ID   S0IZX0_9FIRM            Unreviewed;       583 AA.
AC   S0IZX0;
DT   18-SEP-2013, integrated into UniProtKB/TrEMBL.
DT   18-SEP-2013, sequence version 1.
DT   24-JAN-2024, entry version 28.
DE   SubName: Full=Stage V sporulation protein D (Sporulation-specific penicillin-binding protein) {ECO:0000313|EMBL:EOT25502.1};
GN   ORFNames=C805_02131 {ECO:0000313|EMBL:EOT25502.1};
OS   Eubacterium sp. 14-2.
OC   Bacteria; Bacillota; Clostridia; Eubacteriales; Eubacteriaceae;
OC   Eubacterium.
OX   NCBI_TaxID=1235790 {ECO:0000313|EMBL:EOT25502.1, ECO:0000313|Proteomes:UP000014176};
RN   [1] {ECO:0000313|EMBL:EOT25502.1, ECO:0000313|Proteomes:UP000014176}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=14-2 {ECO:0000313|EMBL:EOT25502.1,
RC   ECO:0000313|Proteomes:UP000014176};
RG   The Broad Institute Genomics Platform;
RG   The Broad Institute Genome Sequencing Center for Infectious Disease;
RA   Earl A., Xavier R., Elson C., Duck W., Walker B., Young S., Zeng Q.,
RA   Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA   Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA   Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA   Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA   Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA   Birren B.;
RT   "The Genome Sequence of Eubacterium bacterium 14-2.";
RL   Submitted (APR-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the transpeptidase family.
CC       {ECO:0000256|ARBA:ARBA00007171}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EOT25502.1}.
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DR   EMBL; ASSS01000009; EOT25502.1; -; Genomic_DNA.
DR   RefSeq; WP_016215161.1; NZ_KE159567.1.
DR   AlphaFoldDB; S0IZX0; -.
DR   STRING; 1235790.C805_02131; -.
DR   PATRIC; fig|1235790.3.peg.2294; -.
DR   eggNOG; COG0768; Bacteria.
DR   HOGENOM; CLU_009289_6_0_9; -.
DR   OrthoDB; 9804124at2; -.
DR   Proteomes; UP000014176; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0008658; F:penicillin binding; IEA:InterPro.
DR   Gene3D; 3.30.450.330; -; 1.
DR   Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR   Gene3D; 3.90.1310.10; Penicillin-binding protein 2a (Domain 2); 1.
DR   InterPro; IPR012338; Beta-lactam/transpept-like.
DR   InterPro; IPR005311; PBP_dimer.
DR   InterPro; IPR036138; PBP_dimer_sf.
DR   InterPro; IPR001460; PCN-bd_Tpept.
DR   PANTHER; PTHR30627; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE; 1.
DR   PANTHER; PTHR30627:SF1; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE FTSI; 1.
DR   Pfam; PF03717; PBP_dimer; 1.
DR   Pfam; PF00905; Transpeptidase; 1.
DR   SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
DR   SUPFAM; SSF56519; Penicillin binding protein dimerisation domain; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000014176};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        12..35
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          55..199
FT                   /note="Penicillin-binding protein dimerisation"
FT                   /evidence="ECO:0000259|Pfam:PF03717"
FT   DOMAIN          244..560
FT                   /note="Penicillin-binding protein transpeptidase"
FT                   /evidence="ECO:0000259|Pfam:PF00905"
SQ   SEQUENCE   583 AA;  64737 MW;  3F10B692E0011091 CRC64;
     MFRNKTFNRK KLLVVFTIVM LILSILVGRL VYLMIFCSEY YGKKAEDLHE RERDIKAARG
     KIIDATGTVL ATNRTVCTIS VIHSQIKDPE EVIRVLTKEL ELEEAAVRKR VEKVSSIERV
     KSNVDKEVGD RIRNYGLAGV KVDEDYKRYY PYGTLASKVL GFTGGDNQGI IGLEVKYEEY
     LKGKSGKILT LTDARGIEME NAGERRQEPV DGYNLHVSLD YNIQMYCEQA AKKVMEAKSA
     DGVSVIVMKP DNGEILAMVN VPEFDLNDPF TLPEMSEEAE KNKQDLLNQM WRNPCINDTY
     EPGSVFKIIT TASAFEEGVV SLSDQFFCPG YKMVEDRRIH CHKRTGHGSE DFTQGIMNSC
     NPVFIELGLR LGVDNIYKYF EQFGLLSRTG IDLPGEAATI MHNKNNVGPV ELATVSFGQS
     FQVTPIQLAT TVSSLINGGK RITPHFGVAV KDDQGELIET LQYDVQEGIV SSETSQVLRT
     VLEKVVAEGS GKRAFIEGFS IGGKTATSQT LPRSANKYIS SFLGFAPADN PQVLALVVIN
     NPQGIYYGGT IAAPVVKEIF SNILPYLGIE KEVDPAKKEQ ALE
//