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Database: UniProt
Entry: R9PY25_DROME
LinkDB: R9PY25_DROME
Original site: R9PY25_DROME 
ID   R9PY25_DROME            Unreviewed;      2224 AA.
AC   R9PY25;
DT   24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT   11-JUN-2014, sequence version 2.
DT   25-OCT-2017, entry version 45.
DE   SubName: Full=Narrow abdomen, isoform G {ECO:0000313|EMBL:AAF48365.4};
GN   Name=na {ECO:0000313|EMBL:AAF48365.4,
GN   ECO:0000313|FlyBase:FBgn0002917};
GN   Synonyms=alpha1U {ECO:0000313|EMBL:AAF48365.4}, CG1517
GN   {ECO:0000313|EMBL:AAF48365.4, ECO:0000313|FlyBase:FBgn0002917}, Dma1U
GN   {ECO:0000313|EMBL:AAF48365.4}, Dmalpha1U
GN   {ECO:0000313|EMBL:AAF48365.4}, Dmel\CG1517
GN   {ECO:0000313|EMBL:AAF48365.4}, har {ECO:0000313|EMBL:AAF48365.4}, har
GN   38 {ECO:0000313|EMBL:AAF48365.4}, har 85
GN   {ECO:0000313|EMBL:AAF48365.4}, har38 {ECO:0000313|EMBL:AAF48365.4},
GN   har85 {ECO:0000313|EMBL:AAF48365.4}, harA
GN   {ECO:0000313|EMBL:AAF48365.4}, NA {ECO:0000313|EMBL:AAF48365.4}, Na
GN   {ECO:0000313|EMBL:AAF48365.4}, NALCN {ECO:0000313|EMBL:AAF48365.4};
GN   ORFNames=Dmel_CG1517 {ECO:0000313|EMBL:AAF48365.4};
OS   Drosophila melanogaster (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
OC   Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha;
OC   Ephydroidea; Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7227 {ECO:0000313|EMBL:AAF48365.4, ECO:0000313|Proteomes:UP000000803};
RN   [1] {ECO:0000313|EMBL:AAF48365.4, ECO:0000313|Proteomes:UP000000803}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX   PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA   Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA   Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA   George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA   Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X.,
RA   Brandon R.C., Rogers Y.H., Blazej R.G., Champe M., Pfeiffer B.D.,
RA   Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Gabor G.L.,
RA   Abril J.F., Agbayani A., An H.J., Andrews-Pfannkoch C., Baldwin D.,
RA   Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M.,
RA   Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S.,
RA   Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P.,
RA   Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I.,
RA   Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P.,
RA   de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M.,
RA   Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P.,
RA   Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W.,
RA   Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K.,
RA   Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA   Harris N.L., Harvey D., Heiman T.J., Hernandez J.R., Houck J.,
RA   Hostin D., Houston K.A., Howland T.J., Wei M.H., Ibegwam C.,
RA   Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A.,
RA   Kimmel B.E., Kodira C.D., Kraft C., Kravitz S., Kulp D., Lai Z.,
RA   Lasko P., Lei Y., Levitsky A.A., Li J., Li Z., Liang Y., Lin X.,
RA   Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D.,
RA   Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A.,
RA   Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L.,
RA   Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M.,
RA   Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G.,
RA   Reinert K., Remington K., Saunders R.D., Scheeler F., Shen H.,
RA   Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.,
RA   Spier E., Spradling A.C., Stapleton M., Strong R., Sun E.,
RA   Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X.,
RA   Wang Z.Y., Wassarman D.A., Weinstock G.M., Weissenbach J.,
RA   Williams S.M., WoodageT, Worley K.C., Wu D., Yang S., Yao Q.A., Ye J.,
RA   Yeh R.F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L.,
RA   Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S., Zhu X., Smith H.O.,
RA   Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.;
RT   "The genome sequence of Drosophila melanogaster.";
RL   Science 287:2185-2195(2000).
