ID R8Y8H4_ACIPI Unreviewed; 416 AA.
AC R8Y8H4;
DT 24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2013, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE RecName: Full=RND efflux pump membrane fusion protein barrel-sandwich domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=F931_03568 {ECO:0000313|EMBL:EOQ65775.1};
OS Acinetobacter pittii ANC 4050.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Moraxellales; Moraxellaceae;
OC Acinetobacter; Acinetobacter calcoaceticus/baumannii complex.
OX NCBI_TaxID=1217691 {ECO:0000313|EMBL:EOQ65775.1, ECO:0000313|Proteomes:UP000014024};
RN [1] {ECO:0000313|EMBL:EOQ65775.1, ECO:0000313|Proteomes:UP000014024}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ANC 4050 {ECO:0000313|EMBL:EOQ65775.1,
RC ECO:0000313|Proteomes:UP000014024};
RG The Broad Institute Genome Sequencing Platform;
RG The Broad Institute Genome Sequencing Center for Infectious Disease;
RA Cerqueira G., Feldgarden M., Courvalin P., Perichon B.,
RA Grillot-Courvalin C., Clermont D., Rocha E., Yoon E.-J., Nemec A.,
RA Walker B., Young S.K., Zeng Q., Gargeya S., Fitzgerald M., Haas B.,
RA Abouelleil A., Alvarado L., Arachchi H.M., Berlin A.M., Chapman S.B.,
RA Dewar J., Goldberg J., Griggs A., Gujja S., Hansen M., Howarth C.,
RA Imamovic A., Larimer J., McCowan C., Murphy C., Neiman D., Pearson M.,
RA Priest M., Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J.,
RA Nusbaum C., Birren B.;
RT "The Genome Sequence of Acinetobacter sp. ANC 4050.";
RL Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane
CC {ECO:0000256|ARBA:ARBA00004519}; Lipid-anchor
CC {ECO:0000256|ARBA:ARBA00004519}. Membrane
CC {ECO:0000256|ARBA:ARBA00004635}; Lipid-anchor
CC {ECO:0000256|ARBA:ARBA00004635}.
CC -!- SIMILARITY: Belongs to the membrane fusion protein (MFP) (TC 8.A.1)
CC family. {ECO:0000256|ARBA:ARBA00009477}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EOQ65775.1}.
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DR EMBL; APQM01000012; EOQ65775.1; -; Genomic_DNA.
DR RefSeq; WP_016143195.1; NZ_KB976987.1.
DR AlphaFoldDB; R8Y8H4; -.
DR PATRIC; fig|1217691.3.peg.3497; -.
DR HOGENOM; CLU_018816_2_1_6; -.
DR OrthoDB; 9800613at2; -.
DR Proteomes; UP000014024; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0042221; P:response to chemical; IEA:UniProt.
DR Gene3D; 2.40.30.170; -; 1.
DR Gene3D; 2.40.420.20; -; 1.
DR Gene3D; 2.40.50.100; -; 1.
DR Gene3D; 1.10.287.470; Helix hairpin bin; 1.
DR InterPro; IPR043602; CusB_dom_1.
DR InterPro; IPR032317; HlyD_D23.
DR InterPro; IPR006143; RND_pump_MFP.
DR NCBIfam; TIGR01730; RND_mfp; 1.
DR PANTHER; PTHR30158; ACRA/E-RELATED COMPONENT OF DRUG EFFLUX TRANSPORTER; 1.
DR PANTHER; PTHR30158:SF3; MULTIDRUG EFFLUX PUMP SUBUNIT ACRA-RELATED; 1.
DR Pfam; PF00529; CusB_dom_1; 1.
DR Pfam; PF16576; HlyD_D23; 1.
DR SUPFAM; SSF111369; HlyD-like secretion proteins; 1.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Lipoprotein {ECO:0000256|ARBA:ARBA00023288};
KW Palmitate {ECO:0000256|ARBA:ARBA00023139};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 24..416
FT /note="RND efflux pump membrane fusion protein barrel-
FT sandwich domain-containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004479406"
FT DOMAIN 46..366
FT /note="Cation efflux system protein CusB"
FT /evidence="ECO:0000259|Pfam:PF00529"
FT DOMAIN 68..297
FT /note="RND efflux pump membrane fusion protein barrel-
FT sandwich"
FT /evidence="ECO:0000259|Pfam:PF16576"
FT REGION 376..416
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 111..169
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 382..416
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 416 AA; 43921 MW; 6D3F630B4742051A CRC64;
MMSAKLWAPA LTACALATSI ALVGCSKGSD EKQQAAAAQK MPPAEVGVIV AQPQSVEQSV
ELSGRTSAYQ ISEVRPQTSG VILKRLFAEG SYVREGQALY ELDSRTNRAT LENAKAALLQ
QQANLASLRT KLNRYKQLVS SNAVSRQEYD DLLGQVNVAE AQVSAAKAQV TNANVDLGYS
TIRSPISGQS GRSSVTAGAL VTANQTDPLV TIQQLDPIYV DINQSSAELL RLRQQLSKGS
LNNSNNTKVK LKLEDGSTYP IEGQLAFSDA SVNQDTGTIT LRAVFSNPNH LLLPGMYTTA
QIVQGVVPNA YLIPQAAITR LPTGQAVAML VNAKGTVESR PVETSGVQGQ NWIVTNGLKV
GDKVIVDGVA KVKEGQEVSA KPYQAQPANP QGAAPNATKP AQSGKPQAEQ KASSNA
//
