ID R7TSZ2_CAPTE Unreviewed; 3794 AA.
AC R7TSZ2;
DT 24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2013, sequence version 1.
DT 27-MAR-2024, entry version 57.
DE RecName: Full=Calponin-homology (CH) domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=CAPTEDRAFT_160045 {ECO:0000313|EMBL:ELT94606.1};
OS Capitella teleta (Polychaete worm).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Annelida; Polychaeta;
OC Sedentaria; Scolecida; Capitellidae; Capitella.
OX NCBI_TaxID=283909 {ECO:0000313|EMBL:ELT94606.1};
RN [1] {ECO:0000313|Proteomes:UP000014760}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=I ESC-2004 {ECO:0000313|Proteomes:UP000014760};
RA Hellsten U., Grimwood J., Chapman J.A., Shapiro H., Aerts A., Otillar R.P.,
RA Terry A.Y., Boore J.L., Simakov O., Marletaz F., Cho S.-J.,
RA Edsinger-Gonzales E., Havlak P., Kuo D.-H., Larsson T., Lv J., Arendt D.,
RA Savage R., Osoegawa K., de Jong P., Lindberg D.R., Seaver E.C.,
RA Weisblat D.A., Putnam N.H., Grigoriev I.V., Rokhsar D.S.;
RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ELT94606.1, ECO:0000313|Proteomes:UP000014760}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=I ESC-2004 {ECO:0000313|EMBL:ELT94606.1,
RC ECO:0000313|Proteomes:UP000014760};
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
RN [3] {ECO:0000313|EnsemblMetazoa:CapteP160045}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JUN-2015) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}.
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DR EMBL; AMQN01002497; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMQN01002498; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KB309374; ELT94606.1; -; Genomic_DNA.
DR STRING; 283909.R7TSZ2; -.
DR EnsemblMetazoa; CapteT160045; CapteP160045; CapteG160045.
DR HOGENOM; CLU_000246_3_0_1; -.
DR OMA; DWCSTLM; -.
DR Proteomes; UP000014760; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0048856; P:anatomical structure development; IEA:UniProt.
DR CDD; cd21187; CH_DMD-like_rpt2; 1.
DR CDD; cd16242; EFh_DMD_like; 1.
DR CDD; cd00176; SPEC; 9.
DR CDD; cd00201; WW; 1.
DR CDD; cd02334; ZZ_dystrophin; 1.
DR Gene3D; 1.20.58.60; -; 15.
DR Gene3D; 2.20.70.10; -; 1.
DR Gene3D; 3.30.60.90; -; 1.
DR Gene3D; 1.10.418.10; Calponin-like domain; 2.
DR Gene3D; 1.10.238.10; EF-hand; 2.
DR InterPro; IPR001589; Actinin_actin-bd_CS.
DR InterPro; IPR001715; CH_dom.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR035436; Dystrophin/utrophin.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR015153; EF-hand_dom_typ1.
DR InterPro; IPR015154; EF-hand_dom_typ2.
DR InterPro; IPR018159; Spectrin/alpha-actinin.
DR InterPro; IPR002017; Spectrin_repeat.
DR InterPro; IPR001202; WW_dom.
DR InterPro; IPR036020; WW_dom_sf.
DR InterPro; IPR000433; Znf_ZZ.
DR InterPro; IPR043145; Znf_ZZ_sf.
DR PANTHER; PTHR12268:SF14; DYSTROPHIN-1; 1.
DR PANTHER; PTHR12268; E3 UBIQUITIN-PROTEIN LIGASE KCMF1; 1.
DR Pfam; PF00307; CH; 2.
DR Pfam; PF09068; EF-hand_2; 1.
DR Pfam; PF09069; EF-hand_3; 1.
DR Pfam; PF00435; Spectrin; 8.
DR Pfam; PF00569; ZZ; 1.
DR PIRSF; PIRSF002341; Dystrophin/utrophin; 3.
DR SMART; SM00033; CH; 1.
DR SMART; SM00150; SPEC; 17.
DR SMART; SM00291; ZnF_ZZ; 1.
DR SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR SUPFAM; SSF47473; EF-hand; 2.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR SUPFAM; SSF46966; Spectrin repeat; 18.
DR SUPFAM; SSF51045; WW domain; 1.
DR PROSITE; PS00020; ACTININ_2; 1.
DR PROSITE; PS50021; CH; 2.
DR PROSITE; PS50020; WW_DOMAIN_2; 1.
DR PROSITE; PS01357; ZF_ZZ_1; 1.
DR PROSITE; PS50135; ZF_ZZ_2; 1.
PE 4: Predicted;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203};
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00023212};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000014760};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00228}.
