ID R9S2C1_IXOSC Unreviewed; 250 AA.
AC R9S2C1;
DT 18-SEP-2013, integrated into UniProtKB/TrEMBL.
DT 18-SEP-2013, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE SubName: Full=Putative GABA-gated ion channel {ECO:0000313|EMBL:AGN03797.1};
DE Flags: Fragment;
OS Ixodes scapularis (Black-legged tick) (Deer tick).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Acari;
OC Parasitiformes; Ixodida; Ixodoidea; Ixodidae; Ixodinae; Ixodes.
OX NCBI_TaxID=6945 {ECO:0000313|EMBL:AGN03797.1};
RN [1] {ECO:0000313|EMBL:AGN03797.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Wikel {ECO:0000313|EMBL:AGN03797.1};
RA Lees K., Sattelle D.B.;
RT "The cys-loop ligand-gated ion channel gene superfamily of the black-legged
RT tick, Ixodes scapularis.";
RL Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; KC710949; AGN03797.1; -; mRNA.
DR AlphaFoldDB; R9S2C1; -.
DR VEuPathDB; VectorBase:ISCI022712; -.
DR VEuPathDB; VectorBase:ISCP_008020; -.
DR VEuPathDB; VectorBase:ISCW022712; -.
DR HOGENOM; CLU_010920_3_1_1; -.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0005254; F:chloride channel activity; IEA:UniProt.
DR GO; GO:0005230; F:extracellular ligand-gated monoatomic ion channel activity; IEA:InterPro.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR Gene3D; 2.70.170.10; Neurotransmitter-gated ion-channel ligand-binding domain; 1.
DR Gene3D; 1.20.58.390; Neurotransmitter-gated ion-channel transmembrane domain; 1.
DR InterPro; IPR006028; GABAA/Glycine_rcpt.
DR InterPro; IPR036734; Neur_chan_lig-bd_sf.
DR InterPro; IPR006201; Neur_channel.
DR InterPro; IPR036719; Neuro-gated_channel_TM_sf.
DR InterPro; IPR038050; Neuro_actylchol_rec.
DR InterPro; IPR006029; Neurotrans-gated_channel_TM.
DR PANTHER; PTHR18945:SF898; GLUTAMATE-GATED CHLORIDE CHANNEL; 1.
DR PANTHER; PTHR18945; NEUROTRANSMITTER GATED ION CHANNEL; 1.
DR Pfam; PF02932; Neur_chan_memb; 1.
DR PRINTS; PR00253; GABAARECEPTR.
DR SUPFAM; SSF90112; Neurotransmitter-gated ion-channel transmembrane pore; 1.
PE 2: Evidence at transcript level;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 173..193
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 205..225
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 180..249
FT /note="Neurotransmitter-gated ion-channel transmembrane"
FT /evidence="ECO:0000259|Pfam:PF02932"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:AGN03797.1"
FT NON_TER 250
FT /evidence="ECO:0000313|EMBL:AGN03797.1"
SQ SEQUENCE 250 AA; 27584 MW; 638C51F8B78DC6AF CRC64;
WVTFLWKDPR LNLKALRTYD PPIPVLPDHL AKGIWQPTVS FDRAGDAVAF DPADIFIRSD
GYLLSLRRIN FHVHCFHEGS DTGLDSQPES GSTVCDFLIR LLYEADCNCA LIWVGDKVSP
FYGVLESVVR RPEARPLVSV LVAVEPSSST KSGGTPGSNE TIFATFKFVR TSWSFLTSAY
LPSTLTVVVS WMSFWVDVGA TSSRLTLGIA CLLAITVQTG LGRIANPFGS QVRPGDMYTF
MSTMMIFLTV
//
