ID R7UAA4_CAPTE Unreviewed; 895 AA.
AC R7UAA4;
DT 24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2013, sequence version 1.
DT 24-JAN-2024, entry version 43.
DE RecName: Full=Importin N-terminal domain-containing protein {ECO:0000259|PROSITE:PS50166};
GN ORFNames=CAPTEDRAFT_126125 {ECO:0000313|EMBL:ELU00071.1};
OS Capitella teleta (Polychaete worm).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Annelida; Polychaeta;
OC Sedentaria; Scolecida; Capitellidae; Capitella.
OX NCBI_TaxID=283909 {ECO:0000313|EMBL:ELU00071.1};
RN [1] {ECO:0000313|Proteomes:UP000014760}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=I ESC-2004 {ECO:0000313|Proteomes:UP000014760};
RA Hellsten U., Grimwood J., Chapman J.A., Shapiro H., Aerts A., Otillar R.P.,
RA Terry A.Y., Boore J.L., Simakov O., Marletaz F., Cho S.-J.,
RA Edsinger-Gonzales E., Havlak P., Kuo D.-H., Larsson T., Lv J., Arendt D.,
RA Savage R., Osoegawa K., de Jong P., Lindberg D.R., Seaver E.C.,
RA Weisblat D.A., Putnam N.H., Grigoriev I.V., Rokhsar D.S.;
RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ELU00071.1, ECO:0000313|Proteomes:UP000014760}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=I ESC-2004 {ECO:0000313|EMBL:ELU00071.1,
RC ECO:0000313|Proteomes:UP000014760};
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
RN [3] {ECO:0000313|EnsemblMetazoa:CapteP126125}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JUN-2015) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the importin beta family. Importin beta-2
CC subfamily. {ECO:0000256|ARBA:ARBA00038423}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AMQN01009780; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KB306204; ELU00071.1; -; Genomic_DNA.
DR AlphaFoldDB; R7UAA4; -.
DR STRING; 283909.R7UAA4; -.
DR EnsemblMetazoa; CapteT126125; CapteP126125; CapteG126125.
DR HOGENOM; CLU_008136_1_0_1; -.
DR OMA; AQEGAMS; -.
DR Proteomes; UP000014760; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR GO; GO:0006606; P:protein import into nucleus; IEA:InterPro.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 2.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR000357; HEAT.
DR InterPro; IPR001494; Importin-beta_N.
DR InterPro; IPR040122; Importin_beta.
DR PANTHER; PTHR10527:SF3; FI21453P1-RELATED; 1.
DR PANTHER; PTHR10527; IMPORTIN BETA; 1.
DR Pfam; PF02985; HEAT; 2.
DR Pfam; PF13513; HEAT_EZ; 1.
DR Pfam; PF03810; IBN_N; 1.
DR SMART; SM00913; IBN_N; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR PROSITE; PS50166; IMPORTIN_B_NT; 1.
PE 3: Inferred from homology;
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000014760};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 33..101
FT /note="Importin N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS50166"
FT REGION 327..368
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 327..357
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 895 AA; 101322 MW; 1CAC0846A8F84952 CRC64;
MAGSWQPEET GLQQILQLLR ESQSPDTNTQ RLVQQKLEEL NNFPDFNNYL IFVLTKLVTE
DEPTRSLSGL ILKNNIRVHF EKFPPEVTEF IKAECLTAIG DPSPLIRATI GILITTIAAK
GGLENWNDLL PNLCQYLDSD DYNVCEGAFG ALQKICEDSA EALDSESLNR PLNVLIPKFL
QFFKHSSAKI RSHAIACVNQ FIIGRTQALM VHIDSFIENL FFLASDEDPE VRKNVCRALV
MLVEVRMDRL IPQINHIVEY MLMRTLDPDD TVALEACEFW LSLAEQPICR EVLSPHIERL
VPILVRGMKY SEIDIILLRG DVEEDETIPD KESEIKPRFH KSKTHQISKS SSEEVCHGDG
DDFDDDDDMD DDDALSDWNL RKCSAAALDV LANVFHDILL PVLLPILKET LFHQDWEIKE
SGILVLGAIA EGCMSGMTPH LPELTPYLIQ CLSDKKALVR SIACWTLSRY AHWVVQQPHE
QYLKPLMTEL LKRILDANKR VQEAACSAFA TLEEEACTEL VPYLGFILET LVYAFGKYQH
KNLLILYDAI GTLADSVGNH LNKSEYINLL MPPLIQKWNH LKDTDKDLFP LLECLSSVAT
ALQSGFLPYC EPVFGRCVSL IEQTLNQNFA NLSNPEQYEA PDKDFMIVAL DLLSGLAEGL
GHHIETLVAD SNLIKFLYQC MQDPMPEVRQ SSFALLGDLT KACFQHVKPF IGDFMPILGA
NLNPEYISVC NNATWAIGEI SIKMGADMRE YIPLVLNPLI QISNRPNTPK TLLENTAITI
GRLGLVCPQE VAPVLHQFIR QWCTSLRNIR DNEEKDSAFR GVCTMISVNP AGVVQDFIFF
CDAVASWVCP KDDLKEMFYK ILHSFKDRVG DENWKRFSEQ FPVPLRERLQ VVYGL
//