FT DOMAIN 1..52
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 67..172
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 3064..3097
FT /note="WW"
FT /evidence="ECO:0000259|PROSITE:PS50020"
FT DOMAIN 3318..3374
FT /note="ZZ-type"
FT /evidence="ECO:0000259|PROSITE:PS50135"
FT REGION 178..210
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1912..1939
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3644..3687
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3775..3794
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 362..389
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 969..1003
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1170..1254
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1289..1342
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1531..1569
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2020..2084
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2619..2646
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2944..2971
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3023..3050
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3491..3525
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3576..3606
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 190..210
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3777..3794
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3794 AA; 433023 MW; 1B1961EC87FC6A56 CRC64;
MRVHHMNNVN RVLQILETDY NIKLVNISGN DVVEGNTKIT LGLIWSIIQH WQVKDVMKEV
MTELRQTNLE KTLLAWCRNT TEGYPNVNIK NFTDSWRDGL AFNALMHKYH PEYFDFDSLL
SEDINSRLQH AFRVAYDKLS IEKLLDPEDV NVDHPDKKSI VMYVTCFFQV LPHSHIVMDS
DPDTPSEEAS LPPPSKSTSA STSSSLSQLG SPEACADLGA FNQSLEMVMT WLLQAEETLA
QQNDVGSDVH TVKEQFHQHE EFMLQLTQHQ GSVGSVLQEG SSLLREQNIN SDDEKAIQNQ
MSLLNNRWEG LRVTAMERQS KLQQELMEQQ QAQLNKLGSW LTEMEQKMKE CGGFVAGDVD
VVTEQIRKQK ALQSQVEEQQ DRVNSLQNMV VVVDDTNSES ACMALEEQLE ALGQRWASVC
KWTEEHWLLL QEMLTRWQHY NDECRLFSDW LMEKESVLAA MRLVDISELK EVVDQVRQLK
QDMDLQVQTF DDLNDRGQEL VSFLNNDPET VQKINAQLQE FQERWDNLVQ QMEYQSKEIS
HSGIDLQVTK GQNGSYTITV TRREGSTVIT ETITTSSSTL TSSNVGYLSA PKRPRIESKH
RHEFESEIAS LSEWFDKTEV NIELLTMEPS DPQDQLTLEE QMVLDTERDI LSRQPHMDKF
HSVANSFKLE LSNAGEPTEL IEEAVEQVDQ RWQGLNDLLK LTKSKVMLNH ETKQFYEELT
SLRGILMTYE RWIGTAEGMS DEALEITKQL EQCRVKLKAM KSHEGQAEKL GKLVEDLAGR
DVDATDTLQS IQQDLLDFTT RWQNTFTKIG ERQQQLTKAL EKAPPKSYLD AMAALLKWIE
GVELLLQSEP FLVTESDIMQ EQLVQYRALQ GDIQDHLGNL EYINHTGKDL LTRAASGDKT
EKLNSNLKSL NERWTEVSNS IDTRVDKLED AIAQLKQYQT QTGGLERWMA EMDVYLRTDE
VATGDLEMVQ AQIQENEGVK EDIRTLQENL DNVNEIIADL VEIADNDFTE RLTKEVDELN
SQWESVKVLS KEQSDRLTRG MEMTEKVHNQ IKVLEKYMDS VNREHLAHEY TVHTKEELVQ
LNTKFKKRSQ ELEQLVKDVN SIVGDGSPGN LEPLVNSKAK VEQRWLQIRK DAEDLNMKFQ
TCVNNLTKFK ILLSEEFRWL DTMDKRLSER PKACVDAEEI SEELDELENQ LHNHSKQQKS
QIESTAQSLI NNHIMVAKVQ TDLEEFQTRF ESTEAKAKQR QEDLEEAIQQ AQLRESQIIE
