ID R9ARL0_WALI9 Unreviewed; 237 AA.
AC R9ARL0;
DT 24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2013, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE RecName: Full=D-lactate dehydratase {ECO:0000256|ARBA:ARBA00013134};
DE EC=4.2.1.130 {ECO:0000256|ARBA:ARBA00013134};
GN ORFNames=J056_000212 {ECO:0000313|EMBL:EOR04862.1};
OS Wallemia ichthyophaga (strain EXF-994 / CBS 113033).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Wallemiomycotina;
OC Wallemiomycetes; Wallemiales; Wallemiaceae; Wallemia.
OX NCBI_TaxID=1299270 {ECO:0000313|EMBL:EOR04862.1, ECO:0000313|Proteomes:UP000014064};
RN [1] {ECO:0000313|Proteomes:UP000014064}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=EXF-994 / CBS 113033 {ECO:0000313|Proteomes:UP000014064};
RX PubMed=24034603; DOI=10.1186/1471-2164-14-617;
RA Zajc J., Liu Y., Dai W., Yang Z., Hu J., Gostincar C., Gunde-Cimerman N.;
RT "Genome and transcriptome sequencing of the halophilic fungus Wallemia
RT ichthyophaga: haloadaptations present and absent.";
RL BMC Genomics 14:617-617(2013).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + methylglyoxal = (R)-lactate + H(+);
CC Xref=Rhea:RHEA:27754, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:16004, ChEBI:CHEBI:17158; EC=4.2.1.130;
CC Evidence={ECO:0000256|ARBA:ARBA00001524};
CC -!- SIMILARITY: Belongs to the peptidase C56 family. HSP31-like subfamily.
CC {ECO:0000256|ARBA:ARBA00038493}.
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DR EMBL; KE007224; EOR04862.1; -; Genomic_DNA.
DR RefSeq; XP_009265885.1; XM_009267610.1.
DR AlphaFoldDB; R9ARL0; -.
DR STRING; 1299270.R9ARL0; -.
DR GeneID; 20373164; -.
DR KEGG; wic:J056_000212; -.
DR eggNOG; ENOG502RZ3Y; Eukaryota.
DR HOGENOM; CLU_070319_2_0_1; -.
DR OMA; GEKTGFW; -.
DR OrthoDB; 2049468at2759; -.
DR Proteomes; UP000014064; Unassembled WGS sequence.
DR GO; GO:0019172; F:glyoxalase III activity; IEA:UniProt.
DR CDD; cd03141; GATase1_Hsp31_like; 1.
DR Gene3D; 3.40.50.880; -; 1.
DR InterPro; IPR029062; Class_I_gatase-like.
DR InterPro; IPR002818; DJ-1/PfpI.
DR PANTHER; PTHR48094:SF11; GLUTATHIONE-INDEPENDENT GLYOXALASE HSP31-RELATED; 1.
DR PANTHER; PTHR48094; PROTEIN/NUCLEIC ACID DEGLYCASE DJ-1-RELATED; 1.
DR Pfam; PF01965; DJ-1_PfpI; 1.
DR SUPFAM; SSF52317; Class I glutamine amidotransferase-like; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000014064};
KW Stress response {ECO:0000256|ARBA:ARBA00023016}.
FT DOMAIN 80..227
FT /note="DJ-1/PfpI"
FT /evidence="ECO:0000259|Pfam:PF01965"
SQ SEQUENCE 237 AA; 25569 MW; 681C40C72320A0A2 CRC64;
MSSAVTLPKV LIVLSSATKT LKGEDTGVFI SELAHPFYAI HQHVDITFAS PTGHSVIDPG
SIAMFKDDIE SMSFLKDRAD KYQNNVPLSQ INPAEYDAVF LPGGHGPSID LIKDNDAQRV
ISRIYQAGKP VAAVCHAGGV LGNVVDKHSE SIYKGRQATA FSNTEEEMVG KVQSISETPE
DHIKRHGGVY VKADQPWGEC VIVDKNANGV YISGQNPASA KKLGDEFLKA IHEGVQK
//
