ID R7YWG4_CONA1 Unreviewed; 1152 AA.
AC R7YWG4;
DT 24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2013, sequence version 1.
DT 27-MAR-2024, entry version 50.
DE RecName: Full=Xeroderma pigmentosum group C-complementing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=W97_05422 {ECO:0000313|EMBL:EON66178.1};
OS Coniosporium apollinis (strain CBS 100218) (Rock-inhabiting black yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Dothideomycetes;
OC Dothideomycetes incertae sedis; Coniosporium.
OX NCBI_TaxID=1168221 {ECO:0000313|EMBL:EON66178.1, ECO:0000313|Proteomes:UP000016924};
RN [1] {ECO:0000313|Proteomes:UP000016924}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 100218 {ECO:0000313|Proteomes:UP000016924};
RG The Broad Institute Genome Sequencing Platform;
RA Cuomo C., Gorbushina A., Noack S., Walker B., Young S.K., Zeng Q.,
RA Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Goldberg J., Griggs A., Gujja S.,
RA Hansen M., Howarth C., Imamovic A., Larimer J., McCowan C., Montmayeur A.,
RA Murphy C., Neiman D., Pearson M., Priest M., Roberts A., Saif S., Shea T.,
RA Sisk P., Sykes S., Wortman J., Nusbaum C., Birren B.;
RT "The genome sequence of Coniosporium apollinis CBS 100218.";
RL Submitted (JUN-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the XPC family. {ECO:0000256|ARBA:ARBA00009525}.
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DR EMBL; JH767578; EON66178.1; -; Genomic_DNA.
DR RefSeq; XP_007781495.1; XM_007783305.1.
DR AlphaFoldDB; R7YWG4; -.
DR STRING; 1168221.R7YWG4; -.
DR GeneID; 19902733; -.
DR eggNOG; KOG2179; Eukaryota.
DR HOGENOM; CLU_003639_0_1_1; -.
DR OMA; TWPGKTK; -.
DR OrthoDB; 181129at2759; -.
DR Proteomes; UP000016924; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003684; F:damaged DNA binding; IEA:InterPro.
DR GO; GO:0006289; P:nucleotide-excision repair; IEA:InterPro.
DR Gene3D; 2.20.20.110; Rad4, beta-hairpin domain BHD1; 1.
DR Gene3D; 3.30.70.2460; Rad4, beta-hairpin domain BHD3; 1.
DR Gene3D; 3.90.260.10; Transglutaminase-like; 2.
DR InterPro; IPR018327; BHD_2.
DR InterPro; IPR004583; DNA_repair_Rad4.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR018325; Rad4/PNGase_transGLS-fold.
DR InterPro; IPR018326; Rad4_beta-hairpin_dom1.
DR InterPro; IPR018328; Rad4_beta-hairpin_dom3.
DR InterPro; IPR042488; Rad4_BHD3_sf.
DR InterPro; IPR036985; Transglutaminase-like_sf.
DR PANTHER; PTHR12135:SF0; DNA REPAIR PROTEIN COMPLEMENTING XP-C CELLS; 1.
DR PANTHER; PTHR12135; DNA REPAIR PROTEIN XP-C / RAD4; 1.
DR Pfam; PF10403; BHD_1; 1.
DR Pfam; PF10404; BHD_2; 1.
DR Pfam; PF10405; BHD_3; 1.
DR Pfam; PF03835; Rad4; 1.
DR SMART; SM01030; BHD_1; 1.
DR SMART; SM01031; BHD_2; 1.
DR SMART; SM01032; BHD_3; 1.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000016924}.
FT DOMAIN 633..692
FT /note="Rad4 beta-hairpin"
FT /evidence="ECO:0000259|SMART:SM01030"
FT DOMAIN 694..758
FT /note="Rad4 beta-hairpin"
FT /evidence="ECO:0000259|SMART:SM01031"
FT DOMAIN 765..839
FT /note="Rad4 beta-hairpin"
FT /evidence="ECO:0000259|SMART:SM01032"
FT REGION 1..118
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 383..483
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 977..1152
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 302..329
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 94..108
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 387..404
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 428..456
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1024..1044
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1051..1065
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1071..1087
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1109..1138
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1152 AA; 127355 MW; 93BC28DF41DCAE71 CRC64;
MPPFVPRKRH ASPSPSSSAP PAKRAATPRT NALEHRTKHA TPAKQSVFEA LDASTSRRTV
EDSKAFLNAL GESDSESGSE DGSGSSDDSD EFEDVLPAST RKPGEVRDDS SDEEEETWED
ALPAAHIHHA LHTPAAEPMG DLEITLNRDD MDVAANREAV LGKRQGPSKQ EKRIRIATHC
MHVQFLLFHN LIRNSWTCDK EVQSILVKGL SEGVKKEVER YRRAAGLPLE GDDEVQITRV
KKKVKGKGKK ADYRNQRDWG AEAEEMETEV PNMSGGDPLI RLLKYLAAYW KKRFKTTAPG
LRKQGYRSAA RLREELDQWN NEGVDVEAHG ERIADLKQFR ECAQKCEGSR DVGAQLFTAL
LRGLGLSARL LASLQPVGFG WSKSEEALPK KSSKTSHSKH HDPKNPQTTQ TNPEPGRIPA
IKSSKAPIRN SAGKTRSTAT NTTMNLDTAS SDELSSVPSD IDDDVSVADI TPRKSTPSKN
SPKRFDKDLP FPFYWTEVLS PTSNTYIPVD ALVLSTVASN PDLLYTFEPR GAAADKAKQV
IAYVIAYSAD GTAKDVTVRY LRKRIFPGKT KGVRMPAEKI PIYDRKGKVV RYEEQDWFKS
VILGYARPSS KRTLADQAED EGDLVPALSA KKATEEFVDT LTGLKASADY VLERHLRREE
ALLPSALPVR HFTTGKGDAA KTEPVYRRAD VVACKTTESW HKEGRQVIPG SQPMKLVPMR
AVTLQRKREI EEQQREAGGE KVKQGLFAQS QTEWIIPPPI EDGRIPRNAF GNIDVYVPTM
VPRGAVHVPL KSTAKLCRRL DIDYAEACVG FEFGKQRAVP VLLGVVVAVE HEDALIDAWE
AEEEEKRRKE DIKREARALA MWRKFMMGTR IVQRMREDYA IDENAAVPDN INPFTNRKSR
ATKISNGDLE KHAAHHDGGG FVWPEEVESG GFIRNGDEET SGGGFIVEQY HHQTAEEPSA
IGNGYLNTPI SLQAALKDTP QEPTEDSGTD NDMQESDDAT SPEPPPAKPA TRGRGRPRGR
AAKNTAGTSR TSRPSASTRN GAEPKYTSSE DEETLSSAAS DISSDEDQPE NGDSASERSE
KPAKRNRSGI SKPSPPPPEP TTNRVVPRRR AARKSETAVR SHYFSHDSEE ESPKKTRATG
RGRGRGRARG RV
//
