ID RPA43_MOUSE Reviewed; 330 AA.
AC Q78WZ7; Q3U6L1; Q8CEP7; Q9CS60;
DT 29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 27-MAR-2024, entry version 139.
DE RecName: Full=DNA-directed RNA polymerase I subunit RPA43;
DE AltName: Full=DNA-directed RNA polymerase I subunit F {ECO:0000250|UniProtKB:Q3B726};
DE AltName: Full=Twist neighbor protein {ECO:0000303|PubMed:12438708};
GN Name=Polr1f {ECO:0000250|UniProtKB:Q3B726};
GN Synonyms=Twistnb {ECO:0000303|PubMed:12438708};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Bone marrow, and Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP TISSUE SPECIFICITY.
RX PubMed=12438708; DOI=10.1159/000066618;
RA Kosan C., Kunz J.;
RT "Identification and characterisation of the gene TWIST NEIGHBOR (TWISTNB)
RT located in the microdeletion syndrome 7p21 region.";
RL Cytogenet. Genome Res. 97:167-170(2002).
RN [3]
RP INTERACTION WITH RRN3.
RX PubMed=12393749; DOI=10.1093/embo-reports/kvf212;
RA Yuan X., Zhao J., Zentgraf H., Hoffmann-Rohrer U., Grummt I.;
RT "Multiple interactions between RNA polymerase I, TIF-IA and TAF(I) subunits
RT regulate preinitiation complex assembly at the ribosomal gene promoter.";
RL EMBO Rep. 3:1082-1087(2002).
CC -!- FUNCTION: Component of RNA polymerase I (Pol I), a DNA-dependent RNA
CC polymerase which synthesizes ribosomal RNA precursors using the four
CC ribonucleoside triphosphates as substrates. Through its association
CC with RRN3/TIF-IA may be involved in recruitment of Pol I to rDNA
CC promoters. {ECO:0000250|UniProtKB:Q3B726}.
CC -!- SUBUNIT: Component of the RNA polymerase I (Pol I) complex consisting
CC of 13 subunits: a ten-subunit catalytic core composed of POLR1A/RPA1,
CC POLR1B/RPA2, POLR1C/RPAC1, POLR1D/RPAC2, POLR1H/RPA12, POLR2E/RPABC1,
CC POLR2F/RPABC2, POLR2H/RPABC3, POLR2K/RPABC4 and POLR2L/RPABC5; a mobile
CC stalk subunit POLR1F/RPA43 protruding from the core and additional
CC subunits homologous to general transcription factors POLR1E/RPA49 and
CC POLR1G/RPA34 (By similarity). Interacts with RRN3/TIF-IA. Interacts
CC with RRN3/TIF-IA. {ECO:0000250, ECO:0000250|UniProtKB:Q3B726,
CC ECO:0000269|PubMed:12393749}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC {ECO:0000250|UniProtKB:Q3B726}.
CC -!- TISSUE SPECIFICITY: Widely expressed. {ECO:0000269|PubMed:12438708}.
CC -!- SIMILARITY: Belongs to the eukaryotic RPA43 RNA polymerase subunit
CC family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC25502.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AK010829; BAB27210.1; -; mRNA.
DR EMBL; AK017810; BAB30947.1; -; mRNA.
DR EMBL; AK017016; BAC25502.1; ALT_FRAME; mRNA.
DR EMBL; AK153090; BAE31713.1; -; mRNA.
DR CCDS; CCDS25877.1; -.
DR RefSeq; NP_758457.1; NM_172253.2.
DR AlphaFoldDB; Q78WZ7; -.
DR SMR; Q78WZ7; -.
DR BioGRID; 205748; 1.
DR STRING; 10090.ENSMUSP00000020877; -.
DR iPTMnet; Q78WZ7; -.
DR PhosphoSitePlus; Q78WZ7; -.
DR EPD; Q78WZ7; -.
DR jPOST; Q78WZ7; -.
DR MaxQB; Q78WZ7; -.
DR PaxDb; 10090-ENSMUSP00000020877; -.
DR ProteomicsDB; 262699; -.
DR Pumba; Q78WZ7; -.
DR Antibodypedia; 11907; 102 antibodies from 21 providers.
DR DNASU; 28071; -.
DR Ensembl; ENSMUST00000020877.9; ENSMUSP00000020877.8; ENSMUSG00000020561.9.
DR GeneID; 28071; -.
DR KEGG; mmu:28071; -.
DR UCSC; uc007niu.1; mouse.
