ID RPP14_PONAB Reviewed; 124 AA.
AC Q5RB79;
DT 26-APR-2005, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 3.
DT 03-MAY-2023, entry version 83.
DE RecName: Full=Ribonuclease P protein subunit p14;
GN Name=RPP14;
OS Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pongo.
OX NCBI_TaxID=9601;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Heart;
RG The German cDNA consortium;
RL Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Component of ribonuclease P, a ribonucleoprotein complex that
CC generates mature tRNA molecules by cleaving their 5'-ends.
CC {ECO:0000250|UniProtKB:O95059}.
CC -!- SUBUNIT: RNase P consists of a catalytic RNA moiety and about 10
CC protein subunits; POP1, POP4, POP5, POP7, RPP14, RPP21, RPP25, RPP30,
CC RPP38 and RPP40. Within the RNase P complex, POP1, POP7 and RPP25 form
CC the 'finger' subcomplex, POP5, RPP14, RPP40 and homodimeric RPP30 form
CC the 'palm' subcomplex, and RPP21, POP4 and RPP38 form the 'wrist'
CC subcomplex. All subunits of the RNase P complex interact with the
CC catalytic RNA. {ECO:0000250|UniProtKB:O95059}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC {ECO:0000250|UniProtKB:O95059}.
CC -!- SIMILARITY: Belongs to the eukaryotic/archaeal RNase P protein
CC component 2 family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CR858774; CAH90981.1; -; mRNA.
DR RefSeq; NP_001127358.1; NM_001133886.1.
DR RefSeq; XP_009237129.1; XM_009238854.1.
DR AlphaFoldDB; Q5RB79; -.
DR SMR; Q5RB79; -.
DR STRING; 9601.ENSPPYP00000015396; -.
DR GeneID; 100174423; -.
DR KEGG; pon:100174423; -.
DR CTD; 11102; -.
DR eggNOG; ENOG502S10S; Eukaryota.
DR HOGENOM; CLU_157358_0_0_1; -.
DR InParanoid; Q5RB79; -.
DR OrthoDB; 3108059at2759; -.
DR TreeFam; TF324711; -.
DR Proteomes; UP000001595; Chromosome 3.
DR GO; GO:0030681; C:multimeric ribonuclease P complex; ISS:UniProtKB.
DR GO; GO:0005730; C:nucleolus; ISS:UniProtKB.
DR GO; GO:0004526; F:ribonuclease P activity; IEA:UniProtKB-EC.
DR GO; GO:0033204; F:ribonuclease P RNA binding; ISS:UniProtKB.
DR GO; GO:0001682; P:tRNA 5'-leader removal; ISS:UniProtKB.
DR Gene3D; 3.30.70.3250; Ribonuclease P, Pop5 subunit; 1.
DR InterPro; IPR002759; Pop5/Rpp14/Rnp2-like.
DR InterPro; IPR038085; Rnp2-like_sf.
DR PANTHER; PTHR15441; RIBONUCLEASE P PROTEIN SUBUNIT P14; 1.
DR PANTHER; PTHR15441:SF1; RIBONUCLEASE P PROTEIN SUBUNIT P14; 1.
DR Pfam; PF01900; RNase_P_Rpp14; 1.
DR SUPFAM; SSF160350; Rnp2-like; 1.
PE 2: Evidence at transcript level;
KW Nucleus; Reference proteome; tRNA processing.
FT CHAIN 1..124
FT /note="Ribonuclease P protein subunit p14"
FT /id="PRO_0000140012"
SQ SEQUENCE 124 AA; 13693 MW; 10AF6C947785DD90 CRC64;
MPAPAATYER VVYKNPSEYH YMKVCLEFQD CGVGLNAAQF KQLLISAVKD LFGEVDAALP
LDILTYEEKT LSAILRICSS GLVKLWSSLT LLGSYKGKKC AFRVIQVSPF LLALSGNSRE
LVLD
//
