ID R9MUC8_9FIRM Unreviewed; 769 AA.
AC R9MUC8;
DT 24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2013, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE RecName: Full=mannose-6-phosphate isomerase {ECO:0000256|ARBA:ARBA00011956};
DE EC=5.3.1.8 {ECO:0000256|ARBA:ARBA00011956};
DE AltName: Full=Phosphohexomutase {ECO:0000256|ARBA:ARBA00029741};
DE AltName: Full=Phosphomannose isomerase {ECO:0000256|ARBA:ARBA00030762};
GN ORFNames=C818_00830 {ECO:0000313|EMBL:EOS71372.1};
OS Lachnospiraceae bacterium MD308.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae.
OX NCBI_TaxID=1235799 {ECO:0000313|EMBL:EOS71372.1, ECO:0000313|Proteomes:UP000014117};
RN [1] {ECO:0000313|EMBL:EOS71372.1, ECO:0000313|Proteomes:UP000014117}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=3-2 {ECO:0000313|EMBL:EOS71372.1,
RC ECO:0000313|Proteomes:UP000014117};
RG The Broad Institute Genomics Platform;
RG The Broad Institute Genome Sequencing Center for Infectious Disease;
RA Earl A., Xavier R., Elson C., Duck W., Walker B., Young S., Zeng Q.,
RA Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Lachnospiraceae bacterium 3-2.";
RL Submitted (APR-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=D-mannose 6-phosphate = D-fructose 6-phosphate;
CC Xref=Rhea:RHEA:12356, ChEBI:CHEBI:58735, ChEBI:CHEBI:61527;
CC EC=5.3.1.8; Evidence={ECO:0000256|ARBA:ARBA00000757};
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|ARBA:ARBA00001947};
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 1 family.
CC {ECO:0000256|ARBA:ARBA00010838}.
CC -!- SIMILARITY: Belongs to the mannose-6-phosphate isomerase type 1 family.
CC {ECO:0000256|ARBA:ARBA00010772}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EOS71372.1}.
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DR EMBL; ASTE01000010; EOS71372.1; -; Genomic_DNA.
DR AlphaFoldDB; R9MUC8; -.
DR STRING; 1235799.C818_00830; -.
DR PATRIC; fig|1235799.3.peg.887; -.
DR eggNOG; COG1482; Bacteria.
DR eggNOG; COG2723; Bacteria.
DR HOGENOM; CLU_020529_4_0_9; -.
DR OrthoDB; 9808275at2; -.
DR Proteomes; UP000014117; Unassembled WGS sequence.
DR GO; GO:0004553; F:hydrolase activity, hydrolyzing O-glycosyl compounds; IEA:InterPro.
DR GO; GO:0004476; F:mannose-6-phosphate isomerase activity; IEA:UniProtKB-EC.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR CDD; cd07010; cupin_PMI_type_I_N_bac; 1.
DR Gene3D; 3.20.20.80; Glycosidases; 1.
DR Gene3D; 2.60.120.10; Jelly Rolls; 2.
DR InterPro; IPR001360; Glyco_hydro_1.
DR InterPro; IPR018120; Glyco_hydro_1_AS.
DR InterPro; IPR017853; Glycoside_hydrolase_SF.
DR InterPro; IPR001250; Man6P_Isoase-1.
DR InterPro; IPR049071; MPI_cupin_dom.
DR InterPro; IPR046457; PMI_typeI_cat.
DR InterPro; IPR014710; RmlC-like_jellyroll.
DR InterPro; IPR011051; RmlC_Cupin_sf.
DR NCBIfam; TIGR00218; manA; 1.
DR PANTHER; PTHR10353; GLYCOSYL HYDROLASE; 1.
DR PANTHER; PTHR10353:SF36; KLOTHO (MAMMALIAN AGING-ASSOCIATED PROTEIN) HOMOLOG; 1.
DR Pfam; PF00232; Glyco_hydro_1; 1.
DR Pfam; PF21621; MPI_cupin_dom; 1.
DR Pfam; PF20511; PMI_typeI_cat; 1.
DR PRINTS; PR00131; GLHYDRLASE1.
DR SUPFAM; SSF51445; (Trans)glycosidases; 1.
DR SUPFAM; SSF51182; RmlC-like cupins; 1.
DR PROSITE; PS00572; GLYCOSYL_HYDROL_F1_1; 1.
PE 3: Inferred from homology;
KW Glycosidase {ECO:0000256|ARBA:ARBA00023295};
KW Hydrolase {ECO:0000256|ARBA:ARBA00023295};
KW Isomerase {ECO:0000256|ARBA:ARBA00023235};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000014117};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT DOMAIN 463..561
FT /note="Phosphomannose isomerase type I catalytic"
FT /evidence="ECO:0000259|Pfam:PF20511"
FT DOMAIN 698..767
FT /note="Mannose-6-phosphate isomerase cupin"
FT /evidence="ECO:0000259|Pfam:PF21621"
FT ACT_SITE 357
FT /note="Nucleophile"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10055"
SQ SEQUENCE 769 AA; 87911 MW; 041ECAC1964F821E CRC64;
MFRGDFIWGV ASSAYQIEGK GVKEVAGECI WDRFVKEAGR IADGADADVS CDFIRKYKED
ISLMKYMGIR NYRFSLNWSR IMPEGTGQVN ERAVRMYRDM IKFMKEKGIE PFITLFHWEY
PQSLQERGGW VSSQSPEWFG RYARVVAENF SDLCEYFITI DEPQCFCNFG HVRGTHAPGY
KLPLPLSFQM VHNVLKAHGM AVKALREYAK GPVKAGIAPT FGVPVPESEE TSDIEAAKRA
YFGFYEETDN WAWNLSWYLD PVIFGKYPEE GLEKYAAYLP RFSAEDMELI SQPVDFIGQG
IYNGHAVRAG DMGEPVFLER KPGAPKTAVG WSVMPECMYW GCRFLYERYK TPVFITENGM
SALDVVSEDG RVHDQNRINY LDAHISQLQR AYDEGVDIRG YFLWTFLDNF EWERGYNERF
GIVYVDFESL KRTVKDSACW YQQVIGQNGA NLSINRKPRP ILFLNPVLKE MVWGGNRLGT
DFGYQLPGNE VGECWGISAH PSGDDGVDDS RFVGKTLSEL WEKERYLFGN LKEDRFPLLV
KVIDAKENLS IQVHPDDIYA KEHEGGSLGK TECWYIIDCG EDAELVVGHN ARTKKELERM
IHEGRWDALI RKIPIKKGDF IQINPGCVHA ITAGCMILET QQNSDITYRV YDYGRLKDGK
PRELHVEKSM DVIKVPAQPA ADSVKNVKEI PENQWIKLIA CDYYKVYKMN LNGMMRFTQT
HPFMNVSVIE GCGIVNGRVI KKGDHFILPD GYGSVELTGE MELIASTVY
//