ID R7U4Z2_CAPTE Unreviewed; 935 AA.
AC R7U4Z2;
DT 24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2013, sequence version 1.
DT 27-MAR-2024, entry version 41.
DE RecName: Full=CARD domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=CAPTEDRAFT_204372 {ECO:0000313|EMBL:ELT98761.1};
OS Capitella teleta (Polychaete worm).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Annelida; Polychaeta;
OC Sedentaria; Scolecida; Capitellidae; Capitella.
OX NCBI_TaxID=283909 {ECO:0000313|EMBL:ELT98761.1};
RN [1] {ECO:0000313|Proteomes:UP000014760}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=I ESC-2004 {ECO:0000313|Proteomes:UP000014760};
RA Hellsten U., Grimwood J., Chapman J.A., Shapiro H., Aerts A., Otillar R.P.,
RA Terry A.Y., Boore J.L., Simakov O., Marletaz F., Cho S.-J.,
RA Edsinger-Gonzales E., Havlak P., Kuo D.-H., Larsson T., Lv J., Arendt D.,
RA Savage R., Osoegawa K., de Jong P., Lindberg D.R., Seaver E.C.,
RA Weisblat D.A., Putnam N.H., Grigoriev I.V., Rokhsar D.S.;
RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ELT98761.1, ECO:0000313|Proteomes:UP000014760}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=I ESC-2004 {ECO:0000313|EMBL:ELT98761.1,
RC ECO:0000313|Proteomes:UP000014760};
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
RN [3] {ECO:0000313|EnsemblMetazoa:CapteP204372}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JUN-2015) to UniProtKB.
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DR EMBL; AMQN01010329; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KB307555; ELT98761.1; -; Genomic_DNA.
DR AlphaFoldDB; R7U4Z2; -.
DR STRING; 283909.R7U4Z2; -.
DR EnsemblMetazoa; CapteT204372; CapteP204372; CapteG204372.
DR HOGENOM; CLU_009460_2_1_1; -.
DR Proteomes; UP000014760; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR GO; GO:0042981; P:regulation of apoptotic process; IEA:InterPro.
DR CDD; cd01671; CARD; 1.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR001315; CARD.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR007111; NACHT_NTPase.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR46844; SLR5058 PROTEIN; 1.
DR PANTHER; PTHR46844:SF1; SLR5058 PROTEIN; 1.
DR Pfam; PF00619; CARD; 1.
DR Pfam; PF05729; NACHT; 1.
DR SMART; SM00114; CARD; 1.
DR SUPFAM; SSF47986; DEATH domain; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF52047; RNI-like; 1.
DR PROSITE; PS50209; CARD; 1.
DR PROSITE; PS50837; NACHT; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Immunity {ECO:0000256|ARBA:ARBA00022859};
KW Innate immunity {ECO:0000256|ARBA:ARBA00022588};
KW Reference proteome {ECO:0000313|Proteomes:UP000014760};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 1..95
FT /note="CARD"
FT /evidence="ECO:0000259|PROSITE:PS50209"
FT DOMAIN 176..300
FT /note="NACHT"
FT /evidence="ECO:0000259|PROSITE:PS50837"
SQ SEQUENCE 935 AA; 107909 MW; 115E85E94A1DEAE9 CRC64;
MEDRHKECLK SNRDFLCSNI SLSTGLLAKL SESGVITDEH LQKLQNIKRN DTTKAAVLEF
LTEVLPRRAP EAFNLFLEAL SKSAQKHIAD HLKKWLGDVC SEDAGTFERL RAELRSHYKR
RLASIRPMPW QQDIYLNLTD VFVERQLKLK TNYKGDERIV SMDDLFTPQQ TKEIPRRLLI
EGNPGIGKST ICQTLAHEWG KQSCGRHCGT LCVHSFDLVL YFHAGDFIDE ESVAHAVQKH
LLPSDCRITT SELQGVIEAK NVLIIVDAFD EANAGNRTLD RLIKGDIIRH KTLLITSRPN
FLQNKLSLFD SKFKVEGYDK EEQLKHVERY AAHQNIASAP FESMLKEESI IDLCSNPLNL
TLLCLLREED TQLRITRTAL YTSIHRIIKQ KAAKRLNLAP EKVEESLLRP LYRFAFEAHQ
KNETVVGEND FKKVKNFQQV CEVGYLTREL SMSRLQPEVR FQFTHKTFLE FLTAKHIAEM
DREERLNWLQ HLRYADYHIR IEGLAIDDDF KVEQNEPILA FLFGLLEEES AELTEMASLV
IKETHFSSEP LPMPLHSSLF PISLDSPCNA SHQLLRLLAE LNVVPPELAD VICKRRPPLI
KFHRHCSASC MKGMLKLCNL RFQPPIPMNV HLGDSRDEEK MSFVQKLIKC KSIESSKIWI
DPRDHTKLRN DVRGLQIGQT NSFQQVRIDC YFIKGNRLFA ALLRKIKRRR VSFGNHLSEL
ELIGFKPSRS FLLEAALHKP LTSLQLIHCF ELDDRCISLI HQLLRNQRNL QRVQLTSFWQ
QQHFGFFLAD FAQMENLQSL EISLKNSTDE EKRSLEAILK RNKLSELTIH SDYSRSLYSV
LNDGFNSMSS LRELRLQRVN IIHLPNLCHL DLINFSLLPY STLNDDGIAV LSDVLRSWRN
LQQLSIDFDE YVSVAECSLR KLFEAIAGCH LNATD
//
