ID R9IIV2_9FIRM Unreviewed; 758 AA.
AC R9IIV2;
DT 24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2013, sequence version 1.
DT 24-JAN-2024, entry version 34.
DE RecName: Full=Metallo-beta-lactamase domain-containing protein {ECO:0000259|SMART:SM00849};
GN ORFNames=C804_05935 {ECO:0000313|EMBL:EOS21713.1};
OS Lachnospiraceae bacterium A4.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae.
OX NCBI_TaxID=397291 {ECO:0000313|EMBL:EOS21713.1, ECO:0000313|Proteomes:UP000014118};
RN [1] {ECO:0000313|EMBL:EOS21713.1, ECO:0000313|Proteomes:UP000014118}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=A4 {ECO:0000313|EMBL:EOS21713.1,
RC ECO:0000313|Proteomes:UP000014118};
RG The Broad Institute Genomics Platform;
RG The Broad Institute Genome Sequencing Center for Infectious Disease;
RA Earl A., Xavier R., Elson C., Duck W., Walker B., Young S., Zeng Q.,
RA Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Lachnospiraceae bacterium A4.";
RL Submitted (APR-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EOS21713.1}.
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DR EMBL; ASSR01000144; EOS21713.1; -; Genomic_DNA.
DR AlphaFoldDB; R9IIV2; -.
DR STRING; 397291.C804_05935; -.
DR PATRIC; fig|397291.3.peg.6167; -.
DR eggNOG; COG0658; Bacteria.
DR eggNOG; COG2333; Bacteria.
DR HOGENOM; CLU_010363_2_2_9; -.
DR OrthoDB; 9761531at2; -.
DR Proteomes; UP000014118; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR CDD; cd07731; ComA-like_MBL-fold; 1.
DR Gene3D; 3.60.15.10; Ribonuclease Z/Hydroxyacylglutathione hydrolase-like; 1.
DR InterPro; IPR035681; ComA-like_MBL.
DR InterPro; IPR004477; ComEC_N.
DR InterPro; IPR025405; DUF4131.
DR InterPro; IPR001279; Metallo-B-lactamas.
DR InterPro; IPR036866; RibonucZ/Hydroxyglut_hydro.
DR NCBIfam; TIGR00360; ComEC_N-term; 1.
DR PANTHER; PTHR30619; DNA INTERNALIZATION/COMPETENCE PROTEIN COMEC/REC2; 1.
DR PANTHER; PTHR30619:SF1; RECOMBINATION PROTEIN 2; 1.
DR Pfam; PF03772; Competence; 1.
DR Pfam; PF13567; DUF4131; 1.
DR Pfam; PF00753; Lactamase_B; 1.
DR SMART; SM00849; Lactamase_B; 1.
DR SUPFAM; SSF56281; Metallo-hydrolase/oxidoreductase; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000014118};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 191..210
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 217..235
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 265..280
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 286..307
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 319..338
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 350..379
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 386..404
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 416..440
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 498..707
FT /note="Metallo-beta-lactamase"
FT /evidence="ECO:0000259|SMART:SM00849"
SQ SEQUENCE 758 AA; 83215 MW; B448349BE849A3B0 CRC64;
MRRPLCCVCA AFVVTVFLYL QINPAPVPKL CLEEGSIVTL QGRVVQKYTQ EETLVLQLDC
VSMVHPKQKI DGRVLCYIEQ KECSIVPKAG SIIAVEGKVS GFSRARNPGE FDAQGYYQLQ
GVAFRLYRAE VIAQGSGYSA YREYLYQIRH FFEEIFDSVL SPKDASIMKA ILLGSKSGLD
EESKQLFQKS GIAHIFAISG LHITMLGMGL YHILRKLWIP QPLCAVVSVG VMVAYGDLAG
MSSSAYRAVV MFGLQLAAQM LRRTYDMLTA LALAAVLILM EEPRYLYYSG FQLSFGAILG
IGCLSELIKP VRWKVLEPLC ASLRIFLVHF PIMLSVYYEF PVYSFLLNLV IIPAMSVLMA
AGLVCLAAGS LPAVFGFWLA KLAGGVCHLL LACFEGLCVL SLRLPFANWV VGKPDLWRSC
AFCAVVVFLY AAHQYGAFLS KRLPREGLYH ARGALYGQKE LAVGLPALVK FVAVLSAVLL
LSDNPADGVS MTFLDVGQGD CIWIESAAGE QFLVDGGSSS KSRTGRYTIV PFLKYNGVSV
LEAVFLTHLD SDHISGIMEM LEGSGQALEI KIKRLCISDA VIEDEPYHEL KALCERRQIP
IYRLKAGDSM EACGLRFEVL HPHAGYEAAS RNSSSLVMKL EAEGVTALLT GDVEADGEQA
AAGRLLQQND AAGIDIYKAA HHGSKYSNTQ ALLSQLQPET AIISCGENNR YGHPHTETVE
RLEQTGSDIW ITKDTGAITI HIRKGSYTIE PFLKNDQK
//
