ID R7U3E8_CAPTE Unreviewed; 1104 AA.
AC R7U3E8;
DT 24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2013, sequence version 1.
DT 13-SEP-2023, entry version 52.
DE RecName: Full=SLIT-ROBO Rho GTPase-activating protein 1 {ECO:0008006|Google:ProtNLM};
GN ORFNames=CAPTEDRAFT_225880 {ECO:0000313|EMBL:ELU00651.1};
OS Capitella teleta (Polychaete worm).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Annelida; Polychaeta;
OC Sedentaria; Scolecida; Capitellidae; Capitella.
OX NCBI_TaxID=283909 {ECO:0000313|EMBL:ELU00651.1};
RN [1] {ECO:0000313|Proteomes:UP000014760}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=I ESC-2004 {ECO:0000313|Proteomes:UP000014760};
RA Hellsten U., Grimwood J., Chapman J.A., Shapiro H., Aerts A., Otillar R.P.,
RA Terry A.Y., Boore J.L., Simakov O., Marletaz F., Cho S.-J.,
RA Edsinger-Gonzales E., Havlak P., Kuo D.-H., Larsson T., Lv J., Arendt D.,
RA Savage R., Osoegawa K., de Jong P., Lindberg D.R., Seaver E.C.,
RA Weisblat D.A., Putnam N.H., Grigoriev I.V., Rokhsar D.S.;
RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ELU00651.1, ECO:0000313|Proteomes:UP000014760}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=I ESC-2004 {ECO:0000313|EMBL:ELU00651.1,
RC ECO:0000313|Proteomes:UP000014760};
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
RN [3] {ECO:0000313|EnsemblMetazoa:CapteP225880}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JUN-2015) to UniProtKB.
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DR EMBL; AMQN01009619; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KB305800; ELU00651.1; -; Genomic_DNA.
DR AlphaFoldDB; R7U3E8; -.
DR STRING; 283909.R7U3E8; -.
DR EnsemblMetazoa; CapteT225880; CapteP225880; CapteG225880.
DR HOGENOM; CLU_005715_2_1_1; -.
DR OMA; HQETEGF; -.
DR Proteomes; UP000014760; Unassembled WGS sequence.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd07656; F-BAR_srGAP; 1.
DR Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR031160; F_BAR.
DR InterPro; IPR001060; FCH_dom.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR14166:SF17; RHO-GAP DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR14166; SLIT-ROBO RHO GTPASE ACTIVATING PROTEIN; 1.
DR Pfam; PF00611; FCH; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR Pfam; PF00018; SH3_1; 1.
DR PRINTS; PR00452; SH3DOMAIN.
DR SMART; SM00055; FCH; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF103657; BAR/IMD domain-like; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS51741; F_BAR; 1.
DR PROSITE; PS50238; RHOGAP; 1.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|PROSITE-ProRule:PRU01077};
KW Reference proteome {ECO:0000313|Proteomes:UP000014760};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 25..308
FT /note="F-BAR"
FT /evidence="ECO:0000259|PROSITE:PS51741"
FT DOMAIN 490..686
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT DOMAIN 728..787
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 453..475
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 705..739
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 787..877
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 907..962
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 974..1104
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 707..733
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 787..805
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 807..824
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 832..857
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1019..1033
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1070..1084
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1104 AA; 123548 MW; 9C2EB0959C155B14 CRC64;
MRAWCQTVAI DNVSPADMRL ILKWREIRGQ LTEQLKHLDV RLETHFSMLL ELQEFYRRRA
EVELEYSVKL DKLVKNVITR HKQEKQSAQL RREFWPGYST YTCWQTLLAS TKRVSKDHAI
AGELYSGQMC NRLADLGEDL QRMYRNCRDI GILTHDELVK VLNELQNAMK TYHVYHGESK
QAESKLRYAE NQKSKVEQHA SRGTISKKFR NFEKQTEKRQ AKYDENKKKA LKSRNEYLLC
LDAANAAVHK YFVDDVPDLI DTIDYGYHNT LGRAMMMHLS AEENMIRSRQ GCCDLLSKSI
SDLDQRSDKQ RFLELHNLSF SLPKKFEFQA HKGDEVCQIS AQKSVQDEML DRLQALNDRL
NSIKVENEEI WKSLETADKS LMEMINQKDY DVTTLFQEEK QPPKSPHVYG KKRSDRLETE
AYYVTKFQGF LISNNLIARL QAKHKSLQKA LGEGDGSLLG SRPPSLPPKP KKRRALGKAR
LVGQPKLFGG SIEEYVEATG QEIPNIVRSC IRIINLYGMH HQGVFRVSGS QHEINDFKNM
FEKGDDPLSD VLDGKDINSI AGVLKLYFRE LREPLFPTQL FDALIACSSK SSPDLSEIEA
TQECIERVKE LLLPLPRPIL VVMRYIFAFL SHLSEYSDEN MMDPYNLAIC FGPTLLPIPD
SRDQVLYQNN VNDLTKTIIT HQEEIFPNDG GVVYEKCIVE EEAGSDDVLN NLSDDEDETG
DAASEEEPEV NEAEAQYDFQ GRTERELSFK KGDIIVVFNQ VSVDWWEGAY KGKEGLIPDK
YISVRRRDRD SSTEKGIEDV RRSTESLPAK YSGSSSSASD ECLDKAASQP NIAMATDPST
SSSSSSSLRT TSSELALGSG DEVDGEKGAS ADDPLGGFKI EKTTEDLAHD IDSALAEVMS
GLELLELQHT DERQPPPIHT KTLPTPKVKS HDPKHTPDLV LDLPITASPE SGDESSPPLS
TAEVFASNQS TIKKGAASSR VGGMGGAGGF SSGAPVPVLP AGAGKEILLG AKRRGQSASL
KVTKPTQPPE SSPVAKARTL PIGTKPGFEK DEDRPQSAGA GKHVSPKPPL KKKALPPPLK
AKPPIMRKPA RSPEVLKKLK EAKE
//
