ID RM50_MOUSE Reviewed; 159 AA.
AC Q8VDT9; Q9CR44;
DT 28-NOV-2006, integrated into UniProtKB/Swiss-Prot.
DT 28-NOV-2006, sequence version 2.
DT 27-MAR-2024, entry version 128.
DE RecName: Full=Large ribosomal subunit protein mL50 {ECO:0000305};
DE AltName: Full=39S ribosomal protein L50, mitochondrial;
DE Short=L50mt;
DE Short=MRP-L50;
GN Name=Mrpl50;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Embryo, Forelimb, Kidney, and Pancreas;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Czech II; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Brown adipose tissue, Heart, Kidney, Liver, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- SUBUNIT: Component of the mitochondrial ribosome large subunit (39S)
CC which comprises a 16S rRNA and about 50 distinct proteins.
CC {ECO:0000250|UniProtKB:Q8N5N7}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250|UniProtKB:Q8N5N7}.
CC -!- SIMILARITY: Belongs to the mitochondrion-specific ribosomal protein
CC mL50 family. {ECO:0000305}.
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DR EMBL; AK002646; BAB22257.1; -; mRNA.
DR EMBL; AK002686; BAB22283.1; -; mRNA.
DR EMBL; AK007405; BAB25017.1; -; mRNA.
DR EMBL; AK031229; BAC27309.1; -; mRNA.
DR EMBL; AK049421; BAC33745.1; -; mRNA.
DR EMBL; AK075787; BAC35958.1; -; mRNA.
DR EMBL; BC021318; AAH21318.1; -; mRNA.
DR CCDS; CCDS18174.1; -.
DR RefSeq; NP_848718.1; NM_178603.4.
DR AlphaFoldDB; Q8VDT9; -.
DR SMR; Q8VDT9; -.
DR BioGRID; 205724; 12.
DR ComplexPortal; CPX-5302; 39S mitochondrial large ribosomal subunit.
DR STRING; 10090.ENSMUSP00000062476; -.
DR PhosphoSitePlus; Q8VDT9; -.
DR EPD; Q8VDT9; -.
DR MaxQB; Q8VDT9; -.
DR PaxDb; 10090-ENSMUSP00000062476; -.
DR PeptideAtlas; Q8VDT9; -.
DR ProteomicsDB; 301606; -.
DR Pumba; Q8VDT9; -.
DR Antibodypedia; 14646; 166 antibodies from 24 providers.
DR DNASU; 28028; -.
DR Ensembl; ENSMUST00000057829.4; ENSMUSP00000062476.4; ENSMUSG00000044018.4.
DR GeneID; 28028; -.
DR KEGG; mmu:28028; -.
DR UCSC; uc008svu.1; mouse.
DR AGR; MGI:107329; -.
DR CTD; 54534; -.
DR MGI; MGI:107329; Mrpl50.
DR VEuPathDB; HostDB:ENSMUSG00000044018; -.
DR eggNOG; ENOG502S27V; Eukaryota.
DR GeneTree; ENSGT00390000004279; -.
DR HOGENOM; CLU_137129_0_0_1; -.
DR InParanoid; Q8VDT9; -.
DR OMA; LMCSAQD; -.
DR OrthoDB; 2902137at2759; -.
DR PhylomeDB; Q8VDT9; -.
DR TreeFam; TF105895; -.
DR Reactome; R-MMU-5389840; Mitochondrial translation elongation.
DR Reactome; R-MMU-5419276; Mitochondrial translation termination.
DR BioGRID-ORCS; 28028; 18 hits in 79 CRISPR screens.
DR ChiTaRS; Mrpl50; mouse.
DR PRO; PR:Q8VDT9; -.
DR Proteomes; UP000000589; Chromosome 4.
DR RNAct; Q8VDT9; Protein.
DR Bgee; ENSMUSG00000044018; Expressed in heart right ventricle and 266 other cell types or tissues.
DR Genevisible; Q8VDT9; MM.
DR GO; GO:0005829; C:cytosol; ISO:MGI.
DR GO; GO:0005743; C:mitochondrial inner membrane; NAS:ComplexPortal.
DR GO; GO:0005762; C:mitochondrial large ribosomal subunit; ISS:UniProtKB.
DR GO; GO:0005739; C:mitochondrion; HDA:MGI.
DR GO; GO:0032543; P:mitochondrial translation; NAS:ComplexPortal.
DR InterPro; IPR018305; Ribosomal_m50.
DR PANTHER; PTHR31542; 39A RIBOSOMAL PROTEIN L50, MITOCHONDRIAL; 1.
DR PANTHER; PTHR31542:SF1; 39S RIBOSOMAL PROTEIN L50, MITOCHONDRIAL; 1.
DR Pfam; PF10501; Ribosomal_L50; 1.
PE 1: Evidence at protein level;
KW Mitochondrion; Reference proteome; Ribonucleoprotein; Ribosomal protein.
FT CHAIN 1..159
FT /note="Large ribosomal subunit protein mL50"
FT /id="PRO_0000261660"
FT CONFLICT 5
FT /note="I -> V (in Ref. 2; AAH21318)"
FT /evidence="ECO:0000305"
FT CONFLICT 9
FT /note="L -> F (in Ref. 2; AAH21318)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 159 AA; 18213 MW; 241C20AB55204364 CRC64;
MAALIVSRLA RRGWLWKLPL ATRREFWSRS RKEKEPVVAE TVEEVKKEPV LVCPPLRSRA
YTPPSDLQSR LESHIKEVLG SSLPNNWQDI SLDDGHMKFR LLAGLADGLG HAVPNSRLHQ
MCRVRDVLDF YNVPVQDKSK FDELVASNLP PNLKISWSY
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