ID R8W0F4_9CLOT Unreviewed; 3162 AA.
AC R8W0F4;
DT 24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2013, sequence version 1.
DT 27-MAR-2024, entry version 53.
DE RecName: Full=Helicase ATP-binding domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=HMPREF1526_01034 {ECO:0000313|EMBL:EOQ38006.1};
OS Butyricicoccus pullicaecorum 1.2.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Clostridiaceae;
OC Butyricicoccus.
OX NCBI_TaxID=1203606 {ECO:0000313|EMBL:EOQ38006.1, ECO:0000313|Proteomes:UP000013981};
RN [1] {ECO:0000313|EMBL:EOQ38006.1, ECO:0000313|Proteomes:UP000013981}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=1.2 {ECO:0000313|EMBL:EOQ38006.1,
RC ECO:0000313|Proteomes:UP000013981};
RG The Broad Institute Genome Sequencing Platform;
RA Earl A., Ward D., Feldgarden M., Gevers D., Van Immerseel F., Eeckhaut V.,
RA Walker B., Young S.K., Zeng Q., Gargeya S., Fitzgerald M., Haas B.,
RA Abouelleil A., Alvarado L., Arachchi H.M., Berlin A.M., Chapman S.B.,
RA Dewar J., Goldberg J., Griggs A., Gujja S., Hansen M., Howarth C.,
RA Imamovic A., Larimer J., McCowan C., Murphy C., Neiman D., Pearson M.,
RA Priest M., Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J.,
RA Nusbaum C., Birren B.;
RT "The Genome Sequence of Butyricicoccus pullicaecorum 1.2.";
RL Submitted (JAN-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EOQ38006.1}.
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DR EMBL; AQOB01000004; EOQ38006.1; -; Genomic_DNA.
DR PATRIC; fig|1203606.4.peg.992; -.
DR eggNOG; COG0249; Bacteria.
DR eggNOG; COG0553; Bacteria.
DR eggNOG; COG0827; Bacteria.
DR eggNOG; COG4646; Bacteria.
DR HOGENOM; CLU_000181_0_0_9; -.
DR Proteomes; UP000013981; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0140658; F:ATP-dependent chromatin remodeler activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR000330; SNF2_N.
DR PANTHER; PTHR41313; ADENINE-SPECIFIC METHYLTRANSFERASE; 1.
DR PANTHER; PTHR41313:SF1; DNA METHYLASE ADENINE-SPECIFIC DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF00176; SNF2-rel_dom; 1.
DR PRINTS; PR00507; N12N6MTFRASE.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF55271; DNA repair protein MutS, domain I; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022840};
KW Reference proteome {ECO:0000313|Proteomes:UP000013981}.
FT DOMAIN 2304..2553
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 2728..2890
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 252..369
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3121..3162
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 3064..3091
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 252..279
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 313..328
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3146..3162
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3162 AA; 356792 MW; 9799EFC8F9ED1B3A CRC64;
MPSKAEFYRQ MAEQVSTQLV GSWKEWTAFL TTAARLYKYP FHEQMMIYAQ RPDATACAEY
DLWNDKMGRY VRRGSKGIAL VDDSGDKPRL RYVFDISDTG TREHSRTPWL WQLEEQHIGP
VSAMLERSYG VAGDDLAQQL TDVAGKLASE YWDDHQRDFR YIVDGSFLAE YDDYNIEVQF
KSAATVSIAY ALMSRCGLDT EQYFQHEDFM PIFDFNTPAT VGALGAAVSQ INQQVLRQIG
VTIQNYEREQ LAERSVTHGE QPDLHDERRL SDSRPEADRT AGEAPGQVRQ DAESVPEGTP
