ID   R9KE23_9FIRM            Unreviewed;       619 AA.
AC   R9KE23;
DT   24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT   24-JUL-2013, sequence version 1.
DT   27-MAR-2024, entry version 35.
DE   RecName: Full=Polysaccharide biosynthesis protein CapD-like domain-containing protein {ECO:0000259|Pfam:PF02719};
GN   ORFNames=C809_03371 {ECO:0000313|EMBL:EOS44491.1};
OS   Lachnospiraceae bacterium MD335.
OC   Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae.
OX   NCBI_TaxID=1235793 {ECO:0000313|EMBL:EOS44491.1, ECO:0000313|Proteomes:UP000014081};
RN   [1] {ECO:0000313|EMBL:EOS44491.1, ECO:0000313|Proteomes:UP000014081}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=COE1 {ECO:0000313|EMBL:EOS44491.1,
RC   ECO:0000313|Proteomes:UP000014081};
RG   The Broad Institute Genomics Platform;
RG   The Broad Institute Genome Sequencing Center for Infectious Disease;
RA   Earl A., Xavier R., Elson C., Duck W., Walker B., Young S., Zeng Q.,
RA   Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA   Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA   Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA   Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA   Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA   Birren B.;
RT   "The Genome Sequence of Lachnospiraceae bacterium COE1.";
RL   Submitted (APR-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the polysaccharide synthase family.
CC       {ECO:0000256|ARBA:ARBA00007430}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EOS44491.1}.
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DR   EMBL; ASSW01000055; EOS44491.1; -; Genomic_DNA.
DR   AlphaFoldDB; R9KE23; -.
DR   STRING; 1235793.C809_03371; -.
DR   PATRIC; fig|1235793.3.peg.3500; -.
DR   eggNOG; COG1086; Bacteria.
DR   HOGENOM; CLU_013560_5_2_9; -.
DR   OrthoDB; 9803111at2; -.
DR   Proteomes; UP000014081; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   CDD; cd05237; UDP_invert_4-6DH_SDR_e; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR003869; Polysac_CapD-like.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   PANTHER; PTHR43318:SF1; POLYSACCHARIDE BIOSYNTHESIS PROTEIN EPSC-RELATED; 1.
DR   PANTHER; PTHR43318; UDP-N-ACETYLGLUCOSAMINE 4,6-DEHYDRATASE; 1.
DR   Pfam; PF13727; CoA_binding_3; 1.
DR   Pfam; PF02719; Polysacc_synt_2; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR   SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000014081};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        16..36
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        48..71
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        78..102
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        114..134
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          293..573
FT                   /note="Polysaccharide biosynthesis protein CapD-like"
FT                   /evidence="ECO:0000259|Pfam:PF02719"
SQ   SEQUENCE   619 AA;  69793 MW;  F4F403197068300A CRC64;
     MKLLNHINMQ LLHRRIVLVI IDIMMVCIAS IMPLWIRFEL KYTDIPELYL SSAWNFMVVN
     VVITLLVFYL FKLYHSLWAF AGTAEAQNIV AACCLCAVLN FLGMKLFGYP IPRSYYFMYV
     LVLTGATTVV RFSYRIIRGM KHKHQNKKNG TRVMIIGAGE AGHAVIKEIT NSDFSTMTIK
     CIIDDNETKW GRFILGVKIV GGRDKIVEYA ALYGIDEIII AIPSANRATM KEIVEICKET
     SCKLRTLPGI YQLVNGEVNV SKLRDVDVED LLGRDPIKVD LDSILNYVKN KTIMVTGGGG
     SIGSELCRQI AGHRPARLII VDIYENNAYE IQQELKRNYP RLDLVVLIAS IRNTNRMNDI
     MKTYRPDIIY HAAAHKHVPL MEVSPNEAIK NNVFGTWKTA QAAAQNGVKK FVMISTDKAV
     NPTNIMGASK RICEMIIQTY NRHYDTEFVA VRFGNVLGSN GSVIPLFKQQ IAAGGPVTVT
     HPDIIRYFMT IPEAVSLVLQ AGVYAKGGEI FVLDMGEPVK ILDLAKNLIK LSGYKVDEDI
     KIEFTGLRPG EKLYEELLMN EEGMTDTENK LIHIGKPIEF DESQFYVQLN NLKHAVENEC
     EDVRPLIQEI VPTYIPKEG
//