ID R9APG6_WALI9 Unreviewed; 640 AA.
AC R9APG6;
DT 24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2013, sequence version 1.
DT 27-MAR-2024, entry version 44.
DE SubName: Full=tRNA pseudouridine synthase 1 {ECO:0000313|EMBL:EOR03930.1};
GN ORFNames=J056_002008 {ECO:0000313|EMBL:EOR03930.1};
OS Wallemia ichthyophaga (strain EXF-994 / CBS 113033).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Wallemiomycotina;
OC Wallemiomycetes; Wallemiales; Wallemiaceae; Wallemia.
OX NCBI_TaxID=1299270 {ECO:0000313|EMBL:EOR03930.1, ECO:0000313|Proteomes:UP000014064};
RN [1] {ECO:0000313|Proteomes:UP000014064}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=EXF-994 / CBS 113033 {ECO:0000313|Proteomes:UP000014064};
RX PubMed=24034603; DOI=10.1186/1471-2164-14-617;
RA Zajc J., Liu Y., Dai W., Yang Z., Hu J., Gostincar C., Gunde-Cimerman N.;
RT "Genome and transcriptome sequencing of the halophilic fungus Wallemia
RT ichthyophaga: haloadaptations present and absent.";
RL BMC Genomics 14:617-617(2013).
CC -!- SIMILARITY: Belongs to the tRNA pseudouridine synthase TruA family.
CC {ECO:0000256|ARBA:ARBA00009375}.
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DR EMBL; KE007225; EOR03930.1; -; Genomic_DNA.
DR RefSeq; XP_009266147.1; XM_009267872.1.
DR AlphaFoldDB; R9APG6; -.
DR STRING; 1299270.R9APG6; -.
DR GeneID; 20374960; -.
DR KEGG; wic:J056_002008; -.
DR eggNOG; KOG2553; Eukaryota.
DR HOGENOM; CLU_021971_0_2_1; -.
DR OMA; NKAFDCR; -.
DR OrthoDB; 12038at2759; -.
DR Proteomes; UP000014064; Unassembled WGS sequence.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; IEA:UniProt.
DR GO; GO:0009982; F:pseudouridine synthase activity; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0031119; P:tRNA pseudouridine synthesis; IEA:InterPro.
DR CDD; cd02568; PseudoU_synth_PUS1_PUS2; 1.
DR Gene3D; 3.30.70.660; Pseudouridine synthase I, catalytic domain, C-terminal subdomain; 1.
DR Gene3D; 3.30.70.580; Pseudouridine synthase I, catalytic domain, N-terminal subdomain; 1.
DR InterPro; IPR020103; PsdUridine_synth_cat_dom_sf.
DR InterPro; IPR001406; PsdUridine_synth_TruA.
DR InterPro; IPR020097; PsdUridine_synth_TruA_a/b_dom.
DR InterPro; IPR020095; PsdUridine_synth_TruA_C.
DR InterPro; IPR041708; PUS1/PUS2-like.
DR InterPro; IPR020094; TruA/RsuA/RluB/E/F_N.
DR NCBIfam; TIGR00071; hisT_truA; 1.
DR PANTHER; PTHR11142; PSEUDOURIDYLATE SYNTHASE; 1.
DR PANTHER; PTHR11142:SF4; PSEUDOURIDYLATE SYNTHASE 1 HOMOLOG; 1.
DR Pfam; PF01416; PseudoU_synth_1; 1.
DR SUPFAM; SSF55120; Pseudouridine synthase; 1.
PE 3: Inferred from homology;
KW Isomerase {ECO:0000256|ARBA:ARBA00023235};
KW Reference proteome {ECO:0000313|Proteomes:UP000014064};
KW tRNA processing {ECO:0000256|ARBA:ARBA00022694}.
FT DOMAIN 348..447
FT /note="Pseudouridine synthase I TruA alpha/beta"
FT /evidence="ECO:0000259|Pfam:PF01416"
FT REGION 93..158
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 477..514
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 592..640
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 128..142
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 477..509
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 614..640
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 224
FT /note="Nucleophile"
FT /evidence="ECO:0000256|PIRSR:PIRSR641708-1"
FT BINDING 283
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR641708-2"
SQ SEQUENCE 640 AA; 71774 MW; 10A852C7EF802E81 CRC64;
MALASYILGF SGVGFATRCW QLAIERRNVF DNFFGHLIAV GAFGTAGFFL HGVSQRQQNA
LEDRKQVLIE NRQKNSQRLL VGMSDTLNTL KRQGSEGAEG VAEAATAAAT ATPTRPAQKK
QKKQKPNKRE KKPDERKTWT KDWAGLPKLS DITPSDTPKL PKRKCAVIVG FCGTGYNGMQ
IQPHANTRTI EGEIFLAMVN AGVISRENST DPGKVNLQRA ARTDASVHAA SNVISLKMIV
ELPEQGDPVA AINSHLPPHI RIWGYVRTQN SFDARNSCDS RRYEYLLPSY VFLPPAPWTN
LGKRLGTQHP FWSEEGVDEN ESVEGMMQRK RAWRIDTDTL SKARATLQHF TGSHNFWSYT
IGKAFTERSA QRYMKELEIR EPFLVEGNEW ISVRFYGQSF MLHQIRKMIF MLVNVTRTPT
PPSLIEKTYS NTPIVVPKAP GLGLLLEAPC FGVYNTRVQE NNIAVEKSAE DRVKKAIEKA
HKEQSKVGEK QGENGNEIEK KEKDQEQQGT TLTDEQIRHD TLKQLDGDKK EVIDFEQYSA
QIDAFKHEHI YTRLRAEEVT GNVYSRWTGM IDTHEGEQLD YLNGDGVIPD SAVKSGRKGM
KGGQSASLDG ADVKPIKQLD DSDNEESYDK KALKSGELEG
//