DR AGR; MGI:106292; -.
DR CTD; 221830; -.
DR MGI; MGI:106292; Polr1f.
DR VEuPathDB; HostDB:ENSMUSG00000020561; -.
DR eggNOG; KOG4134; Eukaryota.
DR GeneTree; ENSGT00390000005553; -.
DR HOGENOM; CLU_048289_0_0_1; -.
DR InParanoid; Q78WZ7; -.
DR OMA; EQWHTVE; -.
DR OrthoDB; 3151756at2759; -.
DR PhylomeDB; Q78WZ7; -.
DR TreeFam; TF325602; -.
DR Reactome; R-MMU-5250924; B-WICH complex positively regulates rRNA expression.
DR Reactome; R-MMU-73762; RNA Polymerase I Transcription Initiation.
DR Reactome; R-MMU-73772; RNA Polymerase I Promoter Escape.
DR Reactome; R-MMU-73863; RNA Polymerase I Transcription Termination.
DR BioGRID-ORCS; 28071; 26 hits in 77 CRISPR screens.
DR PRO; PR:Q78WZ7; -.
DR Proteomes; UP000000589; Chromosome 12.
DR RNAct; Q78WZ7; Protein.
DR Bgee; ENSMUSG00000020561; Expressed in manus and 231 other cell types or tissues.
DR ExpressionAtlas; Q78WZ7; baseline and differential.
DR Genevisible; Q78WZ7; MM.
DR GO; GO:0005736; C:RNA polymerase I complex; IBA:GO_Central.
DR GO; GO:1990830; P:cellular response to leukemia inhibitory factor; IEP:MGI.
DR GO; GO:0006352; P:DNA-templated transcription initiation; IEA:InterPro.
DR CDD; cd04328; RNAP_I_Rpa43_N; 1.
DR Gene3D; 2.40.50.1060; -; 1.
DR Gene3D; 3.30.1490.120; RNA polymerase Rpb7-like, N-terminal domain; 1.
DR InterPro; IPR036898; RNA_pol_Rpb7-like_N_sf.
DR InterPro; IPR041901; RNAP_I_Rpa43_N.
DR InterPro; IPR041178; RPA43_OB.
DR InterPro; IPR045113; Rpb7-like.
DR InterPro; IPR005576; Rpb7-like_N.
DR PANTHER; PTHR12709:SF5; DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA43; 1.
DR PANTHER; PTHR12709; DNA-DIRECTED RNA POLYMERASE II, III; 1.
DR Pfam; PF17875; RPA43_OB; 1.
DR Pfam; PF03876; SHS2_Rpb7-N; 1.
PE 1: Evidence at protein level;
KW DNA-directed RNA polymerase; Nucleus; Phosphoprotein; Reference proteome;
KW Transcription.
FT CHAIN 1..330
FT /note="DNA-directed RNA polymerase I subunit RPA43"
FT /id="PRO_0000288633"
FT REGION 251..330
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 251..266
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 306
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q3B726"
FT MOD_RES 318
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q3B726"
FT MOD_RES 325
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q3B726"
FT CONFLICT 124
FT /note="C -> S (in Ref. 1; BAE31713)"
FT /evidence="ECO:0000305"
FT CONFLICT 134
FT /note="T -> I (in Ref. 1; BAC25502)"
FT /evidence="ECO:0000305"
FT CONFLICT 225
FT /note="K -> N (in Ref. 1; BAC25502)"
FT /evidence="ECO:0000305"
FT CONFLICT 259
FT /note="Q -> R (in Ref. 1; BAC25502)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 330 AA; 36721 MW; C68996895950DA73 CRC64;
MAAGSVESQR SQAASERPVA GQAGVLPCLE LPSYAAACAL VGSRYSCLVA APHRRHIALS
PRYLSRKRTG IREQLDAELL RYSESLLGVP IAYDNIRVVG ELGDIYDDQG HIHLNIEADF
VIFCPEPGQT LMGTVNKVSS SHIGCLVHGC FNASIPKPEQ MSYEEWQTLE IHVGDELEFD
VFRLDSDSAG VFCIRGKLST TSLQLKHSAV SEDVAETVVE EVVEKTPKKK KKKKDKDTDT
CGTVDSVTEV ADVTDVTPQE ETDIPCSDNV NDFFEEEPKK KKKKKKRHQE DQDPIFQASD
SSGYQSDHNK KKKKRKHSEE ANFESPKKRQ
//