ID R9P070_PSEHS Unreviewed; 1150 AA.
AC R9P070;
DT 24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2013, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE RecName: Full=Pseudouridine synthase {ECO:0008006|Google:ProtNLM};
GN ORFNames=PHSY_002088 {ECO:0000313|EMBL:GAC94516.1};
OS Pseudozyma hubeiensis (strain SY62) (Yeast).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Ustilaginomycotina;
OC Ustilaginomycetes; Ustilaginales; Ustilaginaceae; Pseudozyma.
OX NCBI_TaxID=1305764 {ECO:0000313|EMBL:GAC94516.1, ECO:0000313|Proteomes:UP000014071};
RN [1] {ECO:0000313|Proteomes:UP000014071}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SY62 {ECO:0000313|Proteomes:UP000014071};
RX PubMed=23814110; DOI=10.1128/genomea.00409-13;
RA Konishi M., Hatada Y., Horiuchi J.;
RT "Draft genome sequence of the basidiomycetous yeast-like fungus Pseudozyma
RT hubeiensis SY62, which produces an abundant amount of the biosurfactant
RT mannosylerythritol lipids.";
RL Genome Announc. 1:E0040913-E0040913(2013).
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DR EMBL; DF238784; GAC94516.1; -; Genomic_DNA.
DR RefSeq; XP_012188103.1; XM_012332713.1.
DR AlphaFoldDB; R9P070; -.
DR STRING; 1305764.R9P070; -.
DR GeneID; 24107382; -.
DR eggNOG; KOG1919; Eukaryota.
DR HOGENOM; CLU_291895_0_0_1; -.
DR OrthoDB; 5479603at2759; -.
DR Proteomes; UP000014071; Unassembled WGS sequence.
DR GO; GO:0009982; F:pseudouridine synthase activity; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0034470; P:ncRNA processing; IEA:UniProt.
DR GO; GO:0001522; P:pseudouridine synthesis; IEA:InterPro.
DR CDD; cd02440; AdoMet_MTases; 1.
DR CDD; cd02557; PseudoU_synth_ScRIB2; 1.
DR Gene3D; 3.30.2350.10; Pseudouridine synthase; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR020103; PsdUridine_synth_cat_dom_sf.
DR InterPro; IPR006225; PsdUridine_synth_RluC/D.
DR InterPro; IPR006145; PsdUridine_synth_RsuA/RluA.
DR InterPro; IPR000241; RlmKL-like_Mtase.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR NCBIfam; TIGR00005; rluA_subfam; 1.
DR PANTHER; PTHR21600; MITOCHONDRIAL RNA PSEUDOURIDINE SYNTHASE; 1.
DR PANTHER; PTHR21600:SF40; PSEUDOURIDYLATE SYNTHASE RPUSD2; 1.
DR Pfam; PF00849; PseudoU_synth_2; 1.
DR Pfam; PF01170; UPF0020; 1.
DR SUPFAM; SSF55120; Pseudouridine synthase; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000014071}.
FT DOMAIN 118..265
FT /note="Pseudouridine synthase RsuA/RluA-like"
FT /evidence="ECO:0000259|Pfam:PF00849"
FT DOMAIN 945..1093
FT /note="UPF0020"
FT /evidence="ECO:0000259|Pfam:PF01170"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 160
FT /evidence="ECO:0000256|PIRSR:PIRSR606225-1"
SQ SEQUENCE 1150 AA; 127205 MW; 3DAB4CEBB162C699 CRC64;
MMGHHRGVEA INSATGTTSR QNGLRKTTPY WYEFQTYSKL RWFGRELIEI MTTEFRDRTK
EYYVWAIHKG ICTVNGKKAD IHQTIGDGDK ICNSVHRHEP PVTDEPIKII HRDDEEGILV
IVKPGSIPVH AAGRYLRHTL TGLLQSEHGI EMVYTTNRLD RLTSGIMVCS TKKETASRLG
AQFAAGQVSK AYVCRVRGKF PEGEVVCKEP ILTIDRQSGV NIVHPKGKHC ETIFVRLSYD
AATDSSVVFC RPITGRTHQI RVHVQYLGHP ICNDPIYGHN VWSKVDSSAF AKVIPDQWKK
VGGEIGQKEV EMIVDAIKGD QDGQEDWARW KDEVLFKEMI AQEGLENVHV PGPNGRSSRP
SDDLLKRALA KLELDTGDIP AKGLNRPKDI ETAWQKRVRE QSSDFCSECK IPLLPDPKPE
ELYIYLHAIK YWSDEWSFED ALPWWAREDW QSISPHGSGT GSGAAEATLP QDLAVAHKTE
AELSSAAISS LITSEIEEKA SRLAEPQKYT KHDQGIELSQ VMQLVDYPPM HVGPSSSSSK
IAVATEAINV PIVFQVFGGF EDFAQREVLQ QTLARAAEHA VTLTSECGTS SSIHSGHVRV
LDGKLARCSL AAYLDAKLGI AKTAYLLTAL HEFPRELAKE LKHEKHIGGA SKRARWKAKE
LRRSLAKKEG KKLGTQPTTP GIIGKPTILR GDVVTDDTAA SAAKVLLDAE QSGMKSESIG
VNAAVEQVPS SAASEAEADD GSPFPSEVRL LQLLDDVWES SLPQLDRALE SWKRIVSATT
GEPFTETHHT YRATVDRATY NLPSLNSQTM ERYVGELAWD WLNGRDTPNT QPSAPTTWRV
DLEKPMLDIT LKFFPGFGIG DEFEKELGEE DDPALKSEGQ IAFMIKLPAP ITASPRRPAG
RNAFLVGGTT MAEYRAASLA LALPLPTERK TLDGVQSAKE LAPLRVLEPC CGHGSIVFQT
AAMMEARGLH GEVLGCDIDA ETVERAQSIS TLAGFDPTTG PVTVQLRSVD GTDRLSLESF
AGGASSIDAI LTDLPWGKRE KASQSLSKLY HFFLESWFSV LRTGGYIVAV TAEHRTLSRA
LSVFETTCRK KRMGACLKME DVRMLDGRGN GFEEEKVKQQ GVLEARRNGQ MRKIEIGYHV
YVFMIRKVAI
//
