ID REX2_ENTFA Reviewed; 215 AA.
AC Q82ZW4;
DT 16-FEB-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 27-MAR-2024, entry version 115.
DE RecName: Full=Redox-sensing transcriptional repressor Rex 2 {ECO:0000255|HAMAP-Rule:MF_01131};
GN Name=rex2 {ECO:0000255|HAMAP-Rule:MF_01131}; OrderedLocusNames=EF_2933;
OS Enterococcus faecalis (strain ATCC 700802 / V583).
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Enterococcaceae;
OC Enterococcus.
OX NCBI_TaxID=226185;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700802 / V583;
RX PubMed=12663927; DOI=10.1126/science.1080613;
RA Paulsen I.T., Banerjei L., Myers G.S.A., Nelson K.E., Seshadri R.,
RA Read T.D., Fouts D.E., Eisen J.A., Gill S.R., Heidelberg J.F., Tettelin H.,
RA Dodson R.J., Umayam L.A., Brinkac L.M., Beanan M.J., Daugherty S.C.,
RA DeBoy R.T., Durkin S.A., Kolonay J.F., Madupu R., Nelson W.C.,
RA Vamathevan J.J., Tran B., Upton J., Hansen T., Shetty J., Khouri H.M.,
RA Utterback T.R., Radune D., Ketchum K.A., Dougherty B.A., Fraser C.M.;
RT "Role of mobile DNA in the evolution of vancomycin-resistant Enterococcus
RT faecalis.";
RL Science 299:2071-2074(2003).
CC -!- FUNCTION: Modulates transcription in response to changes in cellular
CC NADH/NAD(+) redox state. {ECO:0000255|HAMAP-Rule:MF_01131}.
CC -!- SUBUNIT: Homodimer. {ECO:0000255|HAMAP-Rule:MF_01131}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01131}.
CC -!- SIMILARITY: Belongs to the transcriptional regulatory Rex family.
CC {ECO:0000255|HAMAP-Rule:MF_01131}.
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DR EMBL; AE016830; AAO82621.1; -; Genomic_DNA.
DR RefSeq; NP_816551.1; NC_004668.1.
DR RefSeq; WP_002365189.1; NZ_KE136524.1.
DR AlphaFoldDB; Q82ZW4; -.
DR SMR; Q82ZW4; -.
DR STRING; 226185.EF_2933; -.
DR EnsemblBacteria; AAO82621; AAO82621; EF_2933.
DR GeneID; 60894857; -.
DR KEGG; efa:EF2933; -.
DR PATRIC; fig|226185.45.peg.642; -.
DR eggNOG; COG2344; Bacteria.
DR HOGENOM; CLU_061534_1_1_9; -.
DR Proteomes; UP000001415; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0045892; P:negative regulation of DNA-templated transcription; IEA:InterPro.
DR GO; GO:0051775; P:response to redox state; IEA:InterPro.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR HAMAP; MF_01131; Rex; 1.
DR InterPro; IPR003781; CoA-bd.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR009718; Rex_DNA-bd_C_dom.
DR InterPro; IPR022876; Tscrpt_rep_Rex.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR35786; REDOX-SENSING TRANSCRIPTIONAL REPRESSOR REX; 1.
DR PANTHER; PTHR35786:SF1; REDOX-SENSING TRANSCRIPTIONAL REPRESSOR REX; 1.
DR Pfam; PF02629; CoA_binding; 1.
DR Pfam; PF06971; Put_DNA-bind_N; 1.
DR SMART; SM00881; CoA_binding; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
PE 3: Inferred from homology;
KW Cytoplasm; DNA-binding; NAD; Reference proteome; Repressor; Transcription;
KW Transcription regulation.
FT CHAIN 1..215
FT /note="Redox-sensing transcriptional repressor Rex 2"
FT /id="PRO_0000097892"
FT DNA_BIND 15..54
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01131"
FT BINDING 89..94
FT /ligand="NAD(+)"
FT /ligand_id="ChEBI:CHEBI:57540"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01131"
SQ SEQUENCE 215 AA; 23920 MW; B6934FF718A6F4CD CRC64;
MEKKMPKATA KRLPVYLRYL KMLGDSGVKR IKSREFSEMI QIPSATIRRD FSHVGELGRS
GYGYDVPYLI EVFSNILNTQ EEKRIALIGC GNLGKALLKN NFRRNENLNI VCAFDNDSAL
VGTTINGLLV HDMSELEAFV RQEGVTVAIS TVPSHHAQKA IDKIVQAGVT AILNFAPDRV
SVPANVSVQY IDLTTELQTL IYFNETFSLA NSPKQ
//
