ID   R9JGU5_9FIRM            Unreviewed;       510 AA.
AC   R9JGU5;
DT   24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT   24-JUL-2013, sequence version 1.
DT   24-JAN-2024, entry version 32.
DE   RecName: Full=GH25 family lysozyme M1 (1,4-beta-N-acetylmuramidase) {ECO:0008006|Google:ProtNLM};
GN   ORFNames=C804_02405 {ECO:0000313|EMBL:EOS33216.1};
OS   Lachnospiraceae bacterium A4.
OC   Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae.
OX   NCBI_TaxID=397291 {ECO:0000313|EMBL:EOS33216.1, ECO:0000313|Proteomes:UP000014118};
RN   [1] {ECO:0000313|EMBL:EOS33216.1, ECO:0000313|Proteomes:UP000014118}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=A4 {ECO:0000313|EMBL:EOS33216.1,
RC   ECO:0000313|Proteomes:UP000014118};
RG   The Broad Institute Genomics Platform;
RG   The Broad Institute Genome Sequencing Center for Infectious Disease;
RA   Earl A., Xavier R., Elson C., Duck W., Walker B., Young S., Zeng Q.,
RA   Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA   Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA   Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA   Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA   Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA   Birren B.;
RT   "The Genome Sequence of Lachnospiraceae bacterium A4.";
RL   Submitted (APR-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the glycosyl hydrolase 25 family.
CC       {ECO:0000256|ARBA:ARBA00010646}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EOS33216.1}.
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DR   EMBL; ASSR01000047; EOS33216.1; -; Genomic_DNA.
DR   AlphaFoldDB; R9JGU5; -.
DR   STRING; 397291.C804_02405; -.
DR   eggNOG; COG3757; Bacteria.
DR   eggNOG; COG5263; Bacteria.
DR   HOGENOM; CLU_023907_2_0_9; -.
DR   OrthoDB; 9765879at2; -.
DR   Proteomes; UP000014118; Unassembled WGS sequence.
DR   GO; GO:0003796; F:lysozyme activity; IEA:InterPro.
DR   GO; GO:0016998; P:cell wall macromolecule catabolic process; IEA:InterPro.
DR   GO; GO:0009253; P:peptidoglycan catabolic process; IEA:InterPro.
DR   CDD; cd06414; GH25_LytC-like; 1.
DR   Gene3D; 2.10.270.10; Cholin Binding; 4.
DR   Gene3D; 3.20.20.80; Glycosidases; 1.
DR   InterPro; IPR018337; Cell_wall/Cho-bd_repeat.
DR   InterPro; IPR002053; Glyco_hydro_25.
DR   InterPro; IPR017853; Glycoside_hydrolase_SF.
DR   PANTHER; PTHR34135; LYSOZYME; 1.
DR   PANTHER; PTHR34135:SF2; LYSOZYME; 1.
DR   Pfam; PF01473; Choline_bind_1; 3.
DR   Pfam; PF19127; Choline_bind_3; 1.
DR   Pfam; PF01183; Glyco_hydro_25; 1.
DR   SUPFAM; SSF51445; (Trans)glycosidases; 1.
DR   SUPFAM; SSF69360; Cell wall binding repeat; 2.
DR   PROSITE; PS51170; CW; 2.
DR   PROSITE; PS51904; GLYCOSYL_HYDROL_F25_2; 1.
PE   3: Inferred from homology;
KW   Glycosidase {ECO:0000256|ARBA:ARBA00023295};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Reference proteome {ECO:0000313|Proteomes:UP000014118};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..27
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           28..510
FT                   /note="GH25 family lysozyme M1 (1,4-beta-N-
FT                   acetylmuramidase)"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5004484164"
FT   REPEAT          360..379
FT                   /note="Cell wall-binding"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00591"
FT   REPEAT          401..420
FT                   /note="Cell wall-binding"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00591"
SQ   SEQUENCE   510 AA;  57076 MW;  1C142CD474797142 CRC64;
     MKKVTRFLCT LLAVCMLCSV PTMTSEAAVV ERGIDVSKWQ GPINWQAVAQ SGVTFAFIRV
     GNTLKGIDEY FYYNMLAAQQ AGIKTGVYIY SYAKNVQEAA LEAQFVLNAI QNVQVSYPVV
     WDVEDNVHKS LSPEMLSLMA NTFCATVEAE GYYPMVYSSA NWYKDRIGPV FYDKWVAQWA
     ATCDIPDAAV WQYTSKGSVP GVNGNVDMDY ALKDYSASIV NTGWVPRKGY LYYYINYKMQ
     RGWLDLGAAK YYLDPAGRMV TGWLPLEDSL YYLQPDGVMA VGFTPIGLGM YCFGADGKML
     TGLQNLNGLC YYFAQDGAMY TGFLDFPEGK RFFSTDGHMF TGLNIVNNKY YYFDQTGIMQ
     TGWQTIGDQT FLFAADGSMV YGWYNDGVYS YYLSMVDGHR SVGWQTIEGR TYFFDESGHM
     MTGAVTLNGL SYLFAADGTM YTGWFNDGVS AKYYEADGHM AIGLTTIDGS VYYFDINGNM
     QTGIVELDGI PYIFDVDGKM LPQPEPVQLP
//