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Database: UniProt
Entry: RX_DROME
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ID   RX_DROME                Reviewed;         873 AA.
AC   Q9W2Q1; O46035;
DT   02-NOV-2001, integrated into UniProtKB/Swiss-Prot.
DT   02-NOV-2001, sequence version 2.
DT   27-MAR-2024, entry version 166.
DE   RecName: Full=Retinal homeobox protein Rx;
DE            Short=DRx;
DE            Short=DRx1;
GN   Name=Rx; ORFNames=CG10052;
OS   Drosophila melanogaster (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7227;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Canton-S; TISSUE=Embryo;
RX   PubMed=9482887; DOI=10.1073/pnas.95.5.2343;
RA   Eggert T., Hauck B., Hildebrandt N., Gehring W.J., Walldorf U.;
RT   "Isolation of a Drosophila homolog of the vertebrate homeobox gene Rx and
RT   its possible role in brain and eye development.";
RL   Proc. Natl. Acad. Sci. U.S.A. 95:2343-2348(1998).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley;
RX   PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA   Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA   Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA   George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA   Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA   Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA   Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA   An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA   Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA   Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA   Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA   Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA   Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA   Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA   Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA   Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA   Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA   Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA   Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA   Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA   Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA   Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA   McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA   Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA   Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA   Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA   Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA   Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA   Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA   Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA   Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA   Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA   Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA   Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA   Venter J.C.;
RT   "The genome sequence of Drosophila melanogaster.";
RL   Science 287:2185-2195(2000).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=Berkeley;
RX   PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA   Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA   Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA   Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA   Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA   Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA   Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT   "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT   review.";
RL   Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Berkeley; TISSUE=Embryo;
RX   PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA   Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA   Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA   Celniker S.E.;
RT   "A Drosophila full-length cDNA resource.";
RL   Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
RN   [5]
RP   PARTIAL NUCLEOTIDE SEQUENCE.
RX   PubMed=9177348; DOI=10.1038/42475;
RA   Mathers P.H., Grinberg A., Mahon K.A., Jamrich M.;
RT   "The Rx homeobox gene is essential for vertebrate eye development.";
RL   Nature 387:603-607(1997).
CC   -!- FUNCTION: Appears to function in brain development.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108,
CC       ECO:0000255|PROSITE-ProRule:PRU00138}.
CC   -!- DEVELOPMENTAL STAGE: Expressed in the procephalic region and in the
CC       clypeolabrum from stage 8 on and later in the brain and the central
CC       nervous system.
CC   -!- SIMILARITY: Belongs to the paired homeobox family. Bicoid subfamily.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAA11241.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AJ223300; CAA11241.1; ALT_INIT; mRNA.
DR   EMBL; AE013599; AAF46639.3; -; Genomic_DNA.
DR   EMBL; AY118390; AAM48419.1; -; mRNA.
DR   RefSeq; NP_726006.3; NM_166413.3.
DR   AlphaFoldDB; Q9W2Q1; -.
DR   BioGRID; 63010; 10.
DR   IntAct; Q9W2Q1; 7.
DR   STRING; 7227.FBpp0309625; -.
DR   PaxDb; 7227-FBpp0071447; -.
DR   DNASU; 37367; -.
DR   EnsemblMetazoa; FBtr0342783; FBpp0309625; FBgn0020617.
DR   GeneID; 37367; -.
DR   KEGG; dme:Dmel_CG10052; -.
DR   AGR; FB:FBgn0020617; -.
DR   CTD; 37367; -.
DR   FlyBase; FBgn0020617; Rx.
DR   VEuPathDB; VectorBase:FBgn0020617; -.
DR   eggNOG; KOG0490; Eukaryota.
DR   HOGENOM; CLU_320970_0_0_1; -.
DR   InParanoid; Q9W2Q1; -.
DR   OrthoDB; 3042435at2759; -.
DR   PhylomeDB; Q9W2Q1; -.
DR   BioGRID-ORCS; 37367; 0 hits in 3 CRISPR screens.
DR   ChiTaRS; pre-mod(mdg4)-X; fly.
DR   GenomeRNAi; 37367; -.
DR   PRO; PR:Q9W2Q1; -.
