ID   R9MH45_9FIRM            Unreviewed;      1227 AA.
AC   R9MH45;
DT   24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT   24-JUL-2013, sequence version 1.
DT   24-JAN-2024, entry version 32.
DE   RecName: Full=BIG2 domain-containing protein {ECO:0000259|SMART:SM00635};
GN   ORFNames=C818_01804 {ECO:0000313|EMBL:EOS70389.1};
OS   Lachnospiraceae bacterium MD308.
OC   Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae.
OX   NCBI_TaxID=1235799 {ECO:0000313|EMBL:EOS70389.1, ECO:0000313|Proteomes:UP000014117};
RN   [1] {ECO:0000313|EMBL:EOS70389.1, ECO:0000313|Proteomes:UP000014117}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=3-2 {ECO:0000313|EMBL:EOS70389.1,
RC   ECO:0000313|Proteomes:UP000014117};
RG   The Broad Institute Genomics Platform;
RG   The Broad Institute Genome Sequencing Center for Infectious Disease;
RA   Earl A., Xavier R., Elson C., Duck W., Walker B., Young S., Zeng Q.,
RA   Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA   Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA   Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA   Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA   Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA   Birren B.;
RT   "The Genome Sequence of Lachnospiraceae bacterium 3-2.";
RL   Submitted (APR-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EOS70389.1}.
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DR   EMBL; ASTE01000019; EOS70389.1; -; Genomic_DNA.
DR   AlphaFoldDB; R9MH45; -.
DR   STRING; 1235799.C818_01804; -.
DR   PATRIC; fig|1235799.3.peg.1922; -.
DR   eggNOG; COG5492; Bacteria.
DR   HOGENOM; CLU_268041_0_0_9; -.
DR   OrthoDB; 2042388at2; -.
DR   Proteomes; UP000014117; Unassembled WGS sequence.
DR   Gene3D; 2.60.40.1080; -; 2.
DR   InterPro; IPR003343; Big_2.
DR   InterPro; IPR008964; Invasin/intimin_cell_adhesion.
DR   Pfam; PF02368; Big_2; 2.
DR   SMART; SM00635; BID_2; 2.
DR   SUPFAM; SSF49373; Invasin/intimin cell-adhesion fragments; 2.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000014117};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           20..1227
FT                   /note="BIG2 domain-containing protein"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5038373901"
FT   DOMAIN          1059..1134
FT                   /note="BIG2"
FT                   /evidence="ECO:0000259|SMART:SM00635"
FT   DOMAIN          1146..1224
FT                   /note="BIG2"
FT                   /evidence="ECO:0000259|SMART:SM00635"
FT   REGION          35..105
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        42..58
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        59..85
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        86..105
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1227 AA;  137042 MW;  E112A83847125CD8 CRC64;
     MKKRYLAMLL AIAIVFAQAV GTGQVVLAAQ IAEEEQQGED AAQEKEAEIE KTEEEKTEGE
     EIVTDVPENG DEKEDADEEQ NEGDVQPEEE GKKEEVVEKK RAAALPEDKQ GVGEITILPA
     EGTELRGSSD WTWLFENETQ TFHVDVDGSN TVQWEIGRYT EDSTEAFNEG VPGNPVTWKI
     SEDGKSITVT AKSESSGLFI SASCGDAQHQ ILVDVKKRKM IPNIWVGREE KIEDFPGEYF
     ISKTNGGDCY VENEDYPNGE ELPLTILSIK SEDENIASIG EEGTEWVLQL KKLGQTNIII
     KCCLQNDETQ TFEKKIPVHV KNEVYSMDLM TSTGSTEMLF DDSLELTANV QGSLWNDSEE
     EITPIDTKGL RVEWTYEVSS YGNDGEDDSA EVTKKVKLEP NADNSRACHI TAGKADHHYE
     VVVRVKAYKD SEEVASDVIE LSVNDFYNLL EPVSINTDIL PEEVMEISGV GVYRYQVGKE
     KELIKDIKIS FEYDPEILEI TKGDQAISSG DDPKLEAGGN FIVKRLSPKD TLLRVNSWVQ
     EEDGQWDYAE TREWWFESCD YNDICFEKDS YEIFASDDPE ENETIDMKLN TESIEAEHTV
     EWTVGLMSED GVFEQTIDPS NYTASGNVLT LDGNQIKNAL KALGQEREYL WVSVLAVVKI
     SGTEVGSTYS VVDIKTPEYE LESVYDRTEV LSTWLYYDKE ISCHVENKNY PEGADIAVTL
     LDIVIEQEER VWKKEEDASG IILNAVGCGE AKVTFKTQSK ELGEKDFTVN MNVTDDMYHI
     YANDGRDYIQ LLPGKSHKLK VEVYHSYYDS KIEGIKEEKV NAPFSYLTYD SFDEEVISVK
     DGTITAKTPL EIPMYSNLRI HLSVPREGRE NFECDELLHV EVTNCYYQAV AEKMYVEPGE
     VVSSVPVKLL RFDTEHENGI EEKGITYSLD DEWNVTFNKD KTGFTVGNDL EDGETFEISV
     IVEKKVGDEE IREFGQLELE ICKHSFVVKS TKQDNCTVEG VKTLECSKCH TAKTETIPKT
     SHSYGAWQTT REATVFAQGA QVRTCRRCRA SETRTLAKLK PFIKLNAKTI PLKVKQSTTA
     VKVTMEKGDS IASWKSSNKK IATVNSKGKI TGKKAGTAKI TVTLKSGVKA TIKVKVQKKA
     VTTSKISVTG KTSKIGKKLT LKKGKSATLA VTVTPITSKE KVTYKSSNKK VAAVTSKGKI
     TAKKPGKAKI TVKSGKKKVV ITVTVKK
//