ID RN225_HUMAN Reviewed; 329 AA.
AC M0QZC1;
DT 26-NOV-2014, integrated into UniProtKB/Swiss-Prot.
DT 29-OCT-2014, sequence version 2.
DT 24-JAN-2024, entry version 57.
DE RecName: Full=RING finger protein 225 {ECO:0000312|HGNC:HGNC:51249};
GN Name=RNF225 {ECO:0000312|HGNC:HGNC:51249};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057824; DOI=10.1038/nature02399;
RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA Rubin E.M., Lucas S.M.;
RT "The DNA sequence and biology of human chromosome 19.";
RL Nature 428:529-535(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Single-pass membrane
CC protein {ECO:0000255}.
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DR EMBL; AC012313; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471135; EAW72584.1; -; Genomic_DNA.
DR CCDS; CCDS74477.1; -.
DR RefSeq; NP_001182064.1; NM_001195135.1.
DR RefSeq; XP_006723391.1; XM_006723328.3.
DR AlphaFoldDB; M0QZC1; -.
DR STRING; 9606.ENSP00000470441; -.
DR iPTMnet; M0QZC1; -.
DR PhosphoSitePlus; M0QZC1; -.
DR BioMuta; RNF225; -.
DR MassIVE; M0QZC1; -.
DR PaxDb; 9606-ENSP00000470441; -.
DR PeptideAtlas; M0QZC1; -.
DR DNASU; 646862; -.
DR Ensembl; ENST00000601382.3; ENSP00000470441.2; ENSG00000269855.3.
DR GeneID; 646862; -.
DR KEGG; hsa:646862; -.
DR MANE-Select; ENST00000601382.3; ENSP00000470441.2; NM_001195135.2; NP_001182064.1.
DR UCSC; uc021vcz.1; human.
DR AGR; HGNC:51249; -.
DR CTD; 646862; -.
DR GeneCards; RNF225; -.
DR HGNC; HGNC:51249; RNF225.
DR HPA; ENSG00000269855; Tissue enhanced (cervix, esophagus, skin, vagina).
DR neXtProt; NX_M0QZC1; -.
DR OpenTargets; ENSG00000269855; -.
DR VEuPathDB; HostDB:ENSG00000269855; -.
DR eggNOG; KOG2177; Eukaryota.
DR GeneTree; ENSGT00940000163974; -.
DR HOGENOM; CLU_1013832_0_0_1; -.
DR InParanoid; M0QZC1; -.
DR OMA; WVFNAAV; -.
DR OrthoDB; 7576at2759; -.
DR SIGNOR; M0QZC1; -.
DR BioGRID-ORCS; 646862; 11 hits in 236 CRISPR screens.
DR GenomeRNAi; 646862; -.
DR Pharos; M0QZC1; Tdark.
DR PRO; PR:M0QZC1; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; M0QZC1; Protein.
DR Bgee; ENSG00000269855; Expressed in esophagus mucosa and 27 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0061630; F:ubiquitin protein ligase activity; IBA:GO_Central.
DR GO; GO:0016567; P:protein ubiquitination; IBA:GO_Central.
DR CDD; cd16556; RING-HC_RNF183-like; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR027370; Znf-RING_euk.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR017907; Znf_RING_CS.
DR PANTHER; PTHR22791:SF1; RING FINGER PROTEIN 225; 1.
DR PANTHER; PTHR22791; UNCHARACTERIZED; 1.
DR Pfam; PF13445; zf-RING_UBOX; 1.
DR SMART; SM00184; RING; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR PROSITE; PS00518; ZF_RING_1; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 3: Inferred from homology;
KW Membrane; Metal-binding; Reference proteome; Transmembrane;
KW Transmembrane helix; Zinc; Zinc-finger.
FT CHAIN 1..329
FT /note="RING finger protein 225"
FT /id="PRO_0000431309"
FT TRANSMEM 203..223
FT /note="Helical"
FT /evidence="ECO:0000255"
FT ZN_FING 64..112
FT /note="RING-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00175"
FT REGION 1..55
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 122..181
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 248..329
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 15..32
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 157..181
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 248..264
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 290..304
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 329 AA; 34789 MW; 32B366C4EF36284D CRC64;
MPCPRPFWLR HSRAPQGSGP SSPGSLSAPR SPSRGEDQEE EEEEEGDGSP GSGPILPPAS
PVECLICVSS FDGVFKLPKR LDCGHVFCLE CLARLSLATA GGGNAVACPV CRAPTRLAPR
RGLPALPTQS GLLPRDARAP PSRQGSVRFD RRRGLLYLRP PPPPPGPRKA RAPPPPPPLR
LGRPLSRRLS LASPAWVFNA AVALAVLVAA GLVVSGVYIF FLIPHATSSG PPRPQLVALA
PAPGFSWFPP RPPPGSPWAP AWTPRPTGPD LDTALPGTAE DALEPEAGPE DPAEAERTLD
RRSDGTWGTE AGPGWAPWPR GARRLWGSQ
//
