ID RRAGA_DICDI Reviewed; 301 AA.
AC Q54IK1;
DT 08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 24-JAN-2024, entry version 103.
DE RecName: Full=Ras-related GTP-binding protein A {ECO:0000305};
GN Name=ragA; ORFNames=DDB_G0288701;
OS Dictyostelium discoideum (Social amoeba).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- FUNCTION: Guanine nucleotide-binding protein that plays a crucial role
CC in the cellular response to amino acid availability through regulation
CC of the TOR signaling cascade. {ECO:0000250|UniProtKB:Q7L523}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q7L523}. Nucleus
CC {ECO:0000250|UniProtKB:Q7L523}. Lysosome
CC {ECO:0000250|UniProtKB:Q7L523}.
CC -!- SIMILARITY: Belongs to the GTR/RAG GTP-binding protein family.
CC {ECO:0000305}.
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DR EMBL; AAFI02000120; EAL63082.1; -; Genomic_DNA.
DR RefSeq; XP_636585.1; XM_631493.1.
DR AlphaFoldDB; Q54IK1; -.
DR SMR; Q54IK1; -.
DR STRING; 44689.Q54IK1; -.
DR PaxDb; 44689-DDB0230043; -.
DR EnsemblProtists; EAL63082; EAL63082; DDB_G0288701.
DR GeneID; 8626758; -.
DR KEGG; ddi:DDB_G0288701; -.
DR dictyBase; DDB_G0288701; ragA.
DR eggNOG; KOG3886; Eukaryota.
DR HOGENOM; CLU_044099_1_0_1; -.
DR InParanoid; Q54IK1; -.
DR OMA; LIPNMQD; -.
DR PhylomeDB; Q54IK1; -.
DR Reactome; R-DDI-1632852; Macroautophagy.
DR Reactome; R-DDI-165159; MTOR signalling.
DR Reactome; R-DDI-166208; mTORC1-mediated signalling.
DR Reactome; R-DDI-380972; Energy dependent regulation of mTOR by LKB1-AMPK.
DR Reactome; R-DDI-5628897; TP53 Regulates Metabolic Genes.
DR Reactome; R-DDI-8866654; E3 ubiquitin ligases ubiquitinate target proteins.
DR Reactome; R-DDI-8943724; Regulation of PTEN gene transcription.
DR Reactome; R-DDI-9639288; Amino acids regulate mTORC1.
DR PRO; PR:Q54IK1; -.
DR Proteomes; UP000002195; Chromosome 5.
DR GO; GO:1990131; C:Gtr1-Gtr2 GTPase complex; IBA:GO_Central.
DR GO; GO:0005764; C:lysosome; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IBA:GO_Central.
DR GO; GO:0009267; P:cellular response to starvation; IBA:GO_Central.
DR GO; GO:0010507; P:negative regulation of autophagy; IBA:GO_Central.
DR GO; GO:0006817; P:phosphate ion transport; ISS:dictyBase.
DR CDD; cd11384; RagA_like; 1.
DR Gene3D; 3.30.450.190; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR006762; Gtr1_RagA.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR039397; RagA/B.
DR InterPro; IPR005225; Small_GTP-bd_dom.
DR NCBIfam; TIGR00231; small_GTP; 1.
DR PANTHER; PTHR11259; RAS-RELATED GTP BINDING RAG/GTR YEAST; 1.
DR PANTHER; PTHR11259:SF1; RAS-RELATED GTP-BINDING PROTEIN; 1.
DR Pfam; PF04670; Gtr1_RagA; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 2: Evidence at transcript level;
KW Cytoplasm; GTP-binding; Lysosome; Nucleotide-binding; Nucleus;
KW Reference proteome.
FT CHAIN 1..301
FT /note="Ras-related GTP-binding protein A"
FT /id="PRO_0000327795"
FT BINDING 9..16
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250"
FT BINDING 57..61
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250"
FT BINDING 122..125
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250"
SQ SEQUENCE 301 AA; 34828 MW; D7BD3ADF30103BBB CRC64;
MKRKVLLMGR SESGKTSMRS IIFANYIARD TMRLGVTIDV EHSHVRFLGN LVLNLWDCGG
QEGFLESYLT TQRDHIFRNV EVLIYVFDIE SREHQKDIKN YKSCIEAISQ NSKDAKIFCL
IHKMDLVPED QRDTLFKNKE QEIRQASLPL KPTCFRTSIW DETLYKAWSS IVYSLIPNVK
VLEYNLDKFC KICEADEVVL FEKATFLVIS HSARKVHKDV HRFEKISTII KQFFLSCSKS
QANFQAMEVR NSNFAAFIDA FTSNTYIMVI MSDPTIESSA TLLNIQVAKS HFEKFINSTS
N
//