SPDLQSAVAD REAVSAPHRD RRDSAEPSGA DDAPAGGSSG RNGAAESQRP DALGGPDEHL
QSTGRGDSDG GAYSQLSFFL SEAEQIRIID EAENVKTSSA FSFAQADIDH VLRLGGNTYR
QRERIVAAFE EQKSTAEIAD TLKNLYHGGN GIGSITAWYT EDGIHLSHGK TARYDKSAQV
ISWESAAERI SQLLQDGQFA TNMELAEAAG YERSLLAERF WELYHDFSEE AREAGYLPSL
ANNPGRGFPE ESAWLTEQLK SPEFRQNLAE EYAAFWTAYQ QDRDLLRFHY HKPKEIWENL
QDLSLPRTTF TSQLTEVPSV KQFISEDEID AAMTRGSGFE GGKGRVFTFF QEPHTDKEKV
DFLKHEYGIG GHSHALSGAM KSDESHDGKG LHYKKDGCPD VHFTWEKVAK RITDLIQKGR
YLTEQEQAEY DKIQAEKALA ESEPELEAVG RIEYLGTNGL PGESVEYTDA EKFIRTIQED
TDYGVPITVV LYRDTHGNTI PQDFLAELDP PPKGFRVEDA PAPMEELDQE QAEFDKSQEE
KVLADTDTME AQQPNPTVWE YNGVKERHPD DMVLYQMGDF FELYGEDAKT AATELDLNLT
LRAIPGGGYV EMCGFPANRL GQVVEQLRDK HDVTISAVPE GGRERQEYSM PSIDHEAEQH
INAQEAEFGA DGTRVFRDTE AAAAPTIREL HEQYKPIVLA AVMEDVPYRN ACGHSDYENA
VIEGNAAIRR AVLGSGNMEL LRLYSDTPEF RQRLHREIID ETYPKLHELL HPLTDNDIDK
AIQDWNGKIE SKHAVVRYME KHGREKDTAA WLAHEFDGGD GKTPFSVRPE SPEGTVLPWP
KVQRRIAQLI KEDRFYTEAE QDRFDNIDPI AIREALAERG IVNGELVDEE KLDNDPFIQR
VMADVEAISR ESVPADEPEQ PSPHNLRVLV SDEEYAAARG TLRERTSYDP AVPPYNVGDI
VYLDDRPHQI TELRDDTVQL LPTGMSYPIY RAESRERFEQ LLREDNRNDF YTEFLPANLD
TVDQDLRDVL AHGLIGEADK AELSELLRNG KSNQEVALWL SRAYPNIVET MELETGETAD
YRTMPEGIEL EVLDADEKRL AMLFFQWSEV APLLRGMYAR QLDGFEQERP EPAAETPAFQ
AETVAVYPGD KNNLPYDVVV QTLRTNEPEP PTPAVEPEKT LDEALDEHPV SIQVNGEWQT
FPNVKAAEEA SYEEYKANLR RTAENFRITD DHLGEGGPKA KFQANVEAIK LLKYLEETTE
QATPEQQKIL SRYVGWGGLA DAFDPDKESW SKEYAQLKEL LTPEEYAAAR GSTLNAHYTS
PTVIKAIYEA VGRMGFETGN ILEPSCGVGN FFGMLPEEMR NSRLYGVELD SISGRIAQQL
YPKADITVAG FETTDRRDFY DLAVGNVPFG QYQIRDKAYD KLNFSIHNYF FAKALDQVRP
GGVVAFVTSR YTMDAKDSTV RRYLAQRAEL LGAIRLPNDA FKKNAGAEVV SDIIFLQKRD
RPLDIVPEWT QTGQTEDGFA INRYFLDHPE MVLGRQEPES TAHGMDYTVN PIEGLELADQ
LHDAVKYIRG TYQEAELPEL GEGEAIDTSI PADPNVKNYS YTVVDGDVYY RENSRMVRPD
LNATAEARVK GLVGLRECVQ QLIDLQMDAA TPDSAIQDKQ AELNRLYDSF SAKYGLINDR
ANRLAFADDS SYYLLCALEV IDEDGKLERK ADMFTKRTIK PHKAVDAVDT ASEALAVSIS
EKACVDMAYM AELTGKTGDE LAAELQGVIF RVPGQVEKDG TPHYVTADEY LSGNVRRKLR
QAQRAAQQDP SFAINVEALT AAQPKDLDAS EIEVRLGATW IDKEYIQQFM YETFDTPFYL
QRNIEVNYSS FTAEWQITGK SSVSQNNVAA YTTYGTSRAN AYKILEDSLN LRDVRIYDTI
EDADGKERRV LNAKETTLAA QKQQAIRDAF KDWIWKDPDR RQALVRQYNE EMNSTRPREY
DGGHITFGGM NPAITLREHQ KNAIAHVLYG GNTLLAHEVG AGKTFEMVAA AMESKRLGLC
QKSLFVVPNH LTEQWASEFL RLYPSANILV TTKKDFETHN RKKFCARIAT GDYDAIIMGH
SQFEKIPISR ERQERLLQEQ IDEITEGIAE VKYSGGERFT VKQLERTKKS LEARLEKLQA
ESRKDDVVTF EQLGVDRLFV DEAHNYKNLF LYTKMRNVAG LSTSDAQKSS DMFAKCRYMD
ELTGNRGVIF ATGTPVSNSM TELYTMQRYL QYDRLQELNM THFDCWASRF GETVTALELA
PEGTGYRART RFSKFFNLPE LMNLFKEVAD IKTADQLNLP TPEVEYHNIV AQPTEHQKEM
VQVLSERASR VHSGSVDPSE DNMLKITGDG RKLGLDQRII NQLLPDEPGT KVNQCVGNIM
QIWRDGEADK LTQLVFCDIS TPQVQSASSK KAAKALDNPT LHALEQAVPL DEPEPAFTIY
EDIRQKLIAQ GMPAEQIAFI HEAKTEVQKK ELFSKVRTGQ VRVLLGSTSK MGAGTNVQDR
LVALHDLDCP WRPGDLAQRK GRIERQGNQN PLVHVYRYVT EGTFDSYLWQ TVENKQKFIS
QIMTSKSPVR SCDDVDETAL SFAEIKALCA GDPRIKERMD LDVEVARLKL MKADHQSKQY
RLEDQLLKYF PQEIETNKGF IKGFEADLET LAAHPHPEDG FAGMEIRGDV LTDKENAGAA
LLDACKEVKG SEPVQIGSYR GFTMSVEFSA WKQEYTLLLK GQMTHRASLG TDPRGNLTRI
DNALAQMPQR LEAVKNQLDN LYQQQAAAKE EIGKPFPFED DLRVKSARLV ELDTLLNIDG
KGRTQPETVV AKSARPSVLD SLKRPAPPRS PEKKPKQHEE VR
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