ID   R9AU85_WALI9            Unreviewed;       839 AA.
AC   R9AU85;
DT   24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT   24-JUL-2013, sequence version 1.
DT   08-NOV-2023, entry version 47.
DE   SubName: Full=DNA mismatch repair protein pms1 {ECO:0000313|EMBL:EOR03661.1};
GN   ORFNames=J056_003118 {ECO:0000313|EMBL:EOR03661.1};
OS   Wallemia ichthyophaga (strain EXF-994 / CBS 113033).
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Wallemiomycotina;
OC   Wallemiomycetes; Wallemiales; Wallemiaceae; Wallemia.
OX   NCBI_TaxID=1299270 {ECO:0000313|EMBL:EOR03661.1, ECO:0000313|Proteomes:UP000014064};
RN   [1] {ECO:0000313|Proteomes:UP000014064}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=EXF-994 / CBS 113033 {ECO:0000313|Proteomes:UP000014064};
RX   PubMed=24034603; DOI=10.1186/1471-2164-14-617;
RA   Zajc J., Liu Y., Dai W., Yang Z., Hu J., Gostincar C., Gunde-Cimerman N.;
RT   "Genome and transcriptome sequencing of the halophilic fungus Wallemia
RT   ichthyophaga: haloadaptations present and absent.";
RL   BMC Genomics 14:617-617(2013).
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC       {ECO:0000256|ARBA:ARBA00006082}.
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DR   EMBL; KE007226; EOR03661.1; -; Genomic_DNA.
DR   RefSeq; XP_009266697.1; XM_009268422.1.
DR   AlphaFoldDB; R9AU85; -.
DR   STRING; 1299270.R9AU85; -.
DR   GeneID; 20376070; -.
DR   KEGG; wic:J056_003118; -.
DR   eggNOG; KOG1978; Eukaryota.
DR   HOGENOM; CLU_004131_0_2_1; -.
DR   OMA; RCSKIRS; -.
DR   OrthoDB; 4698638at2759; -.
DR   Proteomes; UP000014064; Unassembled WGS sequence.
DR   GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0061982; P:meiosis I cell cycle process; IEA:UniProt.
DR   GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR   CDD; cd03484; MutL_Trans_hPMS_2_like; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR   Gene3D; 3.30.1540.20; MutL, C-terminal domain, dimerisation subdomain; 1.
DR   Gene3D; 3.30.1370.100; MutL, C-terminal domain, regulatory subdomain; 1.
DR   InterPro; IPR014762; DNA_mismatch_repair_CS.
DR   InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR002099; MutL/Mlh/PMS.
DR   InterPro; IPR038973; MutL/Mlh/Pms-like.
DR   InterPro; IPR014790; MutL_C.
DR   InterPro; IPR042120; MutL_C_dimsub.
DR   InterPro; IPR042121; MutL_C_regsub.
DR   InterPro; IPR037198; MutL_C_sf.
DR   InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR   InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR   NCBIfam; TIGR00585; mutl; 1.
DR   PANTHER; PTHR10073; DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL; 1.
DR   PANTHER; PTHR10073:SF52; MISMATCH REPAIR ENDONUCLEASE PMS2; 1.
DR   Pfam; PF01119; DNA_mis_repair; 1.
DR   Pfam; PF13589; HATPase_c_3; 1.
DR   Pfam; PF08676; MutL_C; 1.
DR   SMART; SM01340; DNA_mis_repair; 1.
DR   SMART; SM00853; MutL_C; 1.
DR   SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR   SUPFAM; SSF118116; DNA mismatch repair protein MutL; 1.
DR   SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
DR   PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE   3: Inferred from homology;
KW   DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW   Reference proteome {ECO:0000313|Proteomes:UP000014064}.
FT   DOMAIN          220..357
FT                   /note="DNA mismatch repair protein S5"
FT                   /evidence="ECO:0000259|SMART:SM01340"
FT   DOMAIN          630..784
FT                   /note="MutL C-terminal dimerisation"
FT                   /evidence="ECO:0000259|SMART:SM00853"
FT   REGION          385..461
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        398..427
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        428..442
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   839 AA;  94815 MW;  1A48E09B6990E8E1 CRC64;
     MSLNSIDTKT KNKLQSDQVI LDLQSAVKEL IENSLDANSS IIEINFYNSG FDGFKVIDNG
     FGIHESSFSS LTKKHFTSKL SNFDDLNNLC TFGFRGEALS SLSTISKSFD CLTATDVTSP
     KATNISFDNK GNITQLRHNI PRQRGTTISL STLFYNLPVR RREFEKNLKR EFSKAINLLQ
     SYALCPLHSS VKFNISNYNK ANKKSIIFQT AGKSSLPSSI ASVFGSTANQ SLVPLSLELP
     VQVDPSIAKR EGITNTSFTV NLIGSISKPL FAHGRSTSDR QYFYINGRPC NLPKVAKTIN
     SLFRSYINQS YPFIVADFKI PTDAYDVNIT PDKRTIFLHF ESSLIDSLNY HLNLFFEPFR
     GHFTINKQSQ SVPTPIIHQP SIQMHSIPLN EPPNKLSDLP QKDADDDQHS YDRDAESLSE
     EQISQDDFQK KPNNNSIDSD NDGSVVCEKV NDLPENPMSS SQINTRHASW ASEVFPDNQV
     TVDRAPKRRK TETELIDEIS DRETDTKIRI DQTDSKVFDN GFYNQIDEND VQNPHNIDMQ
     IVNDTFTIDE SSEDDEPNYF RQSLTVNIDE LHYKWQKDTN KSNALTNENS QKLYSEKLEK
     AGIENFDNSQ AAEQALSRVL HKTDFENLEI LGQFNLGFMI VKRKAVNDNG LQENDLFIVD
     QHAADEKYNY EKLQLNSRIQ SQKLIKPRTL DLSASDELTV FDNLETLKQN GFEIQVDGDG
     ASGRRCQLVA LPLSKTTVFD LRVDLEELIH DINENPSQVP RCTKAKDMFA SRACRMSVMV
     GKSLKKKQMT SIVRNLSTLK QPWVSIFKLL SLIKLLICVE LSSWEANAAA PTKLREQAG
//