ID RPOE_STRE4 Reviewed; 188 AA.
AC C0M8K7;
DT 28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT 05-MAY-2009, sequence version 1.
DT 27-MAR-2024, entry version 73.
DE RecName: Full=Probable DNA-directed RNA polymerase subunit delta {ECO:0000255|HAMAP-Rule:MF_00357};
DE AltName: Full=RNAP delta factor {ECO:0000255|HAMAP-Rule:MF_00357};
GN Name=rpoE {ECO:0000255|HAMAP-Rule:MF_00357}; OrderedLocusNames=SEQ_1946;
OS Streptococcus equi subsp. equi (strain 4047).
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
OC Streptococcus.
OX NCBI_TaxID=553482;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=4047;
RX PubMed=19325880; DOI=10.1371/journal.ppat.1000346;
RA Holden M.T.G., Heather Z., Paillot R., Steward K.F., Webb K., Ainslie F.,
RA Jourdan T., Bason N.C., Holroyd N.E., Mungall K., Quail M.A., Sanders M.,
RA Simmonds M., Willey D., Brooks K., Aanensen D.M., Spratt B.G., Jolley K.A.,
RA Maiden M.C.J., Kehoe M., Chanter N., Bentley S.D., Robinson C.,
RA Maskell D.J., Parkhill J., Waller A.S.;
RT "Genomic evidence for the evolution of Streptococcus equi: host
RT restriction, increased virulence, and genetic exchange with human
RT pathogens.";
RL PLoS Pathog. 5:E1000346-E1000346(2009).
CC -!- FUNCTION: Participates in both the initiation and recycling phases of
CC transcription. In the presence of the delta subunit, RNAP displays an
CC increased specificity of transcription, a decreased affinity for
CC nucleic acids, and an increased efficiency of RNA synthesis because of
CC enhanced recycling. {ECO:0000255|HAMAP-Rule:MF_00357}.
CC -!- SUBUNIT: RNAP is composed of a core of 2 alpha, a beta and a beta'
CC subunits. The core is associated with a delta subunit and one of
CC several sigma factors. {ECO:0000255|HAMAP-Rule:MF_00357}.
CC -!- SIMILARITY: Belongs to the RpoE family. {ECO:0000255|HAMAP-
CC Rule:MF_00357}.
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DR EMBL; FM204883; CAW95173.1; -; Genomic_DNA.
DR RefSeq; WP_012680108.1; NC_012471.1.
DR AlphaFoldDB; C0M8K7; -.
DR SMR; C0M8K7; -.
DR KEGG; seu:SEQ_1946; -.
DR HOGENOM; CLU_116648_0_0_9; -.
DR OrthoDB; 401223at2; -.
DR Proteomes; UP000001365; Chromosome.
DR GO; GO:0000428; C:DNA-directed RNA polymerase complex; IEA:UniProtKB-KW.
DR GO; GO:0003899; F:DNA-directed 5'-3' RNA polymerase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006351; P:DNA-templated transcription; IEA:InterPro.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:UniProtKB-UniRule.
DR Gene3D; 1.10.10.1250; RNA polymerase, subunit delta, N-terminal domain; 1.
DR HAMAP; MF_00357; RNApol_bact_RpoE; 1.
DR InterPro; IPR007759; Asxl_HARE-HTH.
DR InterPro; IPR038087; RNAP_delta_N_dom_sf.
DR InterPro; IPR029757; RpoE.
DR NCBIfam; TIGR04567; RNAP_delt_lowGC; 1.
DR Pfam; PF05066; HARE-HTH; 1.
DR PROSITE; PS51913; HTH_HARE; 1.
PE 3: Inferred from homology;
KW DNA-directed RNA polymerase; Nucleotidyltransferase; Transcription;
KW Transferase.
FT CHAIN 1..188
FT /note="Probable DNA-directed RNA polymerase subunit delta"
FT /id="PRO_1000133449"
FT DOMAIN 14..83
FT /note="HTH HARE-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01261"
FT REGION 119..188
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 120..188
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 188 AA; 21921 MW; 53A93589E6C7034A CRC64;
MKLDVFAGQE ISELSMIEVA RAILEERGRD NDMYFSDLVN EIQNYLGKSD ADIRYALPFF
YTDLNTDGSF IPLGENKWGL RSWYAIDEID EEIITLEDEE DGAPKRKKKR VNAFMDGDED
AIDYSADDPE DEDFVRESSD IEYDEEDPDD EKSEVESYDS ELNEIIPEDD FEEVDLNEED
EEDEEEEE
//
