ID R9KHY8_9FIRM Unreviewed; 678 AA.
AC R9KHY8;
DT 24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2013, sequence version 1.
DT 24-JAN-2024, entry version 30.
DE RecName: Full=beta-galactosidase {ECO:0000256|ARBA:ARBA00012756};
DE EC=3.2.1.23 {ECO:0000256|ARBA:ARBA00012756};
GN ORFNames=C810_02153 {ECO:0000313|EMBL:EOS46055.1};
OS Lachnospiraceae bacterium A2.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae.
OX NCBI_TaxID=397290 {ECO:0000313|EMBL:EOS46055.1, ECO:0000313|Proteomes:UP000014150};
RN [1] {ECO:0000313|EMBL:EOS46055.1, ECO:0000313|Proteomes:UP000014150}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=A2 {ECO:0000313|EMBL:EOS46055.1,
RC ECO:0000313|Proteomes:UP000014150};
RG The Broad Institute Genomics Platform;
RG The Broad Institute Genome Sequencing Center for Infectious Disease;
RA Earl A., Xavier R., Elson C., Duck W., Walker B., Young S., Zeng Q.,
RA Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Lachnospiraceae bacterium A2.";
RL Submitted (APR-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Hydrolysis of terminal non-reducing beta-D-galactose residues
CC in beta-D-galactosides.; EC=3.2.1.23;
CC Evidence={ECO:0000256|ARBA:ARBA00001412};
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 42 family.
CC {ECO:0000256|ARBA:ARBA00005940}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EOS46055.1}.
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DR EMBL; ASSX01000009; EOS46055.1; -; Genomic_DNA.
DR AlphaFoldDB; R9KHY8; -.
DR STRING; 397290.C810_02153; -.
DR PATRIC; fig|397290.3.peg.2366; -.
DR eggNOG; COG1874; Bacteria.
DR HOGENOM; CLU_012430_2_0_9; -.
DR Proteomes; UP000014150; Unassembled WGS sequence.
DR GO; GO:0009341; C:beta-galactosidase complex; IEA:InterPro.
DR GO; GO:0004565; F:beta-galactosidase activity; IEA:UniProtKB-EC.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR CDD; cd03143; A4_beta-galactosidase_middle_domain; 1.
DR Gene3D; 3.40.50.880; -; 1.
DR Gene3D; 3.20.20.80; Glycosidases; 1.
DR InterPro; IPR013738; Beta_galactosidase_Trimer.
DR InterPro; IPR029062; Class_I_gatase-like.
DR InterPro; IPR003476; Glyco_hydro_42.
DR InterPro; IPR013529; Glyco_hydro_42_N.
DR InterPro; IPR017853; Glycoside_hydrolase_SF.
DR PANTHER; PTHR36447; BETA-GALACTOSIDASE GANA; 1.
DR PANTHER; PTHR36447:SF2; BETA-GALACTOSIDASE YESZ; 1.
DR Pfam; PF02449; Glyco_hydro_42; 1.
DR Pfam; PF08532; Glyco_hydro_42M; 1.
DR SUPFAM; SSF51445; (Trans)glycosidases; 1.
DR SUPFAM; SSF52317; Class I glutamine amidotransferase-like; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000014150}.
FT DOMAIN 18..385
FT /note="Glycoside hydrolase family 42 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF02449"
FT DOMAIN 399..608
FT /note="Beta-galactosidase trimerisation"
FT /evidence="ECO:0000259|Pfam:PF08532"
SQ SEQUENCE 678 AA; 77917 MW; 27541476A73E379A CRC64;
MEKFMEKDRK QLLFGAAYYD EYMPYERLDK DVEMMKKAGI NTVRIAESTW STCEPQEGVF
DFSHVERVMN AMEQAGIHVI IGTPTYAVPT WMVKSHPDIL AETVKGRGIY GPRQIMDITH
PVYRFYAERV IRRLMECTAH RTCVIGFQLD NETKHYGTAG RNVQEQFVKY LRQKFHDDLD
TMNQEFGLDY WSNRVNAWED FPDVRGTING SLGAEFEKFQ RGLVTEFLSW QAGIVNEYRR
EGQFITHNFD YEWRGHSFGV QPDVNHFHAS RCLTLTGADI YHPSQDELTG TEIAFGGDMA
RSLKNDNYLI LETEAQGFPG WTPYKGQLRL QAYSHIASGA NGVMYWHWHS IHNSFETYWK
GILSHDFQEN DTYREACAIG REFSEIGSHL MNLKKKNDVA VLVSNEALTA LKWFGIEATA
AGNAGIGYND VVRWIYDVLY ERNMECDFIW PESENLNEYK VIIVPALYAA PEELLQKLVR
YVEGGGYLAA TFKTAFADEN VKVSHEVQPH ILHKCFGVEY QQFAFPKHTG LTGKIIGDAE
EVEADVFMEL LIPHGAEVLA SYDHYNWNGY AAVTENSYGN GKAFYLGCMT DKKILWRILE
YVLRAAAVQI PDENFPVIVR QGKNDFGKTV KFYFNYSAEG RNVTYRFSDS TELLSGAEIK
SREEFEIPAW GVKIMEEK
//
