ID R7U7S4_CAPTE Unreviewed; 2112 AA.
AC R7U7S4;
DT 24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2013, sequence version 1.
DT 27-MAR-2024, entry version 65.
DE RecName: Full=Fatty acid synthase {ECO:0000256|ARBA:ARBA00018769};
DE EC=2.3.1.85 {ECO:0000256|ARBA:ARBA00012873};
GN ORFNames=CAPTEDRAFT_89190 {ECO:0000313|EMBL:ELT99721.1};
OS Capitella teleta (Polychaete worm).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Annelida; Polychaeta;
OC Sedentaria; Scolecida; Capitellidae; Capitella.
OX NCBI_TaxID=283909 {ECO:0000313|EMBL:ELT99721.1};
RN [1] {ECO:0000313|Proteomes:UP000014760}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=I ESC-2004 {ECO:0000313|Proteomes:UP000014760};
RA Hellsten U., Grimwood J., Chapman J.A., Shapiro H., Aerts A., Otillar R.P.,
RA Terry A.Y., Boore J.L., Simakov O., Marletaz F., Cho S.-J.,
RA Edsinger-Gonzales E., Havlak P., Kuo D.-H., Larsson T., Lv J., Arendt D.,
RA Savage R., Osoegawa K., de Jong P., Lindberg D.R., Seaver E.C.,
RA Weisblat D.A., Putnam N.H., Grigoriev I.V., Rokhsar D.S.;
RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ELT99721.1, ECO:0000313|Proteomes:UP000014760}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=I ESC-2004 {ECO:0000313|EMBL:ELT99721.1,
RC ECO:0000313|Proteomes:UP000014760};
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
RN [3] {ECO:0000313|EnsemblMetazoa:CapteP89190}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JUN-2015) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AMQN01009914; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KB306576; ELT99721.1; -; Genomic_DNA.
DR STRING; 283909.R7U7S4; -.
DR EnsemblMetazoa; CapteT89190; CapteP89190; CapteG89190.
DR HOGENOM; CLU_000022_31_7_1; -.
DR OMA; RYPWQHG; -.
DR UniPathway; UPA00094; -.
DR Proteomes; UP000014760; Unassembled WGS sequence.
DR GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:UniProtKB-UniPathway.
DR CDD; cd05195; enoyl_red; 1.
DR CDD; cd08954; KR_1_FAS_SDR_x; 1.
DR CDD; cd00833; PKS; 1.
DR Gene3D; 3.30.70.3290; -; 1.
DR Gene3D; 3.40.47.10; -; 1.
DR Gene3D; 1.10.1200.10; ACP-like; 1.
DR Gene3D; 3.40.366.10; Malonyl-Coenzyme A Acyl Carrier Protein, domain 2; 1.
DR Gene3D; 3.90.180.10; Medium-chain alcohol dehydrogenases, catalytic domain; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR Gene3D; 3.10.129.110; Polyketide synthase dehydratase; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR001227; Ac_transferase_dom_sf.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR014043; Acyl_transferase.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR013149; ADH-like_C.
DR InterPro; IPR049391; FAS_pseudo-KR.
DR InterPro; IPR011032; GroES-like_sf.
DR InterPro; IPR018201; Ketoacyl_synth_AS.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR016036; Malonyl_transacylase_ACP-bd.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR032821; PKS_assoc.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR042104; PKS_dehydratase_sf.
DR InterPro; IPR020807; PKS_DH.
DR InterPro; IPR049552; PKS_DH_N.
DR InterPro; IPR020843; PKS_ER.
DR InterPro; IPR013968; PKS_KR.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR43775:SF7; FATTY ACID SYNTHASE; 1.
DR Pfam; PF00698; Acyl_transf_1; 1.
DR Pfam; PF00107; ADH_zinc_N; 1.
DR Pfam; PF21149; FAS_pseudo-KR; 1.
DR Pfam; PF16197; KAsynt_C_assoc; 1.
DR Pfam; PF00109; ketoacyl-synt; 1.
DR Pfam; PF02801; Ketoacyl-synt_C; 1.
DR Pfam; PF08659; KR; 1.
DR Pfam; PF21089; PKS_DH_N; 1.
DR Pfam; PF00550; PP-binding; 1.
DR SMART; SM00827; PKS_AT; 1.
DR SMART; SM00826; PKS_DH; 1.
DR SMART; SM00829; PKS_ER; 1.
DR SMART; SM00822; PKS_KR; 1.
DR SMART; SM00825; PKS_KS; 1.
DR SMART; SM00823; PKS_PP; 1.
DR SUPFAM; SSF47336; ACP-like; 1.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 1.
DR SUPFAM; SSF50129; GroES-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 2.
DR SUPFAM; SSF55048; Probable ACP-binding domain of malonyl-CoA ACP transacylase; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR SUPFAM; SSF53901; Thiolase-like; 2.
DR PROSITE; PS50075; CARRIER; 1.
DR PROSITE; PS00606; KS3_1; 1.
DR PROSITE; PS52004; KS3_2; 1.
