ID S0DJE3_GIBF5 Unreviewed; 1668 AA.
AC S0DJE3;
DT 18-SEP-2013, integrated into UniProtKB/TrEMBL.
DT 18-SEP-2013, sequence version 1.
DT 27-MAR-2024, entry version 53.
DE RecName: Full=DNA helicase {ECO:0000256|ARBA:ARBA00012551};
DE EC=3.6.4.12 {ECO:0000256|ARBA:ARBA00012551};
GN ORFNames=FFUJ_01067 {ECO:0000313|EMBL:CCT62386.1};
OS Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831) (Bakanae
OS and foot rot disease fungus) (Fusarium fujikuroi).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Nectriaceae; Fusarium;
OC Fusarium fujikuroi species complex.
OX NCBI_TaxID=1279085 {ECO:0000313|EMBL:CCT62386.1, ECO:0000313|Proteomes:UP000016800};
RN [1] {ECO:0000313|Proteomes:UP000016800}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 195.34 / IMI 58289 / NRRL A-6831
RC {ECO:0000313|Proteomes:UP000016800};
RX PubMed=23825955; DOI=10.1371/journal.ppat.1003475;
RA Wiemann P., Sieber C.M., von Bargen K.W., Studt L., Niehaus E.M.,
RA Espino J.J., Huss K., Michielse C.B., Albermann S., Wagner D.,
RA Bergner S.V., Connolly L.R., Fischer A., Reuter G., Kleigrewe K., Bald T.,
RA Wingfield B.D., Ophir R., Freeman S., Hippler M., Smith K.M., Brown D.W.,
RA Proctor R.H., Munsterkotter M., Freitag M., Humpf H.U., Guldener U.,
RA Tudzynski B.;
RT "Deciphering the cryptic genome: genome-wide analyses of the rice pathogen
RT Fusarium fujikuroi reveal complex regulation of secondary metabolism and
RT novel metabolites.";
RL PLoS Pathog. 9:E1003475-E1003475(2013).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC Evidence={ECO:0000256|ARBA:ARBA00001665};
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|ARBA:ARBA00001947};
CC -!- SIMILARITY: Belongs to the helicase family. RecQ subfamily.
CC {ECO:0000256|ARBA:ARBA00005446}.
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DR EMBL; HF679023; CCT62386.1; -; Genomic_DNA.
DR STRING; 1279085.S0DJE3; -.
DR EnsemblFungi; CCT62386; CCT62386; FFUJ_01067.
DR VEuPathDB; FungiDB:FFUJ_01067; -.
DR HOGENOM; CLU_001103_16_1_1; -.
DR OrthoDB; 5474026at2759; -.
DR Proteomes; UP000016800; Chromosome 1.
DR GO; GO:0043138; F:3'-5' DNA helicase activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0006310; P:DNA recombination; IEA:InterPro.
DR GO; GO:0006281; P:DNA repair; IEA:InterPro.
DR GO; GO:0006260; P:DNA replication; IEA:InterPro.
DR CDD; cd17920; DEXHc_RecQ; 1.
DR CDD; cd18794; SF2_C_RecQ; 1.
DR Gene3D; 1.10.150.80; HRDC domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR002464; DNA/RNA_helicase_DEAH_CS.
DR InterPro; IPR004589; DNA_helicase_ATP-dep_RecQ.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR010997; HRDC-like_sf.
DR InterPro; IPR002121; HRDC_dom.
DR InterPro; IPR044876; HRDC_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR032284; RecQ_Zn-bd.
DR InterPro; IPR018982; RQC_domain.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR NCBIfam; TIGR00614; recQ_fam; 1.
DR PANTHER; PTHR13710:SF105; BLOOM SYNDROME PROTEIN; 1.
DR PANTHER; PTHR13710; DNA HELICASE RECQ FAMILY MEMBER; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF16124; RecQ_Zn_bind; 1.
DR Pfam; PF09382; RQC; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SMART; SM00956; RQC; 1.
DR SUPFAM; SSF47819; HRDC-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS00690; DEAH_ATP_HELICASE; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
DR PROSITE; PS50967; HRDC; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000016800}.
