ID RL21_RAT Reviewed; 160 AA.
AC P20280;
DT 01-FEB-1991, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 3.
DT 24-JAN-2024, entry version 145.
DE RecName: Full=Large ribosomal subunit protein eL21 {ECO:0000305};
DE AltName: Full=60S ribosomal protein L21;
GN Name=Rpl21;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND PARTIAL PROTEIN SEQUENCE.
RC STRAIN=Sprague-Dawley; TISSUE=Liver;
RX PubMed=2751657; DOI=10.1016/0006-291x(89)92005-6;
RA Devi K.R.G., Chan Y.-L., Wool I.G.;
RT "The primary structure of rat ribosomal protein L21.";
RL Biochem. Biophys. Res. Commun. 162:364-370(1989).
CC -!- FUNCTION: Component of the large ribosomal subunit. The ribosome is a
CC large ribonucleoprotein complex responsible for the synthesis of
CC proteins in the cell. {ECO:0000250|UniProtKB:P46778}.
CC -!- SUBUNIT: Component of the large ribosomal subunit.
CC {ECO:0000250|UniProtKB:P46778}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC {ECO:0000250|UniProtKB:P46778}. Cytoplasm
CC {ECO:0000250|UniProtKB:P46778}. Endoplasmic reticulum
CC {ECO:0000250|UniProtKB:P49666}. Note=Detected on cytosolic polysomes
CC (By similarity). Detected in ribosomes that are associated with the
CC rough endoplasmic reticulum (By similarity).
CC {ECO:0000250|UniProtKB:P46778, ECO:0000250|UniProtKB:P49666}.
CC -!- SIMILARITY: Belongs to the eukaryotic ribosomal protein eL21 family.
CC {ECO:0000305}.
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DR EMBL; M27905; AAA41504.1; -; mRNA.
DR EMBL; X15216; CAA33286.1; -; mRNA.
DR PIR; A33295; R5RT21.
DR RefSeq; NP_445782.1; NM_053330.1.
DR AlphaFoldDB; P20280; -.
DR SMR; P20280; -.
DR BioGRID; 249469; 1.
DR STRING; 10116.ENSRNOP00000001265; -.
DR iPTMnet; P20280; -.
DR PhosphoSitePlus; P20280; -.
DR SwissPalm; P20280; -.
DR jPOST; P20280; -.
DR PaxDb; 10116-ENSRNOP00000001265; -.
DR GeneID; 79449; -.
DR KEGG; rno:79449; -.
DR AGR; RGD:68390; -.
DR CTD; 6144; -.
DR RGD; 68390; Rpl21.
DR eggNOG; KOG1732; Eukaryota.
DR InParanoid; P20280; -.
DR OrthoDB; 2906608at2759; -.
DR PhylomeDB; P20280; -.
DR PRO; PR:P20280; -.
DR Proteomes; UP000002494; Unplaced.
DR GO; GO:0005737; C:cytoplasm; ISO:RGD.
DR GO; GO:0022625; C:cytosolic large ribosomal subunit; IDA:RGD.
DR GO; GO:0022626; C:cytosolic ribosome; ISO:RGD.
DR GO; GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.
DR GO; GO:0005840; C:ribosome; IDA:RGD.
DR GO; GO:0045202; C:synapse; ISO:RGD.
DR GO; GO:0003735; F:structural constituent of ribosome; ISO:RGD.
DR GO; GO:0006412; P:translation; IEA:InterPro.
DR Gene3D; 6.10.250.3260; -; 1.
DR Gene3D; 2.30.30.70; Ribosomal protein L21; 1.
DR InterPro; IPR001147; Ribosomal_eL21.
DR InterPro; IPR018259; Ribosomal_eL21_CS.
DR InterPro; IPR036948; Ribosomal_eL21_sf.
DR InterPro; IPR008991; Translation_prot_SH3-like_sf.
DR PANTHER; PTHR20981; 60S RIBOSOMAL PROTEIN L21; 1.
DR PANTHER; PTHR20981:SF8; 60S RIBOSOMAL PROTEIN L21; 1.
DR Pfam; PF01157; Ribosomal_L21e; 1.
DR SUPFAM; SSF50104; Translation proteins SH3-like domain; 1.
DR PROSITE; PS01171; RIBOSOMAL_L21E; 1.
PE 1: Evidence at protein level;
KW Cytoplasm; Direct protein sequencing; Endoplasmic reticulum;
KW Reference proteome; Ribonucleoprotein; Ribosomal protein.
FT CHAIN 1..160
FT /note="Large ribosomal subunit protein eL21"
FT /id="PRO_0000149672"
FT REGION 112..146
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 160 AA; 18466 MW; 68F265B18EAFB876 CRC64;
MTNTKGKRRG TRYMFSRPFR KHGVVPLATY MRIYKKGDIV DIKGMGTVQK GMPHKCYHGK
TGRVYNVTQH AVGIIVNKQV KGKILAKRIN VRIEHIKHSK SRDSFLKRVK ENDQKKKEAK
EKGTWVQLNG QPAPPREAHF VRTNGKEPEL LEPIPYEFMA
//
