ID R7UZZ9_CAPTE Unreviewed; 1002 AA.
AC R7UZZ9;
DT 24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2013, sequence version 1.
DT 27-MAR-2024, entry version 44.
DE RecName: Full=CARD domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=CAPTEDRAFT_188650 {ECO:0000313|EMBL:ELU11842.1};
OS Capitella teleta (Polychaete worm).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Annelida; Polychaeta;
OC Sedentaria; Scolecida; Capitellidae; Capitella.
OX NCBI_TaxID=283909 {ECO:0000313|EMBL:ELU11842.1};
RN [1] {ECO:0000313|Proteomes:UP000014760}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=I ESC-2004 {ECO:0000313|Proteomes:UP000014760};
RA Hellsten U., Grimwood J., Chapman J.A., Shapiro H., Aerts A., Otillar R.P.,
RA Terry A.Y., Boore J.L., Simakov O., Marletaz F., Cho S.-J.,
RA Edsinger-Gonzales E., Havlak P., Kuo D.-H., Larsson T., Lv J., Arendt D.,
RA Savage R., Osoegawa K., de Jong P., Lindberg D.R., Seaver E.C.,
RA Weisblat D.A., Putnam N.H., Grigoriev I.V., Rokhsar D.S.;
RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ELU11842.1, ECO:0000313|Proteomes:UP000014760}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=I ESC-2004 {ECO:0000313|EMBL:ELU11842.1,
RC ECO:0000313|Proteomes:UP000014760};
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
RN [3] {ECO:0000313|EnsemblMetazoa:CapteP188650}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JUN-2015) to UniProtKB.
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DR EMBL; AMQN01005605; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KB296374; ELU11842.1; -; Genomic_DNA.
DR AlphaFoldDB; R7UZZ9; -.
DR STRING; 283909.R7UZZ9; -.
DR EnsemblMetazoa; CapteT188650; CapteP188650; CapteG188650.
DR HOGENOM; CLU_009460_2_1_1; -.
DR OMA; QNYLEHL; -.
DR Proteomes; UP000014760; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR GO; GO:0042981; P:regulation of apoptotic process; IEA:InterPro.
DR CDD; cd01671; CARD; 1.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR InterPro; IPR001315; CARD.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR007111; NACHT_NTPase.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR46844; SLR5058 PROTEIN; 1.
DR PANTHER; PTHR46844:SF1; SLR5058 PROTEIN; 1.
DR Pfam; PF00619; CARD; 1.
DR Pfam; PF05729; NACHT; 1.
DR SMART; SM00114; CARD; 1.
DR SUPFAM; SSF47986; DEATH domain; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF52047; RNI-like; 1.
DR PROSITE; PS50209; CARD; 1.
DR PROSITE; PS50837; NACHT; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Immunity {ECO:0000256|ARBA:ARBA00022859};
KW Innate immunity {ECO:0000256|ARBA:ARBA00022588};
KW Reference proteome {ECO:0000313|Proteomes:UP000014760};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 1..95
FT /note="CARD"
FT /evidence="ECO:0000259|PROSITE:PS50209"
FT DOMAIN 174..297
FT /note="NACHT"
FT /evidence="ECO:0000259|PROSITE:PS50837"
SQ SEQUENCE 1002 AA; 116375 MW; D6706CE6C4161D3F CRC64;
MESHHIECLK KNRVFLCDKI SLSADLYAHL GEMDVITDDH LNEIQNIKRN GTTKEAVLHF
LTAILPKRRP ETFDLFLEAL RTSGQKHVAE RLDEWLKESD QNSKDQTIPQ ELQSYYKRKL
QSIIPMPWWK NIQLSLTEMC VERQLRKLIN SKGEEKMIPI DRLFTHEEDQ TIPRRLLIEG
DPGIGKSILC QKLAFEWSIQ SCGDRCRTSC IHCFDLTFYL NARQFMNENT VADVVLKSDL
LPKDLGISST RMTEVIKATN VLFIIDGYDE AFSQNSLLDQ LLKGDMFRHK TVLLTSRRNF
LQDNINHIDC VYSIEGYDKH QQVEHVRRFT EHEKIPFSRL NSLLESNEVE NLGKNPLMLT
LLCLLHTEKD VRTRTQTELY SEIHDFILRK VIERMKLTEE DIEHRLLRPL YQLAFEAFEN
GEDVLLERDF ERAGLSSEEV CEVGYLTRDI LIRGIKQGWR YSFTHRTFLE FLAAKHLVLM
AAEERLKWLR KYYFRPNSNR VEEVQRLHFS LLFRVAENVV AFLFGLHPDV LLQMASTVID
ATLDKDFVGS FYNSLSLPDG SLCPPSHVFC RLLCELNTMP PVLVTTIAKR LSPHRAVAVG
FNCSDRCIKG MAIMYNLCLP EPISISLTIH TQQYTQTNIP LLRELVNFSI FDRVCIHVTD
NNHLKNSLHA LRIGQADSIR NVKIVKSSVC KDIAPPALPF GDDLRGISLM KYDKVSTRRF
LEIVSKKPLI ELGVLYCDLD DRCKRCLSNL LLNHDLQSVI LVSTNQHMGR FLRRLTGLDK
LQKLRISLKN MDQAERHNFE KILKKNTLQE LSLLHCQYFA DLCNILSNHF SRMTALRYLR
VINLPDFQPI DRILCNLHLL RLQEFHIQYV LNDDNLNAIT GAIRSWPNLQ VLWIHDRSHD
LSFADNNVRI SLTEGAVRLL IKAIASCRSL NRLALKGLQI QDRLIPEMCK MLKSLIQLTE
FQLTYIHDET LTEEGFMPLQ QYADQRVGFN CIDYKTFVKE CS
//
