ID RPAR_RHOPA Reviewed; 243 AA.
AC Q6NCZ5;
DT 29-OCT-2014, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 27-MAR-2024, entry version 114.
DE RecName: Full=HTH-type quorum sensing-dependent transcriptional regulator RpaR {ECO:0000305};
DE AltName: Full=4-coumaroyl-homoserine lactone receptor {ECO:0000305};
DE Short=pC-HSL receptor {ECO:0000303|PubMed:18563084};
GN Name=rpaR {ECO:0000303|PubMed:18563084};
GN OrderedLocusNames=RPA0321 {ECO:0000312|EMBL:CAE25765.1};
OS Rhodopseudomonas palustris (strain ATCC BAA-98 / CGA009).
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Hyphomicrobiales;
OC Nitrobacteraceae; Rhodopseudomonas.
OX NCBI_TaxID=258594;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-98 / CGA009;
RX PubMed=14704707; DOI=10.1038/nbt923;
RA Larimer F.W., Chain P., Hauser L., Lamerdin J.E., Malfatti S., Do L.,
RA Land M.L., Pelletier D.A., Beatty J.T., Lang A.S., Tabita F.R.,
RA Gibson J.L., Hanson T.E., Bobst C., Torres y Torres J.L., Peres C.,
RA Harrison F.H., Gibson J., Harwood C.S.;
RT "Complete genome sequence of the metabolically versatile photosynthetic
RT bacterium Rhodopseudomonas palustris.";
RL Nat. Biotechnol. 22:55-61(2004).
RN [2]
RP FUNCTION IN QUORUM-SENSING.
RC STRAIN=ATCC BAA-98 / CGA009;
RX PubMed=18563084; DOI=10.1038/nature07088;
RA Schaefer A.L., Greenberg E.P., Oliver C.M., Oda Y., Huang J.J.,
RA Bittan-Banin G., Peres C.M., Schmidt S., Juhaszova K., Sufrin J.R.,
RA Harwood C.S.;
RT "A new class of homoserine lactone quorum-sensing signals.";
RL Nature 454:595-599(2008).
CC -!- FUNCTION: Responds to the quorum-sensing autoinducer 4-coumaroyl-
CC homoserine lactone to regulate expression of several genes. Represses
CC expression of rpaI in the absence of the inducer.
CC {ECO:0000269|PubMed:18563084}.
CC -!- SIMILARITY: Belongs to the autoinducer-regulated transcriptional
CC regulatory protein family. {ECO:0000305}.
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DR EMBL; BX572594; CAE25765.1; -; Genomic_DNA.
DR RefSeq; WP_011155889.1; NZ_CP116810.1.
DR AlphaFoldDB; Q6NCZ5; -.
DR SMR; Q6NCZ5; -.
DR STRING; 258594.RPA0321; -.
DR DNASU; 2689487; -.
DR GeneID; 66891331; -.
DR eggNOG; COG2197; Bacteria.
DR HOGENOM; CLU_072786_4_1_5; -.
DR PhylomeDB; Q6NCZ5; -.
DR Proteomes; UP000001426; Chromosome.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0009372; P:quorum sensing; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd06170; LuxR_C_like; 1.
DR Gene3D; 3.30.450.80; Transcription factor LuxR-like, autoinducer-binding domain; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR016032; Sig_transdc_resp-reg_C-effctor.
DR InterPro; IPR005143; TF_LuxR_autoind-bd_dom.
DR InterPro; IPR036693; TF_LuxR_autoind-bd_dom_sf.
DR InterPro; IPR000792; Tscrpt_reg_LuxR_C.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR44688; -; 1.
DR PANTHER; PTHR44688:SF16; TRANSCRIPTIONAL ACTIVATOR PROTEIN BJAR1; 1.
DR Pfam; PF03472; Autoind_bind; 1.
DR Pfam; PF00196; GerE; 1.
DR PRINTS; PR00038; HTHLUXR.
DR SMART; SM00421; HTH_LUXR; 1.
DR SUPFAM; SSF46894; C-terminal effector domain of the bipartite response regulators; 1.
DR SUPFAM; SSF75516; Pheromone-binding domain of LuxR-like quorum-sensing transcription factors; 1.
DR PROSITE; PS50043; HTH_LUXR_2; 1.
PE 1: Evidence at protein level;
KW DNA-binding; Quorum sensing; Reference proteome; Repressor; Transcription;
KW Transcription regulation.
FT CHAIN 1..243
FT /note="HTH-type quorum sensing-dependent transcriptional
FT regulator RpaR"
FT /id="PRO_0000430602"
FT DOMAIN 174..239
FT /note="HTH luxR-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00411"
FT DNA_BIND 198..217
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00411"
SQ SEQUENCE 243 AA; 26938 MW; 2C3950162EC4D16C CRC64;
MIVGEDQLWG RRALEFVDSV ERLEAPALIS RFESLIASCG FTAYIMAGLP SRNAGLPELT
LANGWPRDWF DLYVSENFSA VDPVPRHGAT TVHPFVWSDA PYDRDRDPAA HRVMTRAAEF
GLVEGYCIPL HYDDGSAAIS MAGKDPDLSP AARGAMQLVS IYAHSRLRAL SRPKPIRRNR
LTPRECEILQ WAAQGKTAWE ISVILCITER TVKFHLIEAA RKLDAANRTA AVAKALTLGL
IRL
//
