ID R9HSB1_BACUN Unreviewed; 617 AA.
AC R9HSB1;
DT 24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2013, sequence version 1.
DT 24-JAN-2024, entry version 26.
DE SubName: Full=Precorrin-4 C11-methyltransferase {ECO:0000313|EMBL:EOS06907.1};
GN ORFNames=C801_02678 {ECO:0000313|EMBL:EOS06907.1};
OS Bacteroides uniformis dnLKV2.
OC Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Bacteroidaceae;
OC Bacteroides.
OX NCBI_TaxID=1235787 {ECO:0000313|EMBL:EOS06907.1, ECO:0000313|Proteomes:UP000014212};
RN [1] {ECO:0000313|EMBL:EOS06907.1, ECO:0000313|Proteomes:UP000014212}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=dnLKV2 {ECO:0000313|Proteomes:UP000014212};
RG The Broad Institute Genomics Platform;
RG The Broad Institute Genome Sequencing Center for Infectious Disease;
RA Earl A., Xavier R., Kuhn K., Stappenbeck T., Walker B., Young S., Zeng Q.,
RA Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Bacteroides uniformis dnLKV2.";
RL Submitted (APR-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EOS06907.1}.
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DR EMBL; ASSO01000009; EOS06907.1; -; Genomic_DNA.
DR RefSeq; WP_016273635.1; NZ_KE159487.1.
DR AlphaFoldDB; R9HSB1; -.
DR PATRIC; fig|1235787.3.peg.2725; -.
DR HOGENOM; CLU_028397_1_0_10; -.
DR Proteomes; UP000014212; Unassembled WGS sequence.
DR GO; GO:0046026; F:precorrin-4 C11-methyltransferase activity; IEA:InterPro.
DR GO; GO:0009236; P:cobalamin biosynthetic process; IEA:InterPro.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR CDD; cd11641; Precorrin-4_C11-MT; 1.
DR Gene3D; 3.40.50.11220; -; 1.
DR Gene3D; 3.30.420.180; CobE/GbiG C-terminal domain; 1.
DR InterPro; IPR000878; 4pyrrol_Mease.
DR InterPro; IPR035996; 4pyrrol_Methylase_sf.
DR InterPro; IPR014777; 4pyrrole_Mease_sub1.
DR InterPro; IPR014776; 4pyrrole_Mease_sub2.
DR InterPro; IPR021745; CbiG_mid.
DR InterPro; IPR021744; CbiG_N.
DR InterPro; IPR006362; Cbl_synth_CobM/CibF.
DR InterPro; IPR002750; CobE/GbiG_C.
DR InterPro; IPR036518; CobE/GbiG_C_sf.
DR InterPro; IPR038029; GbiG_N_sf.
DR NCBIfam; TIGR01465; cobM_cbiF; 1.
DR PANTHER; PTHR37477; COBALT-PRECORRIN-5A HYDROLASE; 1.
DR PANTHER; PTHR37477:SF1; COBALT-PRECORRIN-5A HYDROLASE; 1.
DR Pfam; PF01890; CbiG_C; 1.
DR Pfam; PF11761; CbiG_mid; 1.
DR Pfam; PF11760; CbiG_N; 1.
DR Pfam; PF00590; TP_methylase; 1.
DR SUPFAM; SSF159672; CbiG N-terminal domain-like; 1.
DR SUPFAM; SSF159664; CobE/GbiG C-terminal domain-like; 1.
DR SUPFAM; SSF53790; Tetrapyrrole methylase; 1.
PE 4: Predicted;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW ECO:0000313|EMBL:EOS06907.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000014212};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:EOS06907.1}.
FT DOMAIN 46..126
FT /note="Cobalamin synthesis G N-terminal"
FT /evidence="ECO:0000259|Pfam:PF11760"
FT DOMAIN 131..242
FT /note="Cobalamin biosynthesis central region"
FT /evidence="ECO:0000259|Pfam:PF11761"
FT DOMAIN 246..361
FT /note="CobE/GbiG C-terminal"
FT /evidence="ECO:0000259|Pfam:PF01890"
FT DOMAIN 374..577
FT /note="Tetrapyrrole methylase"
FT /evidence="ECO:0000259|Pfam:PF00590"
SQ SEQUENCE 617 AA; 68258 MW; 209A138B0B4A32F5 CRC64;
MKTAIILISE AGLSIAQSLL NELPDSEIFT LRHEEGCTHI ESAGKFTAEN FNRYDAFVFI
GAMGICVRTI APCVKNKYTD PAVVCVDSTG KFAISVLSGH IGGANELTHQ VANILGAEPV
VTTQSDCTGL WGLDTLPQRF GWFPVINAEP STLLLAELAK TPEEKKRVCM NEHISLFVSG
KPTALLLTVR NEGTDWMEAH LPPHVEVFYR VQDIKPSRFK LILCVSPQVP NFPEMPMICY
VPCVVHLGIG LARLAGPVRK VEKEIMNTLK EYGIMPQSIA SISTIKAKSD EPVVKALQKK
FPVYFYTAEE LVEIEVPHPS KTVMKHMGTP SVSEAAALLS ANNSRLLVPK KKGENYTVAA
ALDIRTVRQG HIEIVGAGPG DPDLVSVRGR QMLERADLIL YAGSLVPKEL TLCAKAGATV
LSSASMDLEE QFEVMKKFYD KGKFIVRLHT GDPCIYGAIQ EQMNYFDQHG MSYHITPGIS
SFQAAAAALK SQFTIPEKVQ SIILTRGEGR TPMPEREKLH LMARSQSTMC IFLSASIAEQ
VQEELLQEYP ETTPVAVCYH LTWKDEQIFR GELKDLARIV KENNLTLTTM IVVGEAIGNR
EGLSRLYAHE FKHLYRK
//
