ID R9M303_9FIRM Unreviewed; 635 AA.
AC R9M303;
DT 24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2013, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE SubName: Full=M3 family oligoendopeptidase {ECO:0000313|EMBL:EOS65340.1};
GN ORFNames=C816_02121 {ECO:0000313|EMBL:EOS65340.1};
OS Oscillibacter sp. 1-3.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Oscillospiraceae;
OC Oscillibacter.
OX NCBI_TaxID=1235797 {ECO:0000313|EMBL:EOS65340.1, ECO:0000313|Proteomes:UP000014108};
RN [1] {ECO:0000313|EMBL:EOS65340.1, ECO:0000313|Proteomes:UP000014108}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=1-3 {ECO:0000313|EMBL:EOS65340.1,
RC ECO:0000313|Proteomes:UP000014108};
RG The Broad Institute Genomics Platform;
RG The Broad Institute Genome Sequencing Center for Infectious Disease;
RA Earl A., Xavier R., Elson C., Duck W., Walker B., Young S., Zeng Q.,
RA Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Oscillibacter bacterium 1-3.";
RL Submitted (APR-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|RuleBase:RU003435};
CC Note=Binds 1 zinc ion. {ECO:0000256|RuleBase:RU003435};
CC -!- SIMILARITY: Belongs to the peptidase M3 family.
CC {ECO:0000256|RuleBase:RU003435}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EOS65340.1}.
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DR EMBL; ASTC01000015; EOS65340.1; -; Genomic_DNA.
DR RefSeq; WP_016322410.1; NZ_KE159708.1.
DR AlphaFoldDB; R9M303; -.
DR STRING; 1235797.C816_02121; -.
DR PATRIC; fig|1235797.3.peg.2339; -.
DR eggNOG; COG1164; Bacteria.
DR HOGENOM; CLU_030403_2_0_9; -.
DR OrthoDB; 9762795at2; -.
DR Proteomes; UP000014108; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR Gene3D; 1.10.1370.30; -; 1.
DR InterPro; IPR001567; Pept_M3A_M3B_dom.
DR Pfam; PF01432; Peptidase_M3; 1.
DR SUPFAM; SSF55486; Metalloproteases ('zincins'), catalytic domain; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|RuleBase:RU003435};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|RuleBase:RU003435};
KW Metalloprotease {ECO:0000256|RuleBase:RU003435};
KW Protease {ECO:0000256|RuleBase:RU003435};
KW Reference proteome {ECO:0000313|Proteomes:UP000014108};
KW Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Zinc {ECO:0000256|RuleBase:RU003435}.
FT SIGNAL 1..27
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 28..635
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004486049"
FT TRANSMEM 593..615
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 375..565
FT /note="Peptidase M3A/M3B catalytic"
FT /evidence="ECO:0000259|Pfam:PF01432"
SQ SEQUENCE 635 AA; 71610 MW; 9547096EFCB36D41 CRC64;
MKKTFRALRL GAILLAACLT LTLPAQAAAR YPEKEHLPVD FADMEYTGYD GAALRSALSA
LEQIAASPAA QTEDAEIRAA LEALYGRILS EVDQLSTQSA LIGIRYDANG ADQEAADESA
ALSQLSVQLF DECYRTLGLL ADTPYRDILE RDAGPEILDE LRNYQALTAR EAALYEEEER
LVQAYDQAMA QPVQAVREGQ VWTEESLAQD RELDDETWWE ISAQLERERN RAAGEIFLQL
VRVRTEIAKE NGYDSYADYA YRESYGRDYT TEDIEAVRRA AKRYWVPLEA RLMDALSQRD
LRALDVRTRA YGDDILDAVE PYMARIDPEL AETFAFMRQY HLYDIAPSDS KLPVGYTVGL
PAYGTAFIFD DPYGDHQDYS TVIHEFGHFN ETFHSAEHDL WSSFHIDVGE IHSQGLEVLF
TAYAGEMFGP EGGRAFYWAT ISNMVSSVLE GCMYDEFQTA VYEDPDMTLE EVNRLFKDIS
EEYGYSYEGD GEESYFWVEI THNFQSPMYY ISYATSALSA LDLWLISLED WDTAVDIYLD
LAAMGLSQPY RETVEAVGLR DIFHERTMRL LADGIQDRLS EETGERGSWE LPVVLLGAGF
GGAVILIAAG ALLVCRRRRR AAALAQAAET PWELP
//
