ID R7Y1V6_9ACTN Unreviewed; 361 AA.
AC R7Y1V6;
DT 24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2013, sequence version 1.
DT 27-MAR-2024, entry version 42.
DE SubName: Full=Alcohol dehydrogenase {ECO:0000313|EMBL:EON25225.1};
GN ORFNames=CF8_0757 {ECO:0000313|EMBL:EON25225.1};
OS Nocardioides sp. CF8.
OC Bacteria; Actinomycetota; Actinomycetes; Propionibacteriales;
OC Nocardioidaceae; Nocardioides.
OX NCBI_TaxID=110319 {ECO:0000313|EMBL:EON25225.1, ECO:0000313|Proteomes:UP000015971};
RN [1] {ECO:0000313|EMBL:EON25225.1, ECO:0000313|Proteomes:UP000015971}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CF8 {ECO:0000313|EMBL:EON25225.1,
RC ECO:0000313|Proteomes:UP000015971};
RX PubMed=23833136;
RA Kimbrel J.A., Chang J., Arp D.J., Sayavedra-Soto L.A.;
RT "The Draft Genome Sequence of Nocardioides sp. Strain CF8 Reveals the Scope
RT of Its Metabolic Capabilities.";
RL Genome Announc. 1:e00439-e00439(2013).
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|ARBA:ARBA00001947,
CC ECO:0000256|RuleBase:RU361277};
CC -!- SIMILARITY: Belongs to the zinc-containing alcohol dehydrogenase
CC family. {ECO:0000256|RuleBase:RU361277}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EON25225.1}.
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DR EMBL; ASEP01000025; EON25225.1; -; Genomic_DNA.
DR RefSeq; WP_010831783.1; NZ_CM001852.1.
DR AlphaFoldDB; R7Y1V6; -.
DR STRING; 110319.CF8_0757; -.
DR PATRIC; fig|110319.3.peg.1338; -.
DR eggNOG; COG1062; Bacteria.
DR HOGENOM; CLU_026673_14_1_11; -.
DR OrthoDB; 334894at2; -.
DR Proteomes; UP000015971; Chromosome.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR CDD; cd08279; Zn_ADH_class_III; 1.
DR Gene3D; 3.90.180.10; Medium-chain alcohol dehydrogenases, catalytic domain; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR013149; ADH-like_C.
DR InterPro; IPR013154; ADH-like_N.
DR InterPro; IPR002328; ADH_Zn_CS.
DR InterPro; IPR011032; GroES-like_sf.
DR InterPro; IPR017816; MycoS_dep_FDH.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR020843; PKS_ER.
DR NCBIfam; TIGR03451; mycoS_dep_FDH; 1.
DR PANTHER; PTHR43350; NAD-DEPENDENT ALCOHOL DEHYDROGENASE; 1.
DR PANTHER; PTHR43350:SF19; RIBULOSE-5-PHOSPHATE REDUCTASE; 1.
DR Pfam; PF08240; ADH_N; 1.
DR Pfam; PF00107; ADH_zinc_N; 1.
DR SMART; SM00829; PKS_ER; 1.
DR SUPFAM; SSF50129; GroES-like; 2.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS00059; ADH_ZINC; 1.
PE 3: Inferred from homology;
KW Metal-binding {ECO:0000256|RuleBase:RU361277};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000015971};
KW Zinc {ECO:0000256|RuleBase:RU361277}.
FT DOMAIN 13..359
FT /note="Enoyl reductase (ER)"
FT /evidence="ECO:0000259|SMART:SM00829"
SQ SEQUENCE 361 AA; 37385 MW; D8E5C52E7DF08E00 CRC64;
MQQVKGVVAR AKGQPVTVET INIPDPGPGE AVVKVQACGV CHTDLHYREG GINDEFPFLL
GHEAAGIVES VGDGVTGLEA GDFVVLNWRA VCGSCRACHR GEPWYCFATH NATQKMTLED
GTELSPALGI GSFAEKTLVA AGQCTKVDPS ARAAAVGLLG CGVMAGLGAA INTGNVSRGK
SVAVIGCGGV GMAAIAGSAL AGASKIIAVD IDDTKLEWAR SMGATDTINS KGIDPVAAIQ
ALTDGNGADV VIDAVGRPET WKQAFYARDL AGTVVLVGVP TPDMKIPDIP LIDVFGRGGA
LKSSWYGDCL PSRDFPMLVD LYQQGRLDLD AFVTEEIGLG DVEAAFEKMH DGSVLRSVVV
F
//
