDITWSQH RKQRQATEID AVGIASLIRK IVFFYKDGQD DDRLLWLCQL
LIRQQKNIIE WMTGTEIVTM LQMKRLLVLC LRHLRHVAFT NTQIAFPLRM LEVFLNRQAY
PVDKQENVFS VLVHHLVQNG FYSTLRSLVE ARVPCGMGSS VNPPTPLAAS LLALIRLPLS
IVSTQSNSPV MRLLCTQLFC RPFSEQMQEF LMPALAYGSQ PFPFVDLLHT LLPLCQRSDD
SQVKAESFEP SVWLLYAVLT LADQHLGKVN EHHLEMYLRL LQSLIPSLQE AKKKNRRRPI
SPDEESSSEE EIEFDPHFQA GALSFAYQEC LNLLDREKHV IAVVAAVRPG ASAEAVTAVC
SLCHALMSQH QLSIHKTRLL YSLAFNPGFV RQLWHTCISI TTTTVTGSKT SLLQMLCRGL
DMPWTDKDQI VPLLSVFCSL FSHSLTSLHD SEFYGNENCK SNEALYPLAN LFYSASKSFM
PFHLNELVPM TRVLCDVCLG VVELAHPEAK PTLSNNYRAA FWSVGAARNS LEPDELLARR
DLWAYLFKVS AQLVKQLYGR DSRRTFCPQG HWLASQLNIY ADSPSQLYQN PHPVFIRRPF
GTLSALNPDR MLEEEGPPLS TTEVRKLTIL TELPFVVPFA ERVKIFHKLV SQDKSEHQGV
SIFAGGPHID IQVRRTFLYE DAFERLNPDN EPNMKLPMRV QLKNFAGLDE AGIDGGGIFR
EFMAELLKTA FDPNRGFFKC TTDKLLYPNP QAGLLVEAYT QHYYFLGRIL GKAMYENMLV
ELPFASFFLS KILSTSRGDV DIHHLASLDP QMYKNLLFLK TYDGDVSSLD LDFTVINDIL
GETEIEDLKA GGRDIPVTNH NRIEYIHLMA DYRLNKQIRS HCAAFRQGLT DVISLDWLRM
FDHNELQVLI SGAEIAIDLE DLKKHVNYSG GYTAEHQVIQ WFWQAIESFT DSQKRQLLKF
VTSCSRPPLL GFKDLYPAFC VHYAGKENRL PTASTCMNLL KLPEFPNLVT LTQKLIYAIE
SGSGFELS
//
