ID RTC1_DEBHA Reviewed; 1386 AA.
AC Q6BXX5;
DT 31-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT 04-NOV-2008, sequence version 2.
DT 24-JAN-2024, entry version 118.
DE RecName: Full=Restriction of telomere capping protein 1;
GN Name=RTC1; OrderedLocusNames=DEHA2A14124g;
OS Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990
OS / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Debaryomyces.
OX NCBI_TaxID=284592;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968;
RX PubMed=15229592; DOI=10.1038/nature02579;
RA Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA Weissenbach J., Wincker P., Souciet J.-L.;
RT "Genome evolution in yeasts.";
RL Nature 430:35-44(2004).
CC -!- FUNCTION: May be involved in a process influencing telomere capping.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Vacuole {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the WD repeat RTC1 family. {ECO:0000305}.
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DR EMBL; CR382133; CAG84922.2; -; Genomic_DNA.
DR RefSeq; XP_456944.2; XM_456944.1.
DR AlphaFoldDB; Q6BXX5; -.
DR SMR; Q6BXX5; -.
DR STRING; 284592.Q6BXX5; -.
DR GeneID; 2899395; -.
DR KEGG; dha:DEHA2A14124g; -.
DR VEuPathDB; FungiDB:DEHA2A14124g; -.
DR eggNOG; KOG0269; Eukaryota.
DR HOGENOM; CLU_008512_0_0_1; -.
DR InParanoid; Q6BXX5; -.
DR OMA; GRDGKCC; -.
DR OrthoDB; 119005at2759; -.
DR Proteomes; UP000000599; Chromosome A.
DR GO; GO:0005773; C:vacuole; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0032008; P:positive regulation of TOR signaling; IEA:InterPro.
DR CDD; cd16488; mRING-H2-C3H3C2_Mio-like; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR InterPro; IPR037590; WDR24.
DR InterPro; IPR001841; Znf_RING.
DR PANTHER; PTHR46200; GATOR COMPLEX PROTEIN WDR24; 1.
DR PANTHER; PTHR46200:SF1; GATOR COMPLEX PROTEIN WDR24; 1.
DR Pfam; PF00400; WD40; 2.
DR SMART; SM00320; WD40; 3.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 2.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 3: Inferred from homology;
KW Metal-binding; Reference proteome; Repeat; Vacuole; WD repeat; Zinc;
KW Zinc-finger.
FT CHAIN 1..1386
FT /note="Restriction of telomere capping protein 1"
FT /id="PRO_0000408783"
FT REPEAT 180..227
FT /note="WD 1"
FT REPEAT 234..278
FT /note="WD 2"
FT REPEAT 290..329
FT /note="WD 3"
FT REPEAT 382..428
FT /note="WD 4"
FT REPEAT 1171..1212
FT /note="WD 5"
FT ZN_FING 1338..1381
FT /note="RING-type; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00175"
FT REGION 31..58
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 595..629
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 647..691
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 844..958
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 991..1021
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1090..1157
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 844..930
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 931..945
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1003..1021
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1090..1149
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1386 AA; 154884 MW; E71A249386484993 CRC64;
MPDPNELNAN QSSLSRFAFN IYGALNQAQS LEGNSSASPT PSMNPKQHNK SGTSSSNKEK
LVYNCEREVS CISQFNHSLN GLVKNYEEDP LHHLIIGGKN YLKLLAMNND QTKIVHEVDI
LESSKSIYSS SRTLSSNKLT SVNTIESQHD TIACELATGL ISVYKVQNNG KCKLVRKYSD
HIRCVNSLDF INQSNVANSS SPYQLISGSQ DGTIKLWDLR SASNKPTLTI SSNSHSDPVR
SCQYSPHSTV RNKLTILSVH DSGALCKYDL RSPNGGYQHN INVPERKWNF HTGPALSLNI
HPEKEYVITG GRDQKVCIWN YGDSPTHQNK ISPDYMINTY GPVMKIRWSV YPDNIPSKTD
TSSSQYQQIL ESKRYDDKTS SNERETISTM SSVGKNDPLF NYDFACSFLN EDPTISIYNL
KRKYIPKEVI SSNSNKPFQN FMWAQNISHS RRVWTISKSN QFMSYDLDTA QSDPNIIKPL
DNLTSVSMAW NSGLGDFCFV NQEKDEFESI SQLENDSFRS ESEEYDPEFA LASDGSGLAS
NSGMEDHPTD ERSLKYRISS NSLDNSSIYN NHSKITVASI PIASNASNTP LSYQNPSFSN
SVSPPFEQTT KPSLHRSATH NPMIQPPKPL SSILQNRSSV GIEALMEHGN NNSGSNSASV
SGNHLRPTLN RNHSQSTQGS NVSLSSSIQG YQAPPPVSKR VISVNHPSPY IVPLSLPLPQ
NDEHAFEILS NNYLITVNDG LSLIDVCLYN ANIAAGVNKF RDCQTWRVLA VSLEEDKFSL
INYEENIRSQ FEKAETAITY GSLDTYENNS NTSNSKTQLN QTNDNRSILS ELDNFVGSFN
SNSTSTSNYG GVHSEKDTSN NIELSNANNN GSRKASFSEI KPLSNLNSPS HLKDVLNQSR
SNSNSPVISR SNSMLLKNRK TINTGSTRAE NHESAIDDDD GMGNAKTCEL NENDSQFGMK
NSELKKHSSM SAIDSEAIDN DFPYNIESAK ASPIKIGSQH KHEKNTTSGS MSPQNKDSNH
RGNIINYQRR LSLDPENSRK NSRNAFNYRH TNTWDLDDEN SNIIGNRAQW ATNSSLSSCG
VSSYQPRIGS PNYSDQLHHS YSSTHSSPRP YYNSTTPGSS RRNSHISPVH GFHNKTSYAK
QSPVSQKLMR DEQSRTELKD VQEQIEDLES IEETKVTSVN FGKSELTRAI TGNNTGSPNT
LYKPWKTEYL LKEALEFASL QGDILLCSIL TILFYDYLKV GKDSHVFSKE QSLDWLSLYV
EILHRKQLFS NAMYVVNMAP KELLPDLANL ASTEVNLRFF CCWCQKLLVN EKSKRKALNE
DSFGYWYCDE CSTKQSNCIY CDEPCKGLNI VTSLSCGHRG HFGCLREWFI DQENIVCPGG
CDEQVI
//
