ID R7ZFF6_LYSSH Unreviewed; 646 AA.
AC R7ZFF6;
DT 24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2013, sequence version 1.
DT 27-MAR-2024, entry version 45.
DE SubName: Full=Tetracycline resistance protein tetP {ECO:0000313|EMBL:EON72744.1};
GN ORFNames=H131_11413 {ECO:0000313|EMBL:EON72744.1};
OS Lysinibacillus sphaericus OT4b.31.
OC Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae; Lysinibacillus.
OX NCBI_TaxID=1285586 {ECO:0000313|EMBL:EON72744.1, ECO:0000313|Proteomes:UP000013911};
RN [1] {ECO:0000313|EMBL:EON72744.1, ECO:0000313|Proteomes:UP000013911}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=OT4b.31 {ECO:0000313|EMBL:EON72744.1,
RC ECO:0000313|Proteomes:UP000013911};
RA Pena-Montenegro T.D., Dussan J.;
RT "Draft genome of the heavy metal tolerant bacterium Lysinibacillus
RT sphaericus strain OT4b.31.";
RL Submitted (APR-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Abolishes the inhibitory effect of tetracyclin on protein
CC synthesis by a non-covalent modification of the ribosomes.
CC {ECO:0000256|ARBA:ARBA00003987}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EON72744.1}.
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DR EMBL; AQPX01000017; EON72744.1; -; Genomic_DNA.
DR RefSeq; WP_010859228.1; NZ_KB933398.1.
DR AlphaFoldDB; R7ZFF6; -.
DR PATRIC; fig|1285586.5.peg.2318; -.
DR eggNOG; COG0480; Bacteria.
DR HOGENOM; CLU_002794_5_1_9; -.
DR OrthoDB; 9804431at2; -.
DR Proteomes; UP000013911; Unassembled WGS sequence.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
DR GO; GO:0006412; P:translation; IEA:UniProtKB-KW.
DR CDD; cd03711; Tet_C; 1.
DR Gene3D; 3.30.230.10; -; 1.
DR Gene3D; 3.30.70.240; -; 1.
DR Gene3D; 3.30.70.870; Elongation Factor G (Translational Gtpase), domain 3; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.40.30.10; Translation factors; 1.
DR InterPro; IPR035647; EFG_III/V.
DR InterPro; IPR000640; EFG_V-like.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR InterPro; IPR005225; Small_GTP-bd_dom.
DR InterPro; IPR000795; T_Tr_GTP-bd_dom.
DR InterPro; IPR035650; Tet_C.
DR InterPro; IPR009000; Transl_B-barrel_sf.
DR InterPro; IPR005517; Transl_elong_EFG/EF2_IV.
DR NCBIfam; TIGR00231; small_GTP; 1.
DR PANTHER; PTHR43261:SF1; RIBOSOME-RELEASING FACTOR 2, MITOCHONDRIAL; 1.
DR PANTHER; PTHR43261; TRANSLATION ELONGATION FACTOR G-RELATED; 1.
DR Pfam; PF00679; EFG_C; 1.
DR Pfam; PF03764; EFG_IV; 1.
DR Pfam; PF00009; GTP_EFTU; 1.
DR PRINTS; PR00315; ELONGATNFCT.
DR PRINTS; PR01037; TCRTETOQM.
DR SMART; SM00838; EFG_C; 1.
DR SMART; SM00889; EFG_IV; 1.
DR SUPFAM; SSF54980; EF-G C-terminal domain-like; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
DR SUPFAM; SSF50447; Translation proteins; 1.
DR PROSITE; PS51722; G_TR_2; 1.
PE 4: Predicted;
KW Antibiotic resistance {ECO:0000256|ARBA:ARBA00023251};
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741}.
FT DOMAIN 1..235
FT /note="Tr-type G"
FT /evidence="ECO:0000259|PROSITE:PS51722"
SQ SEQUENCE 646 AA; 73219 MW; 54CE2860050C4829 CRC64;
MYKTIGVLAH VDAGKTTFSE QLLYHTNSIQ ARGRVDHQDT FLDNHEIERA RGITIFAEQA
RMQVGNETYT LIDTPGHVDF SPEMERAIRV MDYAVLVVSA VEGVQGHTET VWQLLRQYHV
PTLFFINKID REGADVEAVK KQLQKEFSAD VLLINEPLRT DSISSQMKEW LAERDEQLLD
AFLAETLENH TCLTRLQTMI KEELAFPCFF GSALKDIGIK EFLMQLSLLT ETKYKKDEPF
QGEVFKIRHD GQQRLTFIKA LQGTLHVRDD FTFGEISEKV TEIRLYNGNR FETVQEVSAG
EVFAVKGLSQ ANIGDILGSA MCPQPFELVP TLQAKVQYVG QQHIKEILKI FRLLEAEEPS
LRVVWHEKFQ EIHVHIMGVI QLEVLSDVLK DRFALTVTFG EPQILYMETI ATVVTGYGHF
EPLKHYAEVH LRMEPTTRGA GNTFVNSCHA DDLSVGHQRL IEKHLFEREH HGLLTGFPVT
DIRFTLLTGS AHIKHTDGGD FREATFRALR QGLEQAENLL LEPYYRFKLK APNDFIGRMM
TDIQQAAGTF DAPIMTEEQV ILTGRAPVAT FMSYSTVFAA YTNGKGSLSL QFDGYDVCHN
TEEIIAQIAY DKNADPAYTS SSIFCAKGKG YSIPWHEAQA AMHCIK
//