MTNWMDDVSG LLQSRLDADI LAGESPSEFE GLKAEFEEQE VLLKQLEQQA EEFSSEGKTE
AAERLEQQVT ILKQHFAELE LKFCKFQRPV DFEPKLNHAK RTLSDIGERI HLIEVSSDDM
EVLQPQMETC LKFYRTMTEL KSDVEYVIKT GRQVVEKKQV DFPDKLNAQL DALKQQYNDL
GGQVTNGKQK LEKSVKVAKK LRRESHLLRD FLTLTDEELS NRESVRMPKD MEAEIKWIKA
TQADLQKRQS SATNVVDLVT QLSSLAEEGT LVDAEQSMRQ LADQYQDLVD RLAARKHNLK
EECVAQESRY IEFTTSVQEM SVWMDHVEDT LNQSEQLSHE DQVAEAEIEK FKVINSTDME
MNFFLLGYQI RYWPIAPLRK NCHSVSPRLV HPTAASAVCP QHATAEEAAF KAIADTSWRA
VSALHSLICR VCLRTMPPFI ERKSLSISTT PNPSYVDHNG SVMFGIYSSL FISFEIRMKL
PLPMATNRPS HCLLSPACYG IAEFFHWSHF QTVQFEQSDF KATVDNVRDT AVDLMSRSEK
YAKLVEPELS SLNQRWSDIS KRLQVGAQRV DYAMCYVIHV EGETEPAPRN KLRERVQGLL
LEGEKQADDL QAKNPEEAQK IQEHAARLKT KWESVQENRE SKVVVASVTF ARSRREEDSG
QSTEERKREE AEGDAEELKA FEDEVAEHED EMGNRMQEGD EMDGVEERCT QLTTTNSNSA
VEASSVDEDE VVAMETSVTE MSISMTSSVC IVSTSPTEFI QGLERLLVVL EDILSELQCS
LLHGRQYEDF SSQEDKLKSI REALDNVQSS LQTAEQRQQE ALTNANSDEN LRIAELMASV
RQQWTVANTQ YNDRHSRWNC SVEMWGRFHC NLKDLASWLT DAEAKLQDSK NANGQLDVQV
AKDYQKELEE AIKIHQSTVA SLNASGGEII DQSSAPDSSL LTEKLDSLNQ RWRLVCTEVS
DRKERFEENS LSAQQLKEDL DDLTSWLRET DNIITSKLRP ADEEYLEDLL EKVKDREEEI
SLQQNAIDTL IAAQVEDDLS VVQEQWVRVQ HGLPAKRAAA EQALSNIRMF SGDLEALSAW
MTSSKEILEH KNSAGASSST AQGENDSIVV DPANMQEALS ARQKNMNNLT DRFEGLCKEC
SMLGVPVPEH LQAKVDQLHA DWELVHELAS QLRPLSDTSM EESVFIEGIV LVASITRVTT
QTVQTAVAMA TSPTTPESSS SDLESALATR HNALRAVMTS LNLRRAIVGR SEHVESRLKE
VQEHDLGTGS SHPTLKRLVP YSSIMYTCTF PCISFSVERL REQWDEAGAK AAQRRRLLDE
MLQDSRHLEE LRSDIERFLG QWAAECDRRP EATASVDRVE QQLQSHKKLQ EEVESFQSKV
DDFNDHADRM AEVYSQDDLS SLKDTVSQVN AGWTSLLARL STRQKSLQNS LNTVHRFQSD
LRELTLWSTK VEGSAPSILL IDETKSDFAN RRRVVICLFD LQAEIDAHQH VYESVSGTGA
QIVHSMQQQQ DIAGQAEDAV SLQKCLEDMN HRWTRLKAKS VEIRGRLEAN AEQWNQLLET
LENLTRWTTE RETEIERQQP VGGDVHSIRQ QHLDHQAIRT QLEEKRASVE QSLETGRLYL
REEGLEDKRL KSEGSGSEKS PEQEARSIIK KIRRYVRLLN RKWVELNQRS NEWQHCIDET
LEKMEVFHTT LAEMTEDLTE AERERSKWLR VGDVVLDNLK KEIQSTNAFQ QNRVLPLRAQ
CDQLNDMANQ FHEMRVVLSH KNVSRLEDLS NRLKTLLASV EDRMQHLQEA LRDFGPNSQH
LLSASIEHPF ERAVAVNKVP YFINHDTETT HWDHPEMTKL MAGIADLNEV RFSAYRTAMK
LRTVQKKLCL DLLSMTSATE AFERHQLNSG GDKTMDVMQI INCTLEMYEA LAEMHPTLVN
VPLCVDLVLN WLLNVYDSIR NGHIRVLSFK ICIILMCKAH LEDKYRYLFT ELADAKGGMD
QRQLGLLLHD CLQLPRQMGE IASFGGSNIE PSVRSCFAKA HKEESLEVHE LLDWLKMEPQ
SMVWVPVLHR LAAAETAKHQ AKCNICKEFP IVGFRYRCLR CFNFDMCQNC FFSGRKAKGH
KLTHPMQEYC TATTSGEDVR DFTKMFKNKF RSKRYFKKHP RMGYLPVDSV HEGDPIECPA
APQSSPQHNS STLEMHSRLE LYANRLAEVE QRQCSATPDS DDEHQLIAQY CMSLQGDTPS
HQVSSPLQIM MGIDMDQRAE LEAMINDLEE ENLHLQKEYG RLKQVQLHQL EEEDGHFDEI
AQVASSVLPQ QQNGDADVAG GDAEMLAEAK LLRQHKGRLE ARMQILEDHN RQLEAQLQRL
RQLLDQPDSG PRIVTMVSSS ATTPGMSAAS SQSSLPYPGM HVSSYQSSTA GSGSYINGHS
ELRASSAEGP PSSMSTSAPA YPGCSQHPVH QSLQQKARHL QQITVRHEPL RDPDDDDYRE
GGTATDEELE EVMREIEHSF PPEPAVSKGS SANVGDLFRM AGQVGTAVST LVTVMTDEEL
SDEEEDEVDE DERK
//
