ID   R7ZWY4_9BACT            Unreviewed;      1071 AA.
AC   R7ZWY4;
DT   24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT   24-JUL-2013, sequence version 1.
DT   27-MAR-2024, entry version 46.
DE   RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE            EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
GN   ORFNames=ADIS_0839 {ECO:0000313|EMBL:EON78665.1};
OS   Lunatimonas lonarensis.
OC   Bacteria; Bacteroidota; Cytophagia; Cytophagales; Cyclobacteriaceae.
OX   NCBI_TaxID=1232681 {ECO:0000313|EMBL:EON78665.1, ECO:0000313|Proteomes:UP000013909};
RN   [1] {ECO:0000313|EMBL:EON78665.1, ECO:0000313|Proteomes:UP000013909}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AK24 {ECO:0000313|EMBL:EON78665.1,
RC   ECO:0000313|Proteomes:UP000013909};
RA   Singh A.;
RT   "A novel strain isolated from Lonar lake, Maharashtra, India.";
RL   Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC         Evidence={ECO:0000256|ARBA:ARBA00034618};
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EON78665.1}.
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DR   EMBL; AQHR01000025; EON78665.1; -; Genomic_DNA.
DR   RefSeq; WP_010852987.1; NZ_AQHR01000025.1.
DR   AlphaFoldDB; R7ZWY4; -.
DR   STRING; 1232681.ADIS_0839; -.
DR   PATRIC; fig|1288963.3.peg.838; -.
DR   OrthoDB; 9810135at2; -.
DR   Proteomes; UP000013909; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 3.
DR   Gene3D; 1.10.3170.10; Recbcd, chain B, domain 2; 1.
DR   InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR   InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR014016; UvrD-like_ATP-bd.
DR   PANTHER; PTHR11070:SF64; ATP-DEPENDENT DNA HELICASE REP; 1.
DR   PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR   Pfam; PF00580; UvrD-helicase; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR   PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE   4: Predicted;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW   ProRule:PRU00560};
KW   Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW   ProRule:PRU00560};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW   ProRule:PRU00560};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW   ProRule:PRU00560}; Reference proteome {ECO:0000313|Proteomes:UP000013909}.
FT   DOMAIN          1..463
FT                   /note="UvrD-like helicase ATP-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS51198"
FT   DOMAIN          494..750
FT                   /note="UvrD-like helicase C-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS51217"
FT   BINDING         11..18
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ   SEQUENCE   1071 AA;  123314 MW;  DB159505A4F9D86C CRC64;
     MLPSPFTIYK SSAGSGKTYT LTLEYLKLAL VHPLAFRQVL AVTFTNKATQ EMKERILMEL
     TRIKRNVDPS QTMDRELLLH LNISPEELMV RAAGTLSAIL HDYAAFSVST IDSFFQRIIR
     SFAREIDLQA KFELELDQEA VLDRLVERLI LSVSADPFLH RWLVNYSIEQ IQEGQVWDVR
     KNIKELGSQL FQESFKRYRF TIQSFLQQDE NLESIKRQVM DTRRKLVSEG VELRKQAQGI
     RERHGLSWQD FKGGNRTFAN KFEALGSPGN PFPTVSPSQI GLEDRPDDWY AKTSKLIPQI
     QAAFNEGLGT IWGRIKPLQR SWNTNEAIRK NLDVYGVFRF LLHELESLKE EENILLISDA
     NDFLREITAD NEAPFVYEKV GQKYRHYLID EFQDTSGFQW DSFRPLLIDS LSQGHANLLV
     GDVKQSIYRW RGGELRLLLE QVEAEIHQFG IQVKNLDINF RSLPQLVRFN NALFRRLPGQ
     LVGVLEQKFD ISDAGILAKA YQDVSQQVSP FKEKSPYQGL VRIEFLRSED SEDRFFDQAL
     SKIPEAIVRL QGQGYRPRDI AFLVRTKKEG VAIADQLISY GLANPGSPYS FDVVSDEALL
     VSRSSTVACV VSALRHLTEM DEEIHLKTMW YHWAVISGHS VSHALFENVS GISEVDEMKA
     RFCALQDSLL RLQLLDLIER IIEVLGLQDS GYERAYLEAF KDAIYEFVAT NRADLPGFLS
     WWDLQEKKRT IKIPDDHDAM RILTIHKSKG LQFKVVLMPF LDWRIFDTTK KPIVWTPYQM
     EGTLGEVILP LTMKVDLKDS DFREVYQEEA LMAHLDTLNL VYVAITRAEE VFWAFAPVSN
     LEKTMYGNLA PNLERVLREK SDLGAGVSLG DYFDTVEDVF QVGDWPPSKN PTGGAYRVFP
     VRWQSRKWED LLSVKATAAD FSEQNLKLRQ KGSFGTLVHG LLEKAQSTGE LNLRLEELYF
     QGFVNQEEME ALRTQLGRLL RLPLFSRWFS GEGEVLSERG ILLPDGSLKR PDRVIFYIDR
     AEVVDFKTGQ KREFHVPQVR EYMHLVRTLT SLPVRGYLCY LDDMEILEID Q
//