RN   [2] {ECO:0000313|EMBL:AAF48365.4, ECO:0000313|Proteomes:UP000000803}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX   PubMed=12537568;
RA   Celniker S.E., Wheeler D.A., Kronmiller B., Carlson J.W., Halpern A.,
RA   Patel S., Adams M., Champe M., Dugan S.P., Frise E., Hodgson A.,
RA   George R.A., Hoskins R.A., Laverty T., Muzny D.M., Nelson C.R.,
RA   Pacleb J.M., Park S., Pfeiffer B.D., Richards S., Sodergren E.J.,
RA   Svirskas R., Tabor P.E., Wan K., Stapleton M., Sutton G.G., Venter C.,
RA   Weinstock G., Scherer S.E., Myers E.W., Gibbs R.A., Rubin G.M.;
RT   "Finishing a whole-genome shotgun: release 3 of the Drosophila
RT   melanogaster euchromatic genome sequence.";
RL   Genome Biol. 3:RESEARCH0079-RESEARCH0079(2002).
RN   [3] {ECO:0000313|EMBL:AAF48365.4, ECO:0000313|Proteomes:UP000000803}
RP   GENOME REANNOTATION.
RC   STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX   PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA   Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA   Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA   Smith C.D., Tupy J.L., Whitfied E.J., Bayraktaroglu L., Berman B.P.,
RA   Bettencourt B.R., Celniker S.E., de Grey A.D., Drysdale R.A.,
RA   Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q.,
RA   Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M.,
RA   Lewis S.E.;
RT   "Annotation of the Drosophila melanogaster euchromatic genome: a
RT   systematic review.";
RL   Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN   [4] {ECO:0000313|EMBL:AAF48365.4, ECO:0000313|Proteomes:UP000000803}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX   PubMed=12537573;
RA   Kaminker J.S., Bergman C.M., Kronmiller B., Carlson J., Svirskas R.,
RA   Patel S., Frise E., Wheeler D.A., Lewis S.E., Rubin G.M.,
RA   Ashburner M., Celniker S.E.;
RT   "The transposable elements of the Drosophila melanogaster euchromatin:
RT   a genomics perspective.";
RL   Genome Biol. 3:RESEARCH0084.1-RESEARCH0084.20(2002).
RN   [5] {ECO:0000313|EMBL:AAF48365.4, ECO:0000313|Proteomes:UP000000803}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX   PubMed=12537574;
RA   Hoskins R.A., Smith C.D., Carlson J.W., Carvalho A.B., Halpern A.,
RA   Kaminker J.S., Kennedy C., Mungall C.J., Sullivan B.A., Sutton G.G.,
RA   Yasuhara J.C., Wakimoto B.T., Myers E.W., Celniker S.E., Rubin G.M.,
RA   Karpen G.H.;
RT   "Heterochromatic sequences in a Drosophila whole-genome shotgun
RT   assembly.";
RL   Genome Biol. 3:RESEARCH0085-RESEARCH0085(2002).
RN   [6] {ECO:0000313|EMBL:AAF48365.4, ECO:0000313|Proteomes:UP000000803}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX   PubMed=16110336; DOI=10.1371/journal.pcbi.0010022;
RA   Quesneville H., Bergman C.M., Andrieu O., Autard D., Nouaud D.,
RA   Ashburner M., Anxolabehere D.;
RT   "Combined evidence annotation of transposable elements in genome
RT   sequences.";
RL   PLoS Comput. Biol. 1:166-175(2005).
RN   [7] {ECO:0000313|EMBL:AAF48365.4, ECO:0000313|Proteomes:UP000000803}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX   PubMed=17569856; DOI=10.1126/science.1139815;
RA   Smith C.D., Shu S., Mungall C.J., Karpen G.H.;
RT   "The Release 5.1 annotation of Drosophila melanogaster
RT   heterochromatin.";
RL   Science 316:1586-1591(2007).
RN   [8] {ECO:0000313|EMBL:AAF48365.4, ECO:0000313|Proteomes:UP000000803}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX   PubMed=17569867; DOI=10.1126/science.1139816;
RA   Hoskins R.A., Carlson J.W., Kennedy C., Acevedo D., Evans-Holm M.,
RA   Frise E., Wan K.H., Park S., Mendez-Lago M., Rossi F., Villasante A.,
RA   Dimitri P., Karpen G.H., Celniker S.E.;
RT   "Sequence finishing and mapping of Drosophila melanogaster
RT   heterochromatin.";
RL   Science 316:1625-1628(2007).