FT DOMAIN 836..1017
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 1041..1189
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT DOMAIN 1452..1534
FT /note="HRDC"
FT /evidence="ECO:0000259|PROSITE:PS50967"
FT REGION 31..88
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 106..171
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 206..422
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 649..685
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 720..743
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1341..1442
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1557..1578
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1590..1668
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 31..53
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 67..88
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 108..139
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 206..233
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 255..270
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 298..331
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 357..376
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 391..422
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1366..1383
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1590..1609
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1625..1652
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1668 AA; 184095 MW; 0C1F049C5F7FE002 CRC64;
MTRNNLAEHL SWLLNDQACS RPVTPSFPVC SDSSQITLPQ SQHTSSQTRP NKRTTTSDHP
EVATRGGSDA SGTSNGRAGL GPTSRQTDQV IFDDEEDVMG RLALSSKTKK PSLVSKPQQC
PAPLTVTPDI STQRDVTLKR SNEPPPKKIQ APVSVSARQP TSSPDFPKLK AGGIDYMDLT
DDTFASSDSL SFGSDVKLWR EDYATRPEPE PAVSSGRKRK SNEISKEEFS DFGDLPDVYE
LLGTEPPPPS PTRSARRKNG LSSARTRQIR DIPSISEEDH VMLSPSARVR SQFVGEERTA
PLNESNQDLE GSSNLLKAPA SSGNTKSPLR APSLPPHTIP TGDELVIPDS DDEFLTPPSH
NDSVTILKSS AVGSDSVESP DPKPPISAVK IDLHTTSQRQ ISSGSTITGE PTSTTNSSQS
NRLITGDAPH ESCGEVFFLS SQEPVLLKQL ASDSNALANW AEFLDRLIQE NGKKFSQAIN
ERWSKPQRAE VKAEKERLKR QRSAIAELAG PVEEYRILGE KRESLAQQIA QAYEESLDTD
EDEVRLDDLT DEIQEVEDGL LKSIRDARLD VGGFLATTNT LHPGPAPTPV VVLGTQPVFQ
NNVNMSMASR DAIPASETGT QVVHQTQLPK TNAWNPPASR IEASQGLSVL SQEDTDPSAL
FPRDPTRVSG APYQQGRILK SRPVSPIPVD AEFDISDEEP SDSEDIQSRI QARPPNIFAH
LSSSSRRTPQ ATHHRAGDEF SDFSDDEEML AFAQDYEIRQ SLAPESQDQR KIFSETSGNA
SAAAKSRAVS NKSLPLMATE AIPAQLMKYS WSSEVQRMLK DRFRMKGFRC NQLEAINATL
GGQDAFVLMP TGGGKSLCYQ LPAVVKTGKT RGVTIVVSPL LSLMQDQVDH MKALGIQAVA
FNGECSAEYK RQVMSAFNEK SPEHFLELLY VTPEMVSKNV NFNNGLETLH RKGKFARLVI
DEAHCVSQWG HDFRPDYKIL GQVRQKYPGV PVMALTATAT KNVIVDIRHN LGMDNCQIFS
QSFNRPNLYY EVRPKTTNEK VMDAISSLIH SRYANQSGIV YTISRKNAEK VAESLSNKGI
TARFYHAGCD PQEKVEVQNS WQRGQVKVVV ATIAFGMGID KPDVRFVIHH GLPKSLEGYY
QETGRAGRDG NPSDCILFYG KADIRVLKKL IADGDGSHDQ KERQMSMLNR VTAFCDNKSD
CRRTEILRYF GEDFSATQCR KSCDNCKAGL TFEQQDFSEY AVAAIKVVQA QNRITAVQCS
DILLGKKYPT NEAELSDEWH GMAKGLKKHE LIRVIDKLSA EKAFNEDNQV GRHGMAIQYL
RLGPTYRSFL SGQRRLMLSI QVPEPGAAKK TPKSRSKKGS KASAEEEASN MPSTYVSSPV
GRQKKKSRTT ETNRGNTGQT SYSWEDAGFV MDDDDDYDDA FDNLPQHRPA KPPSRTSGPP
ILVDTDMGSL DEIHRDMVES FVREAKQTEE KIRNQKSLRR PLFTDKDFRL MAIHWTTSPE
KMRRIPGIDP DKVNDYGPRI LRILQKHYNH YREAMDPRSG GRDQDVVDLI SSEVEMDDEA
LEDEDGEDSH YFNGSSRPDV QAFHSRLQTL GSTQTQAKPR ASSKSSGGTK KYAGGKRYPS
KKPTSGVTKR RSTGASSSRK ASGSSTAGRT SGAAPKTLKK SGIGLMPM
//
