ID S0E1S1_GIBF5 Unreviewed; 502 AA.
AC S0E1S1;
DT 18-SEP-2013, integrated into UniProtKB/TrEMBL.
DT 18-SEP-2013, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE RecName: Full=sphingosine kinase {ECO:0000256|ARBA:ARBA00044037};
DE EC=2.7.1.91 {ECO:0000256|ARBA:ARBA00044037};
GN ORFNames=FFUJ_07626 {ECO:0000313|EMBL:CCT68809.1};
OS Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831) (Bakanae
OS and foot rot disease fungus) (Fusarium fujikuroi).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Nectriaceae; Fusarium;
OC Fusarium fujikuroi species complex.
OX NCBI_TaxID=1279085 {ECO:0000313|EMBL:CCT68809.1, ECO:0000313|Proteomes:UP000016800};
RN [1] {ECO:0000313|Proteomes:UP000016800}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 195.34 / IMI 58289 / NRRL A-6831
RC {ECO:0000313|Proteomes:UP000016800};
RX PubMed=23825955; DOI=10.1371/journal.ppat.1003475;
RA Wiemann P., Sieber C.M., von Bargen K.W., Studt L., Niehaus E.M.,
RA Espino J.J., Huss K., Michielse C.B., Albermann S., Wagner D.,
RA Bergner S.V., Connolly L.R., Fischer A., Reuter G., Kleigrewe K., Bald T.,
RA Wingfield B.D., Ophir R., Freeman S., Hippler M., Smith K.M., Brown D.W.,
RA Proctor R.H., Munsterkotter M., Freitag M., Humpf H.U., Guldener U.,
RA Tudzynski B.;
RT "Deciphering the cryptic genome: genome-wide analyses of the rice pathogen
RT Fusarium fujikuroi reveal complex regulation of secondary metabolism and
RT novel metabolites.";
RL PLoS Pathog. 9:E1003475-E1003475(2013).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a sphingoid base + ATP = a sphingoid 1-phosphate + ADP + H(+);
CC Xref=Rhea:RHEA:51496, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:76941, ChEBI:CHEBI:84410, ChEBI:CHEBI:456216;
CC EC=2.7.1.91; Evidence={ECO:0000256|ARBA:ARBA00043822};
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DR EMBL; HF679027; CCT68809.1; -; Genomic_DNA.
DR AlphaFoldDB; S0E1S1; -.
DR STRING; 1279085.S0E1S1; -.
DR EnsemblFungi; CCT68809; CCT68809; FFUJ_07626.
DR VEuPathDB; FungiDB:FFUJ_07626; -.
DR HOGENOM; CLU_013399_0_1_1; -.
DR OrthoDB; 374620at2759; -.
DR Proteomes; UP000016800; Chromosome 5.
DR GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR Gene3D; 2.60.200.40; -; 1.
DR InterPro; IPR017438; ATP-NAD_kinase_N.
DR InterPro; IPR001206; Diacylglycerol_kinase_cat_dom.
DR InterPro; IPR016064; NAD/diacylglycerol_kinase_sf.
DR PANTHER; PTHR12358:SF31; LD11247P-RELATED; 1.
DR PANTHER; PTHR12358; SPHINGOSINE KINASE; 1.
DR Pfam; PF00781; DAGK_cat; 1.
DR SMART; SM00046; DAGKc; 1.
DR SUPFAM; SSF111331; NAD kinase/diacylglycerol kinase-like; 1.
DR PROSITE; PS50146; DAGK; 1.
PE 4: Predicted;
KW Kinase {ECO:0000313|EMBL:CCT68809.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000016800};
KW Transferase {ECO:0000313|EMBL:CCT68809.1}.
FT DOMAIN 117..256
FT /note="DAGKc"
FT /evidence="ECO:0000259|PROSITE:PS50146"
SQ SEQUENCE 502 AA; 54966 MW; DA0D8F9FEFD80B37 CRC64;
MDEGIGMLLL LEDKKKLTIG IDELELNDPA ANKSTRSSCA PFSGKSAPNN SIPFYNVLWA
ELSNDQIIID YAHHASKTLI KPKKWVFTLA KDDESTSGTP AEIFVKTLMT RAYGDAQSQK
RAYVLINPNS GPGGAIKQWE TEVKPLFQAA KMQIDPVILK HGGEAVELAQ NADLSRYDTI
MACSGDGTPH EIFNGLAKRP DAARALSTMP VSHIPCGSGN AFSCNLYGSH RPSFAALAII
KGVVTPMDLV SVTSGHNRII SFLSQTLGLI AECDLGTEHM RWMGSARFEV GVVQRMFKKK
CYPFDLAVKV EIEDKSDVKA HYKHHASSTS LNHLAKKLDA DPVAEDAGLP PLKYGTIQDD
LPEGWELIPY DKVGTFYAGN MAYMSPDAPF FAASLISDGL MDLVTIDGDL PFFTAIKVLL
DVEAEKLFDN PHVTYKKISA YRIIPRDQED GYISIDGEKC PFGPFQAEIH QGLGRVISKS
GKYEAAGPKN WDKVTLADRI HG
//
