ID R7VQR2_COLLI Unreviewed; 951 AA.
AC R7VQR2;
DT 24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2013, sequence version 1.
DT 27-MAR-2024, entry version 49.
DE SubName: Full=Nucleotide-binding oligomerization domain containing 1 {ECO:0000313|EMBL:PKK32277.1};
GN Name=NOD1 {ECO:0000313|EMBL:PKK32277.1};
GN ORFNames=A306_00002744 {ECO:0000313|EMBL:PKK32277.1};
OS Columba livia (Rock dove).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Columbiformes; Columbidae; Columba.
OX NCBI_TaxID=8932 {ECO:0000313|EMBL:PKK32277.1, ECO:0000313|Proteomes:UP000053872};
RN [1] {ECO:0000313|EMBL:PKK32277.1, ECO:0000313|Proteomes:UP000053872}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC TISSUE=Blood {ECO:0000313|EMBL:PKK32277.1};
RX PubMed=23371554; DOI=10.1126/science.1230422;
RA Shapiro M.D., Kronenberg Z., Li C., Domyan E.T., Pan H., Campbell M.,
RA Tan H., Huff C.D., Hu H., Vickrey A.I., Nielsen S.C., Stringham S.A.,
RA Hu H., Willerslev E., Gilbert M.T., Yandell M., Zhang G., Wang J.;
RT "Genomic diversity and evolution of the head crest in the rock pigeon.";
RL Science 339:1063-1067(2013).
CC -!- SUBCELLULAR LOCATION: Basolateral cell membrane
CC {ECO:0000256|ARBA:ARBA00004187}. Cell membrane
CC {ECO:0000256|ARBA:ARBA00004193}; Lipid-anchor
CC {ECO:0000256|ARBA:ARBA00004193}. Lateral cell membrane
CC {ECO:0000256|ARBA:ARBA00004124}. Membrane
CC {ECO:0000256|ARBA:ARBA00004635}; Lipid-anchor
CC {ECO:0000256|ARBA:ARBA00004635}.
CC -!- SIMILARITY: Belongs to the NOD1-NOD2 family.
CC {ECO:0000256|ARBA:ARBA00038296}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PKK32277.1}.
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DR EMBL; AKCR02000004; PKK32277.1; -; Genomic_DNA.
DR RefSeq; XP_005510067.1; XM_005510010.2.
DR AlphaFoldDB; R7VQR2; -.
DR STRING; 8932.R7VQR2; -.
DR GeneID; 102097171; -.
DR KEGG; clv:102097171; -.
DR CTD; 10392; -.
DR eggNOG; KOG4308; Eukaryota.
DR InParanoid; R7VQR2; -.
DR OrthoDB; 3087860at2759; -.
DR Proteomes; UP000053872; Unassembled WGS sequence.
DR GO; GO:0016323; C:basolateral plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0016328; C:lateral plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR GO; GO:0042981; P:regulation of apoptotic process; IEA:InterPro.
DR CDD; cd08324; CARD_NOD1_CARD4; 1.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 2.
DR InterPro; IPR001315; CARD.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR007111; NACHT_NTPase.
DR InterPro; IPR041267; NLRP_HD2.
DR InterPro; IPR041075; NOD2_WH.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR24106; NACHT, LRR AND CARD DOMAINS-CONTAINING; 1.
DR PANTHER; PTHR24106:SF278; RNI-LIKE SUPERFAMILY PROTEIN; 1.
DR Pfam; PF00619; CARD; 1.
DR Pfam; PF13516; LRR_6; 3.
DR Pfam; PF05729; NACHT; 1.
DR Pfam; PF17776; NLRC4_HD2; 1.
DR Pfam; PF17779; NOD2_WH; 1.
DR SMART; SM00368; LRR_RI; 7.
DR SUPFAM; SSF47986; DEATH domain; 1.
DR SUPFAM; SSF52047; RNI-like; 1.
DR PROSITE; PS50209; CARD; 1.
DR PROSITE; PS50837; NACHT; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Immunity {ECO:0000256|ARBA:ARBA00022859};
KW Innate immunity {ECO:0000256|ARBA:ARBA00022588};
KW Lipoprotein {ECO:0000256|ARBA:ARBA00023288};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Palmitate {ECO:0000256|ARBA:ARBA00023139};
KW Reference proteome {ECO:0000313|Proteomes:UP000053872};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}.
SQ SEQUENCE 951 AA; 108507 MW; 914DF9CD756C930B CRC64;
MEGQLCANPE ISVKKAPGAS PPSFIALLKV HRELLVSRIR NTQCLIDNLI KNDYFSTEDA
EIVVQFPTQA DKVRKILDLV QSKGEEVSEY FILVLQKVTD AYYELQPWLD EIGYKPSESI
CSKPVVNTDP VSRYCQKLRY ELGRDSKFVT SYAQREEMLL EEIYSDSIME LVSFTNDSLG
KVCQLEALFD DAVGVINEDG ETIYVFGDAG IGKSILLQKI QSLWAKKELD IGAKFFFRFL
CRMFSCFKED EVICLKDLLF KYNCYPDQDP TEVFHYILQF PHTVLFTFDG FDEIYSNFDL
SSVPEMCSPH EAIHPLVLLV SLLRGKLLKG SKKILTARTG TEIQKNIIRK KVLLRGFSSN
NLKQYTTMFF KDMGQQTLVL NQLEANPFLC SLCSVPLFCW IIFKCYEHFH SMFDSHELPA
CSVTLTDVFL LMIEVHLNRS LKTSLLKNNT RSQAEMFKSR KETLLALGKM ARKGMENSSF
VFEQEEVSSA SISEEDLQLG FLRTVKGYSG CDNQSTYEFL HLTLQSFFTA LFLVMEEKVD
AKELLHFFNE CSSTETAQPT CLPIPWLKKQ IAGKDPFRNN EHFHFTNLFL CGLLSRSKQK
LFRHLVLPTV IKRKRRALIT YLGESMKSHL KGLTRSRLQN YNQLQVQPNF VWMLRCLYET
QNEKVGKLAA KRMHANYVKL TYCNASSADC SAISFVMHHF QKRLALDLDN NNINDYGVKE
LLPCFSKLAV IRLSVNQVTD HGVRILYEEL SKYQTVTYLG LYNNQITDVG AKYVAKLIEE
CSSLEYVKIG ANKITSEGGK CLAQAIQKSK TMFEIGMWGN HVGDEGAKAF AQALRNHPTL
TNVSLAFNGI TTEGGKSIAE AMQHNNSVRI FWLTKNELDD EAAMSFAEML KVNKKLVHLW
LIQNRITAEG VKYLSEALKE NTAIKEVCLN GNLISQEEAK AFENDKRIVC F
//
