ID   R9H672_BACT4            Unreviewed;       815 AA.
AC   R9H672;
DT   24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT   24-JUL-2013, sequence version 1.
DT   24-JAN-2024, entry version 30.
DE   RecName: Full=beta-N-acetylhexosaminidase {ECO:0000256|ARBA:ARBA00012663};
DE            EC=3.2.1.52 {ECO:0000256|ARBA:ARBA00012663};
GN   ORFNames=C799_03449 {ECO:0000313|EMBL:EOR99567.1};
OS   Bacteroides thetaiotaomicron dnLKV9.
OC   Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Bacteroidaceae;
OC   Bacteroides.
OX   NCBI_TaxID=1235785 {ECO:0000313|EMBL:EOR99567.1, ECO:0000313|Proteomes:UP000014207};
RN   [1] {ECO:0000313|EMBL:EOR99567.1, ECO:0000313|Proteomes:UP000014207}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=dnLKV9 {ECO:0000313|Proteomes:UP000014207};
RG   The Broad Institute Genomics Platform;
RG   The Broad Institute Genome Sequencing Center for Infectious Disease;
RA   Earl A., Xavier R., Kuhn K., Stappenbeck T., Walker B., Young S., Zeng Q.,
RA   Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA   Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA   Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA   Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA   Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA   Birren B.;
RT   "The Genome Sequence of Bacteroides thetaiotaomicron dnLKV9.";
RL   Submitted (APR-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the glycosyl hydrolase 20 family.
CC       {ECO:0000256|ARBA:ARBA00006285}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EOR99567.1}.
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DR   EMBL; ASSM01000010; EOR99567.1; -; Genomic_DNA.
DR   RefSeq; WP_016269108.1; NZ_KE159460.1.
DR   AlphaFoldDB; R9H672; -.
DR   PATRIC; fig|1235785.3.peg.3481; -.
DR   HOGENOM; CLU_007082_5_0_10; -.
DR   Proteomes; UP000014207; Unassembled WGS sequence.
DR   GO; GO:0004563; F:beta-N-acetylhexosaminidase activity; IEA:UniProtKB-EC.
DR   GO; GO:0102148; F:N-acetyl-beta-D-galactosaminidase activity; IEA:UniProtKB-EC.
DR   GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR   CDD; cd06563; GH20_chitobiase-like; 1.
DR   Gene3D; 3.30.379.10; Chitobiase/beta-hexosaminidase domain 2-like; 1.
DR   Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR   Gene3D; 3.20.20.80; Glycosidases; 1.
DR   InterPro; IPR025705; Beta_hexosaminidase_sua/sub.
DR   InterPro; IPR026876; Fn3_assoc_repeat.
DR   InterPro; IPR015883; Glyco_hydro_20_cat.
DR   InterPro; IPR017853; Glycoside_hydrolase_SF.
DR   InterPro; IPR029018; Hex-like_dom2.
DR   InterPro; IPR015882; HEX_bac_N.
DR   PANTHER; PTHR22600; BETA-HEXOSAMINIDASE; 1.
DR   PANTHER; PTHR22600:SF21; BETA-HEXOSAMINIDASE A; 1.
DR   Pfam; PF13287; Fn3_assoc; 1.
DR   Pfam; PF00728; Glyco_hydro_20; 1.
DR   Pfam; PF02838; Glyco_hydro_20b; 1.
DR   PRINTS; PR00738; GLHYDRLASE20.
DR   SUPFAM; SSF51445; (Trans)glycosidases; 1.
DR   SUPFAM; SSF55545; beta-N-acetylhexosaminidase-like domain; 1.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801}.
FT   DOMAIN          41..162
FT                   /note="Beta-hexosaminidase bacterial type N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF02838"
FT   DOMAIN          202..540
FT                   /note="Glycoside hydrolase family 20 catalytic"
FT                   /evidence="ECO:0000259|Pfam:PF00728"
FT   ACT_SITE        364
FT                   /note="Proton donor"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR625705-1"
SQ   SEQUENCE   815 AA;  91533 MW;  DB86E1F57123CAD6 CRC64;
     MDGFGVPCFI GFARKSLRVW WMWSFLSFFM ASAAGAVSYR DLIPEPVSVV DKKGDPFVVN
     DRTKIVYPQD HVQWKRTAEF LAGYVEGMTG YRLPVEECRS SESEPVISSE DNVIRFQCDS
     RMRKDGFKLS VGKYGVVIQA ADGAGVFYAV QLLRQLLLSG AEQIQTERTQ KEQIQTQQTI
     AASSAKTLNI PPVELEDYPS LSYRGAMLDV SRHFFSVAQI KRVIDLLAFH RLNHFHWHLT
     DDQGWRIEIK KYPDLTKIGA WRGEDKYGGF YTQEEIKEVV AYAAERYITV IPEIDMPGHT
     QAALAAYPQL GCVGSSYEVA TEVGGVHKDV MCVGNDFTLP FVKDVLKEIA ALFPASFIHI
     GGDEVPKERW SQCDACQKAI RDKGLKDTDK HTAEEYLQST FNEEIADYLR SIGKRMIGWD
     EVLSDSLSRD ITIMSWRGLG RATTAARKGH SVIVSADSHL YLNHYQTINS EQEPRATGGL
     VEMKKVYETP FFSPELTAQE KERILGVQAC LWTSFIDSDQ LLDYMLLPRL AAFAEAAWCE
     ERRGTYARFL HRLPAILNCY GQLGYGYAPH FFTISAAYKT VSTLVHEDSF DDKCLEISME
     SLPDTEIYYT LDGSKPSKSS SLYTAPLQVE ESCTLKAVSY LPNGLSSDEL TKEVVVNKAT
     FRPVQLLNPP SERYRGEDGK VLVDGIRSIN FHNTGLWVGY YTTDLVAVID LASFQHVSSV
     EVSALTDLSA WIMGPQSISV FVSLDGEKYE MVSRQTYQAP TDAMGEKRSD LNRLSFDSVP
     ARYIKVVAEP FKGLPKGHSG EGEPPFLFVD EIRVN
//