ID R7VT03_COLLI Unreviewed; 927 AA.
AC R7VT03;
DT 24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2013, sequence version 1.
DT 27-MAR-2024, entry version 43.
DE RecName: Full=Netrin receptor UNC5 {ECO:0000256|RuleBase:RU367033};
GN Name=UNC5B {ECO:0000313|EMBL:PKK28381.1};
GN ORFNames=A306_00005239 {ECO:0000313|EMBL:PKK28381.1};
OS Columba livia (Rock dove).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Columbiformes; Columbidae; Columba.
OX NCBI_TaxID=8932 {ECO:0000313|EMBL:PKK28381.1, ECO:0000313|Proteomes:UP000053872};
RN [1] {ECO:0000313|EMBL:PKK28381.1, ECO:0000313|Proteomes:UP000053872}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC TISSUE=Blood {ECO:0000313|EMBL:PKK28381.1};
RX PubMed=23371554; DOI=10.1126/science.1230422;
RA Shapiro M.D., Kronenberg Z., Li C., Domyan E.T., Pan H., Campbell M.,
RA Tan H., Huff C.D., Hu H., Vickrey A.I., Nielsen S.C., Stringham S.A.,
RA Hu H., Willerslev E., Gilbert M.T., Yandell M., Zhang G., Wang J.;
RT "Genomic diversity and evolution of the head crest in the rock pigeon.";
RL Science 339:1063-1067(2013).
CC -!- FUNCTION: Receptor for netrin required for axon guidance. Mediates axon
CC repulsion of neuronal growth cones in the developing nervous system
CC upon ligand binding. {ECO:0000256|RuleBase:RU367033}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251,
CC ECO:0000256|RuleBase:RU367033}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004251, ECO:0000256|RuleBase:RU367033}.
CC Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane
CC protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the unc-5 family.
CC {ECO:0000256|ARBA:ARBA00009844, ECO:0000256|RuleBase:RU367033}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PKK28381.1}.
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DR EMBL; AKCR02000016; PKK28381.1; -; Genomic_DNA.
DR RefSeq; XP_005506516.1; XM_005506459.1.
DR AlphaFoldDB; R7VT03; -.
DR STRING; 8932.R7VT03; -.
DR GeneID; 102092905; -.
DR KEGG; clv:102092905; -.
DR CTD; 219699; -.
DR eggNOG; KOG1480; Eukaryota.
DR InParanoid; R7VT03; -.
DR OrthoDB; 2971005at2759; -.
DR Proteomes; UP000053872; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005042; F:netrin receptor activity; IEA:UniProtKB-UniRule.
DR CDD; cd08802; Death_UNC5B; 1.
DR Gene3D; 2.60.220.30; -; 1.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR Gene3D; 2.20.100.10; Thrombospondin type-1 (TSP1) repeat; 2.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR000488; Death_domain.
DR InterPro; IPR042156; Death_UNC5B.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR000884; TSP1_rpt.
DR InterPro; IPR036383; TSP1_rpt_sf.
DR InterPro; IPR037936; UNC5.
DR InterPro; IPR033772; UPA.
DR InterPro; IPR000906; ZU5_dom.
DR PANTHER; PTHR12582; NETRIN RECEPTOR UNC5; 1.
DR PANTHER; PTHR12582:SF6; NETRIN RECEPTOR UNC5B; 1.
DR Pfam; PF00531; Death; 1.
DR Pfam; PF07679; I-set; 1.
DR Pfam; PF00090; TSP_1; 2.
DR Pfam; PF17217; UPA; 1.
DR Pfam; PF00791; ZU5; 1.
DR PRINTS; PR01705; TSP1REPEAT.
DR SMART; SM00005; DEATH; 1.
DR SMART; SM00409; IG; 1.
DR SMART; SM00408; IGc2; 1.
DR SMART; SM00209; TSP1; 2.
DR SMART; SM00218; ZU5; 1.
DR SUPFAM; SSF47986; DEATH domain; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 2.
DR SUPFAM; SSF82895; TSP-1 type 1 repeat; 2.
DR PROSITE; PS50017; DEATH_DOMAIN; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS50092; TSP1; 2.
DR PROSITE; PS51145; ZU5; 1.
PE 3: Inferred from homology;
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473,
KW ECO:0000256|RuleBase:RU367033};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319,
KW ECO:0000256|RuleBase:RU367033};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU367033};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU367033};
KW Reference proteome {ECO:0000313|Proteomes:UP000053872};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU367033};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU367033}.
FT TRANSMEM 355..380
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU367033"
SQ SEQUENCE 927 AA; 102907 MW; 7D4B595B9A51DB9D CRC64;
MVPRDPLAGL EYSDVLPDSF PSAPAETLPH FLLEPQDAYI VKNKPVELVC RANPATQIYF
KCNGEWVNQN DHVTKESLDE VTGLLVREVQ IEVSRQQVEE LFGLEDYWCQ CVAWSSAGTT
KSRRAYVRIA YLRKNFDQEP LGKEVPLEQE VLLQCRPPEG VPQAEVEWLR NEDVIDPTQD
TNFLITIDHN LIIKQARLLD TANYTCMAKN IVAKRRSTTA AVIVYVNGGW STWSEWSPCN
NRCGRGWQKR TRTCTNPAPL NGGSFCDGQP FQKITCTTLC PVDGAWTEWS KWSACSTECT
HWRSRECAAP APRNGGKDCS GVLLDSKNCT DGLCLQNKRV LSEPKSHLLE ATGDVALYAG
LVVAIFVFIV ILMAVGVVVY RRRRRDFDTD ITDSSAALTG GFHPVNFKTS RHDNPQLLHP
SMQPDLTASA GVYRGPMYAL QDSSDKIPMT NSPLLDPLPN LKIKVYNSST TSSSPGLHDG
TDLLGGVPTT GTYPGDNTRD SHFANVRSKG LGSQHLLSLP REHSYSASGT FGYLGGRLTI
PGTGVSLLVP HGAIPQGKFY EMYLVLNKAE SALLPSEGTQ TVLSPTVSCG PTGLLLCRPV
VLTIPHCADV ASSDWIYQLK TQSHQGNWEE VVTLDEETLN TPCYCQLEAK SCHVLLDQLG
TYVFVGESYS RSAIKRLQLA IFAPTVCTSL EYSLKVYCLE DTPDALKEVL ELERTLGGYL
LEEPKPLPFK DSYHNLRLSI HDIPHALWRS KLLAKYQEIP FYHIWSGSQR ALHCTFTLER
YSQASTELTC KICVRQVEGE GQIFQLHVTL GEHASSFDTL HSHHSGTTTT TQLGPYAFKI
PLSIRQKICN SLDAPNSRGN DWRLLAQKLS MDRYLNYFAT KASPTGVLLD LWEAQHQDDG
DLNTLASALE EMGKSEMLVV MATEGDC
//
