ID S0EET6_GIBF5 Unreviewed; 549 AA.
AC S0EET6;
DT 18-SEP-2013, integrated into UniProtKB/TrEMBL.
DT 18-SEP-2013, sequence version 1.
DT 24-JAN-2024, entry version 35.
DE RecName: Full=NEDD8-activating enzyme E1 regulatory subunit {ECO:0000256|PIRNR:PIRNR039099};
GN ORFNames=FFUJ_09724 {ECO:0000313|EMBL:CCT73476.1};
OS Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831) (Bakanae
OS and foot rot disease fungus) (Fusarium fujikuroi).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Nectriaceae; Fusarium;
OC Fusarium fujikuroi species complex.
OX NCBI_TaxID=1279085 {ECO:0000313|EMBL:CCT73476.1, ECO:0000313|Proteomes:UP000016800};
RN [1] {ECO:0000313|Proteomes:UP000016800}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 195.34 / IMI 58289 / NRRL A-6831
RC {ECO:0000313|Proteomes:UP000016800};
RX PubMed=23825955; DOI=10.1371/journal.ppat.1003475;
RA Wiemann P., Sieber C.M., von Bargen K.W., Studt L., Niehaus E.M.,
RA Espino J.J., Huss K., Michielse C.B., Albermann S., Wagner D.,
RA Bergner S.V., Connolly L.R., Fischer A., Reuter G., Kleigrewe K., Bald T.,
RA Wingfield B.D., Ophir R., Freeman S., Hippler M., Smith K.M., Brown D.W.,
RA Proctor R.H., Munsterkotter M., Freitag M., Humpf H.U., Guldener U.,
RA Tudzynski B.;
RT "Deciphering the cryptic genome: genome-wide analyses of the rice pathogen
RT Fusarium fujikuroi reveal complex regulation of secondary metabolism and
RT novel metabolites.";
RL PLoS Pathog. 9:E1003475-E1003475(2013).
CC -!- FUNCTION: Regulatory subunit of the dimeric UBA3-ULA1 E1 enzyme.
CC {ECO:0000256|PIRNR:PIRNR039099}.
CC -!- PATHWAY: Protein modification; protein neddylation.
CC {ECO:0000256|ARBA:ARBA00005032, ECO:0000256|PIRNR:PIRNR039099}.
CC -!- SIMILARITY: Belongs to the ubiquitin-activating E1 family. ULA1
CC subfamily. {ECO:0000256|ARBA:ARBA00006868,
CC ECO:0000256|PIRNR:PIRNR039099}.
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DR EMBL; HF679031; CCT73476.1; -; Genomic_DNA.
DR AlphaFoldDB; S0EET6; -.
DR STRING; 1279085.S0EET6; -.
DR EnsemblFungi; CCT73476; CCT73476; FFUJ_09724.
DR VEuPathDB; FungiDB:FFUJ_09724; -.
DR HOGENOM; CLU_019618_1_0_1; -.
DR OrthoDB; 5488891at2759; -.
DR UniPathway; UPA00885; -.
DR Proteomes; UP000016800; Chromosome 9.
DR GO; GO:0019781; F:NEDD8 activating enzyme activity; IEA:UniProtKB-UniRule.
DR GO; GO:0045116; P:protein neddylation; IEA:UniProtKB-UniRule.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR Gene3D; 3.40.50.12550; Ubiquitin-activating enzyme E1, inactive adenylation domain, subdomain 2; 1.
DR InterPro; IPR030667; APP-BP1.
DR InterPro; IPR045886; ThiF/MoeB/HesA.
DR InterPro; IPR000594; ThiF_NAD_FAD-bd.
DR InterPro; IPR035985; Ubiquitin-activating_enz.
DR PANTHER; PTHR10953:SF29; NEDD8-ACTIVATING ENZYME E1 REGULATORY SUBUNIT; 1.
DR PANTHER; PTHR10953; UBIQUITIN-ACTIVATING ENZYME E1; 1.
DR Pfam; PF00899; ThiF; 1.
DR PIRSF; PIRSF039099; APP-BP1; 1.
DR SUPFAM; SSF69572; Activating enzymes of the ubiquitin-like proteins; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000016800};
KW Ubl conjugation pathway {ECO:0000256|PIRNR:PIRNR039099}.
FT DOMAIN 22..540
FT /note="THIF-type NAD/FAD binding fold"
FT /evidence="ECO:0000259|Pfam:PF00899"
SQ SEQUENCE 549 AA; 60994 MW; 6EB1F71D41163640 CRC64;
MADVMVQTPP VLQGPSEKER KYDRQLRLWA ASGQAALESA NILLVNSGAG TVGVETLKNL
VLPGIGRFTI ADQNVVTHQD LGVNFFVDDS WLGKSRAEAC TDFLLELNPE VQGEWYPKPQ
DESFHLDHFL SSSPTFTMIL YALPLPQDQV QLIRGYSHQH KIPTIAVHSV GYYSYFKTTL
PGTFPIVDTH PDETATTDLR LLAPWPELLE FSQSMTENID NLDSHEHGHL PMVVILFHYL
EQWKQAHGGA YPTSYVDKTA FRKTVSEAMR TDNPEGGEEN FEEAIAAVMK HVVKPSLPSS
LQQVFDHVHQ DPVRISAIIV NFIANLCQEE TTSSFWVITE AVKRFYDQHG RLPVPGGLPD
MKAQSNVYIK LQNIYKERAR QDVGQVLETA RSLPGGQDVD PEQVELFCKN ASFIKLINAS
GDKSISLDKL VEQELANDEI SAFAGPEMPL SLVPLYLALL ATSNTKTASA DDIMDFVGKA
APKATENERY KKTAQEVERA AGGELHNISA LTGGMVAQEM IKIITKQYVP IDNTCIFDGI
DSRCQVLRL
//