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DR   EMBL; AE014298; AAF48365.4; -; Genomic_DNA.
DR   RefSeq; NP_727772.3; NM_167401.3.
DR   PaxDb; R9PY25; -.
DR   EnsemblMetazoa; FBtr0344822; FBpp0311138; FBgn0002917.
DR   EnsemblMetazoa; FBtr0344823; FBpp0311139; FBgn0002917.
DR   GeneID; 45338; -.
DR   CTD; 45338; -.
DR   FlyBase; FBgn0002917; na.
DR   eggNOG; KOG2301; Eukaryota.
DR   eggNOG; ENOG410XNP6; LUCA.
DR   GeneTree; ENSGT00830000128247; -.
DR   OrthoDB; EOG091G00F9; -.
DR   Reactome; R-DME-2672351; Stimuli-sensing channels.
DR   GenomeRNAi; 45338; -.
DR   Proteomes; UP000000803; Chromosome X.
DR   Bgee; FBgn0002917; -.
DR   GO; GO:0043679; C:axon terminus; IDA:FlyBase.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0043025; C:neuronal cell body; IDA:FlyBase.
DR   GO; GO:0005261; F:cation channel activity; IEA:InterPro.
DR   GO; GO:0005216; F:ion channel activity; IMP:FlyBase.
DR   GO; GO:0008344; P:adult locomotory behavior; IMP:FlyBase.
DR   GO; GO:0048512; P:circadian behavior; IDA:FlyBase.
DR   GO; GO:0045475; P:locomotor rhythm; IMP:FlyBase.
DR   GO; GO:0042752; P:regulation of circadian rhythm; IMP:FlyBase.
DR   GO; GO:0072347; P:response to anesthetic; IMP:FlyBase.
DR   GO; GO:0050975; P:sensory perception of touch; IMP:FlyBase.
DR   GO; GO:0035176; P:social behavior; IMP:FlyBase.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR028823; NALCN.
DR   PANTHER; PTHR10037:SF214; PTHR10037:SF214; 1.
DR   Pfam; PF00520; Ion_trans; 4.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000000803};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000803};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    429    450       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    498    520       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    621    644       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    710    730       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    742    765       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    777    794       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    833    852       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    900    923       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1209   1233       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1253   1271       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1283   1302       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1345   1364       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1461   1484       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1542   1561       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1567   1585       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1627   1643       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1663   1684       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1750   1772       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      360    654       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      706    927       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1215   1489       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1537   1783       Ion_trans. {ECO:0000259|Pfam:PF00520}.
