ID R9JMA7_9FIRM Unreviewed; 487 AA.
AC R9JMA7;
DT 24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2013, sequence version 1.
DT 24-JAN-2024, entry version 40.
DE RecName: Full=Nicotinamide phosphoribosyltransferase {ECO:0000256|ARBA:ARBA00035036};
DE EC=2.4.2.12 {ECO:0000256|ARBA:ARBA00035024};
GN ORFNames=C804_00936 {ECO:0000313|EMBL:EOS35334.1};
OS Lachnospiraceae bacterium A4.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae.
OX NCBI_TaxID=397291 {ECO:0000313|EMBL:EOS35334.1, ECO:0000313|Proteomes:UP000014118};
RN [1] {ECO:0000313|EMBL:EOS35334.1, ECO:0000313|Proteomes:UP000014118}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=A4 {ECO:0000313|EMBL:EOS35334.1,
RC ECO:0000313|Proteomes:UP000014118};
RG The Broad Institute Genomics Platform;
RG The Broad Institute Genome Sequencing Center for Infectious Disease;
RA Earl A., Xavier R., Elson C., Duck W., Walker B., Young S., Zeng Q.,
RA Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Lachnospiraceae bacterium A4.";
RL Submitted (APR-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- PATHWAY: Cofactor biosynthesis; NAD(+) biosynthesis; nicotinamide D-
CC ribonucleotide from 5-phospho-alpha-D-ribose 1-diphosphate and
CC nicotinamide: step 1/1. {ECO:0000256|ARBA:ARBA00035007}.
CC -!- SIMILARITY: Belongs to the NAPRTase family.
CC {ECO:0000256|ARBA:ARBA00010897}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EOS35334.1}.
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DR EMBL; ASSR01000022; EOS35334.1; -; Genomic_DNA.
DR AlphaFoldDB; R9JMA7; -.
DR STRING; 397291.C804_00936; -.
DR PATRIC; fig|397291.3.peg.972; -.
DR eggNOG; COG1488; Bacteria.
DR HOGENOM; CLU_012550_2_0_9; -.
DR OrthoDB; 394882at2; -.
DR Proteomes; UP000014118; Unassembled WGS sequence.
DR GO; GO:0016757; F:glycosyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0009435; P:NAD biosynthetic process; IEA:InterPro.
DR Gene3D; 3.20.20.70; Aldolase class I; 1.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR041529; DUF5598.
DR InterPro; IPR041525; N/Namide_PRibTrfase.
DR InterPro; IPR016471; Nicotinamide_PRibTrfase.
DR InterPro; IPR036068; Nicotinate_pribotase-like_C.
DR PANTHER; PTHR43816; NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE; 1.
DR PANTHER; PTHR43816:SF1; NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE; 1.
DR Pfam; PF18127; NAMPT_N; 1.
DR Pfam; PF04095; NAPRTase; 1.
DR PIRSF; PIRSF005943; NMPRT; 1.
DR SUPFAM; SSF51690; Nicotinate/Quinolinate PRTase C-terminal domain-like; 1.
PE 3: Inferred from homology;
KW Glycosyltransferase {ECO:0000256|ARBA:ARBA00022676};
KW Pyridine nucleotide biosynthesis {ECO:0000256|ARBA:ARBA00022642};
KW Reference proteome {ECO:0000313|Proteomes:UP000014118};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 7..109
FT /note="Nicotinamide phosphoribosyltransferase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF18127"
FT DOMAIN 182..450
FT /note="Nicotinate/nicotinamide phosphoribosyltransferase"
FT /evidence="ECO:0000259|Pfam:PF04095"
SQ SEQUENCE 487 AA; 55266 MW; 57B98E0F5745F4EB CRC64;
MSNTMALLLS DTYKQCHDRM YPTGLTKLVS YWVPRKSMLK TQNKMVFFGL QAFIKEYLIE
YFNDNFFALT KDEVLELYTD SMDIQIGKEN YDWDKIINLH SLGYLPLQIR ALPEGTLVPM
GVPCIEITNT HDGFAWLVQW IECILQVELW KPCCHATIGY MYRQIADKWY EKTVENIPSS
MACADFGMRG MSCMDEATRC SASWLISFDK TSTIPAINYI DKYYSADCKN NRLGIGAVST
EHSVMGANYS IDGDEATFVK RLLNELYPNT SFSMVSDTYD YWNMVNNILP QVKDDVMNHN
GKLLIRPDSG DIVDISVKTV EKLWEIFGGT VNSKGYKVLD PHIGIIYGDG CTLSNVDIIW
SELEIRGFAA NCIAYGVGAF CFSAIVENGN LIVATRDTFG IAMKATYGVI NGKKLMIYKD
PKTDTSKLKK SHKGCCRVYA GENGELICRD ELLEMSDNTL LKAVFENGEL VKEDTFLDIR
ERLYGRR
//