DR   Proteomes; UP000000803; Chromosome 2R.
DR   Bgee; FBgn0020617; Expressed in embryonic procephalic segment and 25 other cell types or tissues.
DR   Genevisible; Q9W2Q1; DM.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   CDD; cd00086; homeodomain; 1.
DR   Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR003654; OAR_dom.
DR   PANTHER; PTHR24329:SF543; FI01017P-RELATED; 1.
DR   PANTHER; PTHR24329; HOMEOBOX PROTEIN ARISTALESS; 1.
DR   Pfam; PF00046; Homeodomain; 1.
DR   Pfam; PF03826; OAR; 1.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; Homeodomain-like; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
DR   PROSITE; PS50803; OAR; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..873
FT                   /note="Retinal homeobox protein Rx"
FT                   /id="PRO_0000049288"
FT   DNA_BIND        528..587
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          127..157
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          183..240
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          278..339
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          374..528
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          662..810
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          822..850
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           116..123
FT                   /note="Octapeptide motif"
FT   MOTIF           849..862
FT                   /note="OAR"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00138"
FT   MOTIF           855..859
FT                   /note="Nuclear localization signal"
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        130..144
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        294..322
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        434..477
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        484..509
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        510..527
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        676..696
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        737..810
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        4
FT                   /note="S -> P (in Ref. 1; CAA11241)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        136
FT                   /note="R -> W (in Ref. 1; CAA11241)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        384
FT                   /note="S -> T (in Ref. 1; CAA11241)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        645..672
FT                   /note="PLSLAPGNLTMSSLAAMGHHHAHNGPPP -> QPGARKSDHEQSGGHGPPPC
FT                   PQWAAA (in Ref. 1)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        768
FT                   /note="G -> L (in Ref. 1; CAA11241)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   873 AA;  92897 MW;  87B56AD4693F6710 CRC64;
     MSGSGGVANS SSTAAANNTA ATFQHIFEQL VQQGGGNHKL PPKQLEQLRH LLGNVRDAKN
     LQMIVEKFKN LEQFHEHYAA HLANNNTVIS TEDSNDLVKD NARKYGSGGQ TLTPRHTIDA
     ILGLKNRNGA ANGSGRNPET VSDGSVDPSL GDDDATDLRC GMTLTQLRSM DNHMASMLQQ
     HAKNGGALPY GPPTPPGGQQ PQVPNATPLH HGQQMGGQAG HATHAGHGHP THHGHAPFGY
     HNAFGFGQGG HGYGHPEEAA GNYLNSMHQM VEANQLQTGA NGANPPPAPL PPSSFGSHQQ
     HLAALAAQAQ EQQNQHSKYA KSSPTGAGPP PPPGAYFMES QTAPVAPSQI NYDERSMSSA
     SDLEEDDDDA AKLQLDVTSP PTPSPRGQLA AKRKSAGVFC DDNEPKLANG QLPGGNYGIR
     PRSMEEVHHQ QQSHHHQQQQ QQQQQQQQLQ QQQGFQHDFR NSGNGNPNGN SNSGDHGERL
     NADSDSLVNG SCASSEDLNQ TNSSEQGEKI TSGSDDEGQD DNCAKKKHRR NRTTFTTYQL
     HELERAFEKS HYPDVYSREE LAMKVNLPEV RVQVWFQNRR AKWRRQEKSE SLRLGLTHFT
     QLPHRLGCGA SGLPVDPWLS PPLLSALPGF LSHPQTVYPS YLTPPLSLAP GNLTMSSLAA
     MGHHHAHNGP PPPHVGHGGH GQPQPPPPPP PHGVPHPHGS HHVVPLSHLS PHLSRMSPHA
     TSLGSPHHGV TPLGTPLHSS LPPSSTATTV AVSSSQSSSS SASLECSGPD VCMSPQNLSI
     GNADSNGDGR DLSSDLDAGS TSSNPGSSLD KCAASANIEL LDVGRDSPPP PPTPTGKGSS
     TPPTDMRSNS IATLRIKAKE HLDNLNKGMV SIV
//
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