ID RUN3A_PONAB Reviewed; 446 AA.
AC Q5R565;
DT 18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT 21-DEC-2004, sequence version 1.
DT 24-JAN-2024, entry version 60.
DE RecName: Full=RUN domain-containing protein 3A;
GN Name=RUNDC3A;
OS Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pongo.
OX NCBI_TaxID=9601;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain cortex;
RG The German cDNA consortium;
RL Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: May act as an effector of RAP2A in neuronal cells.
CC {ECO:0000250}.
CC -!- SUBUNIT: Interacts with the GTP-bound form of RAP2A. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the RUNDC3 family. {ECO:0000305}.
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DR EMBL; CR861001; CAH93101.1; -; mRNA.
DR RefSeq; NP_001126835.1; NM_001133363.1.
DR AlphaFoldDB; Q5R565; -.
DR SMR; Q5R565; -.
DR STRING; 9601.ENSPPYP00000009369; -.
DR Ensembl; ENSPPYT00000061392.1; ENSPPYP00000041166.1; ENSPPYG00000008334.3.
DR GeneID; 100173842; -.
DR KEGG; pon:100173842; -.
DR CTD; 10900; -.
DR eggNOG; KOG4381; Eukaryota.
DR GeneTree; ENSGT00940000158922; -.
DR InParanoid; Q5R565; -.
DR OrthoDB; 5394269at2759; -.
DR Proteomes; UP000001595; Chromosome 17.
DR CDD; cd17699; RUN_RUNDC3A; 1.
DR Gene3D; 1.20.58.900; -; 1.
DR InterPro; IPR004012; Run_dom.
DR InterPro; IPR037213; Run_dom_sf.
DR InterPro; IPR047338; RUN_RUNDC3A.
DR InterPro; IPR047340; RUNDC3A_B.
DR PANTHER; PTHR46251; RUN DOMAIN-CONTAINING 3 PROTEIN RUNDC3; 1.
DR PANTHER; PTHR46251:SF4; RUN DOMAIN-CONTAINING PROTEIN 3A; 1.
DR Pfam; PF02759; RUN; 1.
DR SMART; SM00593; RUN; 1.
DR SUPFAM; SSF140741; RUN domain-like; 1.
DR PROSITE; PS50826; RUN; 1.
PE 2: Evidence at transcript level;
KW Coiled coil; Phosphoprotein; Reference proteome.
FT CHAIN 1..446
FT /note="RUN domain-containing protein 3A"
FT /id="PRO_0000324157"
FT DOMAIN 52..189
FT /note="RUN"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00178"
FT REGION 1..298
FT /note="Interaction with RAP2A"
FT /evidence="ECO:0000250"
FT REGION 216..239
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 372..404
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 267..322
FT /evidence="ECO:0000255"
FT MOD_RES 215
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:O08576"
FT MOD_RES 232
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:O08576"
FT MOD_RES 416
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:O08576"
FT MOD_RES 419
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:O08576"
SQ SEQUENCE 446 AA; 49777 MW; 9237F36C69E96B93 CRC64;
METSFVQTTM ALGLSSKKAS SRNVAVERKN LITVCRFSVK TLLEKYTAEP IDDSSEEFVN
FAAILEQILS HRFKACAPAG PVSWFSSDGQ RGFWDYIRLA CSKVPNNCVS SIENMENIST
ARAKGRAWIR VALMEKRMSE YITTALRDTR TTRRFYDSGA IMLRDEATIL TGMLIGLSAI
DFSFCLKGEV LDGKTPVVID YTPYLKFTQS YDYLTDEEER HSAESSTSED NSPEHPYLPL
VTDEDSWYSK WHKMEQKFRI VYAQKGYLEE LVRLRESQLK DLEAENRRLQ LQLEEAAAQN
QREKRELEGV ILELQEQLTG LIPSDHAPLA QGSKELTTPL VNQWPSLGTL NGAEGASNSK
LYRRHSFMST EPLSAEASLS SDSQRLGEGT RDEEPWGPIG KDPTPSMLGL CGSLASIPSC
KSLASFKSNE CLVSDSPEGS PALSPS
//