PE 4: Predicted;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW NADP {ECO:0000256|ARBA:ARBA00022857};
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000014760};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 1..321
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 2028..2105
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
SQ SEQUENCE 2112 AA; 231523 MW; DF556E6381E7E76B CRC64;
MSKLLLSGVN LHSLRGSKTG VFIGCIGSEC HEVWPNDPEK ITGYELTGCA RSMFANRLSF
FFDFKGPSYV IDTACSSSLL ALNEALQSIR AGQCDSAVVG GCNLCLKPQT SLQFQNLNML
SPDGSCKSFD SEANGYCRSE AVVCVFLQRE VSAKRIYATL VHSNTNCDGN KEQGVTFPSG
DIQKKLLKSV YAEAGINPAH VSYVEAHGTG TPAGDPQELN SITEVFCTAD RRGPLLIGST
KSNMGHPEPV AGLAALAKII IAIEDGAIPA NLHYKSPNPD IPGLADGLLS VVSKRTAWEG
GYVGINSFGF GGSNVHAILK SNVTAAAPKH PAAEKTRLVT LCGRTKDAVK SLLDKVNSNA
ANVELQSLLQ LNSDASHPYR GYRLLNHDGD VQEIRESAGE QRPVWYVFSG MGSQWLGMGR
DLMNIGTFKT SILRSSEVLN KYSIDLYHLL MNGDDSTYDS TLNSFICIVA IQIALVDVLR
ELGIQPDGLV GHSVGELGCG YADGGLTAEE AILAAYWRGQ CIQEANLPPG GMAAVGMTWE
ETKRRCPEGV VAACHNSEDT VTISGPLEAV NKCIKQLKSE DIFAKNVNSA GVAFHSPCIA
KVAPALKTAL LEVIKDPKPR SARWISSSIP ADRWNADIAK MCSAEYHVNN LVSPVLFQEA
LQHVSSNAII VEIAPHCLLQ AILKRSLSQN CTFVGLMKRN HQDNLEFLLS NLGKLYNAGV
NFDPLALFAP VKFPVSTGTP NIASFVQWDH TQSWDVPTLN MFYSSGTGGS TSCVFEVDTA
SNPEDKYLIG HMLDGRVLFP ATGYLELVWR ALAKITGQGY KQMSVAFEDV HFHRATILPK
SGAIKFFVTI TPVTGQFEVS ESDALVLDGR ISVLNSPVDD ALTHGKETEH VEDSVIHLDS
NDVYKELRLR GYEYAGMFQG ILSATNRGDE GYLAWMDNWV TFVDTMLQMQ ILNIPGRSHR
LPTRIESLNI DPQVHQSHVM TVKNGQKAVK VVVDSDLDTC SAGGVQILGL HATVAPRRQQ
TQADPVIEQQ KFIPYSESLN ATDELKIYAE ACEASAGKIL KKMPGFEFEN KVQNFDAAVE
TSGALLDTLK CLEALSYDDT FVKNIENILE ARKEELTDDK LLRLSQSERM LKTLMDIVHE
NYHRGPENLR IIEYGATGVF NRVIPFMRTH STLKVGYTVT GPHIDQLPIE HLMSMDVKSL
AWTLHQPLTK VLRDVDVVIL DGSLHTQADL CEALRTIKGL LRPDGFILII EPTRHFSIPL
VLSGLETDLT QMKDLAMRSD GPFCNEETWM QIFTDAELQV VAEKSNQVLN TLYLCRPVKD
VPLQKTVIDI DDLGFHWVEE VKVAMAATEV EQGQRIWLRS EKGSYSGIVG MVKSLRMEDG
GTRIRCLFNA CGSSRLPGLE SKEFLDISRK DLVMNVCVNN RWGSFRHMSL QISIRITTEY
ACISAHTRGD LSSLKWVESS LKYFDSKSQP DKELCQVAYT SLNFRDIMLA TGKLAPEAIP
GALASQDCIL GMEFSGYNTK GESVMGLTPS KGLATVVDAT YNFLWPVPDS WSLEEAATVP
VVYATAYYAL VVRGKIRRGE RVLIHSGSGG VGQAAIAIAL RHGCEVFTTV GSQKKKQYLK
ERFPSLQDCH FSSSRDCTFR KDILKATRGK GVDVVLNSLS EEKLQASVRL LAQHGRFLEI
GKFDLSNNSS LGMAVFLRNI TFHGVLLDAL FESDNGDWST VYQLLEEGIG NHTVIPLKAT
TFEKEDVEGA FRFMAQGKHI GKVVVRIRGE QKQALPIPAI ARSTCHPSKT YILIGGLGGV
GLEVANWLVE RGARNLVLSS RSGIRNGYQS RSVTEWRNQG VNVAVLTSNV FEKHGAEDVI
EKAQTLGPVG GIFNMAMVLK DGLMNNQTID NFVKVAEPKV IATIHLDLCS RQMCKESLDW
FVVFSSDRSA HGAVGLANYA FANSALERIC EQRQRDGFPG IAIQWGAIGD VGVVMDNMEG
NEAIVGGTLP QRIGSCLIIL DAFLNTSSTT VFASRVLHDQ TKSQVSDHVN NRNVMAAVTY
ILGIQDPATL NPDATLGDLG LDSLMSSEMK QTLERDFDIM IPTREIRLLS LKKIYSMAEK
NTGVLQAFTN KY
//