ID S1PZP7_ECOLX Unreviewed; 471 AA.
AC S1PZP7;
DT 18-SEP-2013, integrated into UniProtKB/TrEMBL.
DT 18-SEP-2013, sequence version 1.
DT 24-JAN-2024, entry version 37.
DE RecName: Full=Flagellar hook-associated protein 2 {ECO:0000256|ARBA:ARBA00016246, ECO:0000256|RuleBase:RU362066};
DE Short=HAP2 {ECO:0000256|RuleBase:RU362066};
DE AltName: Full=Flagellar cap protein {ECO:0000256|RuleBase:RU362066};
GN ORFNames=A13A_01960 {ECO:0000313|EMBL:EOW97626.1};
OS Escherichia coli KTE182.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=1181728 {ECO:0000313|EMBL:EOW97626.1, ECO:0000313|Proteomes:UP000014179};
RN [1] {ECO:0000313|EMBL:EOW97626.1, ECO:0000313|Proteomes:UP000014179}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KTE182 {ECO:0000313|EMBL:EOW97626.1,
RC ECO:0000313|Proteomes:UP000014179};
RG The Broad Institute Genome Sequencing Platform;
RG The Broad Institute Genome Sequencing Center for Infectious Disease;
RA Feldgarden M., Nielsen K.L., Frimodt-Moller N., Andersen P.S., Walker B.,
RA Young S.K., Zeng Q., Gargeya S., Fitzgerald M., Haas B., Abouelleil A.,
RA Alvarado L., Arachchi H.M., Berlin A.M., Chapman S.B., Dewar J.,
RA Goldberg J., Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A.,
RA Larimer J., McCowan C., Murphy C., Neiman D., Pearson M., Priest M.,
RA Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Escherichia coli KTE182.";
RL Submitted (JAN-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Required for morphogenesis and for the elongation of the
CC flagellar filament by facilitating polymerization of the flagellin
CC monomers at the tip of growing filament. Forms a capping structure,
CC which prevents flagellin subunits (transported through the central
CC channel of the flagellum) from leaking out without polymerization at
CC the distal end. {ECO:0000256|RuleBase:RU362066}.
CC -!- FUNCTION: Required for the morphogenesis and for the elongation of the
CC flagellar filament by facilitating polymerization of the flagellin
CC monomers at the tip of growing filament. Forms a capping structure,
CC which prevents flagellin subunits (transported through the central
CC channel of the flagellum) from leaking out without polymerization at
CC the distal end. {ECO:0000256|ARBA:ARBA00025175}.
CC -!- SUBUNIT: Homopentamer. {ECO:0000256|ARBA:ARBA00011255,
CC ECO:0000256|RuleBase:RU362066}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|RuleBase:RU362066}.
CC Bacterial flagellum {ECO:0000256|RuleBase:RU362066}.
CC -!- SIMILARITY: Belongs to the FliD family. {ECO:0000256|ARBA:ARBA00009764,
CC ECO:0000256|RuleBase:RU362066}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EOW97626.1}.
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DR EMBL; ASUG01000035; EOW97626.1; -; Genomic_DNA.
DR RefSeq; WP_000146828.1; NZ_KE136862.1.
DR AlphaFoldDB; S1PZP7; -.
DR PATRIC; fig|1181728.3.peg.2017; -.
DR HOGENOM; CLU_015182_8_1_6; -.
DR Proteomes; UP000014179; Unassembled WGS sequence.
DR GO; GO:0009421; C:bacterial-type flagellum filament cap; IEA:InterPro.
DR GO; GO:0009424; C:bacterial-type flagellum hook; IEA:UniProtKB-UniRule.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0007155; P:cell adhesion; IEA:InterPro.
DR InterPro; IPR010810; Flagellin_hook_IN_motif.
DR InterPro; IPR040026; FliD.
DR InterPro; IPR010809; FliD_C.
DR InterPro; IPR003481; FliD_N.
DR PANTHER; PTHR30288; FLAGELLAR CAP/ASSEMBLY PROTEIN FLID; 1.
DR PANTHER; PTHR30288:SF0; FLAGELLAR HOOK-ASSOCIATED PROTEIN 2; 1.
DR Pfam; PF07196; Flagellin_IN; 1.
DR Pfam; PF07195; FliD_C; 1.
DR Pfam; PF02465; FliD_N; 1.
PE 3: Inferred from homology;
KW Bacterial flagellum {ECO:0000256|ARBA:ARBA00023143,
KW ECO:0000256|RuleBase:RU362066};
KW Cell projection {ECO:0000313|EMBL:EOW97626.1};
KW Cilium {ECO:0000313|EMBL:EOW97626.1};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|RuleBase:RU362066};
KW Flagellum {ECO:0000313|EMBL:EOW97626.1};
KW Secreted {ECO:0000256|RuleBase:RU362066}.
FT DOMAIN 11..106
FT /note="Flagellar hook-associated protein 2 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF02465"
FT DOMAIN 224..454
FT /note="Flagellar hook-associated protein 2 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF07195"
FT COILED 410..437
FT /evidence="ECO:0000256|RuleBase:RU362066"
SQ SEQUENCE 471 AA; 48830 MW; 2890B8AD334C6E64 CRC64;
MASISTLGVG SGLDLSSILD SLEAAEKSTL TPISKQQSSY TAKLSAYGTL KSALESFQTA
NTALNKADLF TATSTTSSSS AFSATTTGSA IAGKYTISVS QLAQAQTLTT KNSQKDSKAA
IATSDSVLTI QQGGGKDPVT IDISAGNSSL SGIRDAINNA KAGVSASIIN VGNGEYRLSI
TANDTGSDNA MKLSVSGDSA LESFMGYNGT PGDSSNGMIE SVTAQNAKLT VNNVEIENSS
NTISDSLEDI TLNLNDVTTG NQTLTISKDT SKAENAVKAW VDAYNTLQDT FSSLTKYTAV
DAGAESQDSS NGALLGDSTL RTIQTQLKTL LANTHSSSNY KTLAQIGITS DASTGKLEIA
TDKLQTALKN DAAGIGEMFI GDGKSTGVTT GISSNLTSWL SSTGIIQAAK DGVSKTLNNL
TDQYNAASER IDTLMTRYKA QFTQLDVLMN SLNSTSSYLT QQFDTSNSNS K
//