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Database: UniProt
Entry: R8VS51_9CLOT
LinkDB: R8VS51_9CLOT
Original site: R8VS51_9CLOT 
ID   R8VS51_9CLOT            Unreviewed;       434 AA.
AC   R8VS51;
DT   24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT   24-JUL-2013, sequence version 1.
DT   25-OCT-2017, entry version 33.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377};
GN   ORFNames=HMPREF1526_02775 {ECO:0000313|EMBL:EOQ35314.1};
OS   Butyricicoccus pullicaecorum 1.2.
OC   Bacteria; Firmicutes; Clostridia; Clostridiales; Clostridiaceae;
OC   Butyricicoccus.
OX   NCBI_TaxID=1203606 {ECO:0000313|EMBL:EOQ35314.1, ECO:0000313|Proteomes:UP000013981};
RN   [1] {ECO:0000313|EMBL:EOQ35314.1, ECO:0000313|Proteomes:UP000013981}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=1.2 {ECO:0000313|EMBL:EOQ35314.1,
RC   ECO:0000313|Proteomes:UP000013981};
RG   The Broad Institute Genome Sequencing Platform;
RA   Earl A., Ward D., Feldgarden M., Gevers D., Van Immerseel F.,
RA   Eeckhaut V., Walker B., Young S.K., Zeng Q., Gargeya S.,
RA   Fitzgerald M., Haas B., Abouelleil A., Alvarado L., Arachchi H.M.,
RA   Berlin A.M., Chapman S.B., Dewar J., Goldberg J., Griggs A., Gujja S.,
RA   Hansen M., Howarth C., Imamovic A., Larimer J., McCowan C., Murphy C.,
RA   Neiman D., Pearson M., Priest M., Roberts A., Saif S., Shea T.,
RA   Sisk P., Sykes S., Wortman J., Nusbaum C., Birren B.;
RT   "The Genome Sequence of Butyricicoccus pullicaecorum 1.2.";
RL   Submitted (JAN-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00735475}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS00911680}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:EOQ35314.1}.
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DR   EMBL; AQOB01000015; EOQ35314.1; -; Genomic_DNA.
DR   RefSeq; WP_016148868.1; NZ_KB976105.1.
DR   EnsemblBacteria; EOQ35314; EOQ35314; HMPREF1526_02775.
DR   PATRIC; fig|1203606.4.peg.2728; -.
DR   OrthoDB; POG091H02FF; -.
DR   Proteomes; UP000013981; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF2; PTHR30050:SF2; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00747950};
KW   Complete proteome {ECO:0000313|Proteomes:UP000013981};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS00911664};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00747996};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00911684};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00747895};
KW   Reference proteome {ECO:0000313|Proteomes:UP000013981}.
FT   DOMAIN      130    258       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      342    410       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     138    145       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   434 AA;  48687 MW;  DC416896E1582CB5 CRC64;
     MNSNNDLLKM ALSRMEGSFS PVTLSAWFDD AEAVSLEGTS FVLRAANQFK KEIIESRFTA
     PLQQALTELL GEPITLSVVY GDQVPSAEKT GESIGLSPDE EYTFEHFIVG SSNKFAHAAA
     VSVANHPAEN YNPLFIYGQS GLGKTHLLHA IGNVIRGTHP NFRIIYVKGE DFTNELVTAI
     QEGDVQSFRG KYRMADLLLI DDIQFIAGKE RTQEEFFHTF NALYEAGRQI VLTSDRPPKE
     MNTLEDRMKT RFEWGLLADI QPPDFETRVA IINAKAEKLG FDLPKDVIYC IAENLQSNVR
     QLEGTVKKIK AKHELGGEAI TIDMTQKVIE EVKSISPGLN PTPPMILQTV SNFYSVPVDQ
     ILSDRRSKDT VQPRQMAMYL VRKMTNYSLP EIGKVFGRDH TTVMHACDKI DGDRKKNAEL
     EDIIKTLIEN IQNL
//
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