SQ   SEQUENCE   2224 AA;  246073 MW;  86D7B9629424AB8D CRC64;
     MIDRLQIRRL GAAARNKRAG GGGGAGGGAV GSGGAGGGGG GGGAGAVPGA AGAAGTGPIT
     GASATAASGS SGSGGHHQHH HHSHPYSTSG INTPATASTS SSSGNSLTPQ QQQQQQHPHH
     QSHHGHHYAH HQQHTHHHAP PHSHHPHPHP HGHPHSYPHL RHSQPASASQ FSFNPSPGSS
     PGNGLGLGAR QDAASALNSP TTIVNSGSGS GGGSSVAFGM QPQQQQQSLA GGGGGGSSAT
     AAPSSGGGHN NGAGLGPVVG GGGGGLNLLG GLGGMGGMGG GAAAAGMGIC GGISSTVGSA
     AITGVPPIGL GIATGIGNKI MLGRKQSLKG GEPFLADYGP EESLNESADI EWVNKLWVRR
     LMRLCALVSL TSVSLNTPKT FERYPSLQFI TFASDTAVTL LFTAEMIAKM HIRGVLHGEV
     PYLKDHWCQF DASMVSFLWI SIILQIFEVL EIVPKFSYLS IMRAPRPLIM IRFLRVFLKF
     SMPKSRINQI FKRSSQQIYN VTLFFLFFMS LYGLLGVQFF GELKNHCVMN NTEYDLYKRP
     ILTINSLAIP DTFCSMDPDS GYQCSPGMVC MKMDFLSSYV IGFNGFEDIA TSIFTVYQAA
     SQEGWVFIMY RAIDSLPAWR AAFYFSTMIF FLAWLVKNVF IAVITETFNE IRVQFQQMWG
     ARGHIQKTAA SQILSGNDTG WRLVTIDDNK HGGLAPETCH AILRSPYFRM LVMSVILANG
     IVTATMTFKH DGRPRDVFYE RYYYIELVFT CLLDLETLFK IYCLGWRGYY KHSIHKFELL
     LAAGTTLHIV PMFYPSGLTY FQVLRVVRLI KASPMLEGFV YKIFGPGKKL GSLIIFTMCL
     LIISSSISMQ LFCFLCDFTK FESFPEAFMS MFQILTQEAW VEVMDETMIR TSKTLTPLVA
     VYFILYHLFV TLIVLSLFVA VILDNLELDE DIKKLKQLKF REQSAEIKET LPFRLRIFEK
     FPDSPQMTIL HRIPNDFMLP KVRESFMKHF VIELETEDSL VENCKRPMSE CWESNVVFRK
     QKPVRIMNKT AKVRAAGSSL RKLAITHIIN DSNNQRLMLG DSAMLPVVGT KGGGGLKSQG
     TITHSKPWRV DQKNVRSGSI KLKQTYEHLM ENGDIAAAPR ANSGRARPHD LDIKLLQAKR
     QQAEMRRNQR EEDLRENHPF FDTPLFLVPR ESRFRKICQK IVHARYDARL KDPLTGKERK
     VQYKSLHNFL GLVTYLDWVM IFATTLSCIS MMFETPNYRV MDHPTLQIAE YGFVIFMSLE
     LALKILADGL FFTPKAYIKD VAAALDVFIY VVSTSFLCWM PLNIPTNSAA QLLMILRCVR
     PLRIFTLVPH MRKVVYELCR GFKEILLVST LLILLMFIFA SYGVQLYGGR LARCNDPTIS
     RREDCVGVFM RRVFVTKMKL TPGPDESYPA MLVPRVWANP RRFNFDNIGD AMLTLFEVLS
     FKGWLDVRDV LIKAVGPVHA VYIHIYIFLG CMIGLTLFVG VVIANYSENK GTALLTVDQR
     RWCDLKKRLK IAQPLHLPPR PDGRKIRAFT YDITQHIIFK RVIAVVVLIN SMLLSITWIK
     GEVHTERLVI VSAVLTFVFV VEVVMKNIAF TPRGYWQSRR NRYDLLVTVA GVIWIILQTI
     LRNDLSYFFG FMVVILRFFT ITGKHTTLKM LMLTVGVSVC KSFFIIFGMF LLVFFYALAG
     TILFGTVKYG EGIGRRANFG SPVTGVAMLF RIVTGEDWNK IMHDCMVQPP YCTLGNNYWE
     TDCGNFTASL IYFCTFYVII TYIVLNLLVA IIMENFSLFY SNEEDALLSY ADIRNFQNTW
     NIVDIHQRGV IPVRRVKFIL RLLKGRLECD PQKDRLLFKY MCYELDKLHN GEDVTFHDVI
     NMLSYRSVDI RKALQLEELL AREEFEYLVE EEVAKMTIRT WLEGCLKKIR AQNASKQQNS
     LIAGLRATNE QPVMRPNIQE DKAPLGAVDK SAISTISGAV AGACPPTSDA FSPTFSSTEN
     EEKDGSSSAV VQLPHSETSI AGTGSSATGA ATATGTSSGL GVGPPTVQST ARHVMTVGKR
     GYALNRSDST GSSAGRKFLA PTSSDPQQRS TLSDKERLHI TSQQRKKNSM TTLPHAGQLG
     QLAKQRGGGG EATKSSSFFA QLNSEIGQFH YPTINAAAAA AALHGYGHGH GHGHGGHGGH
     GGHGEHQMHH HHGGALGSPS AMMSQMIGGS GKLLPFNNQA NAVYEVHDWW QEQVLCPQTS
     DDEI
//
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